JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (10): 46-49.doi: 10.6040/j.issn.1671-7554.0.2015.922

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Correlation among cognitive impairment and high homocysteinemia as well as the number and volume of infarct in patients with lacunar cerebral infarction

DONG Fang1,2, DU Yifeng2   

  1. 1. Department of Neurology, Tengzhou Traditional Chinese Hospital, Tengzhou 277599, Shandong, China;
    2. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2015-09-28 Online:2016-10-10 Published:2016-10-10

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Abstract: Objective To investigate the correlation between the extent of the vascular cognitive impairment(VCI)and the level of homocystein(HCY)in plasma as well as the number and volume of infarct in patients with lacunar cerebral infarction. Methods A total of 196 lacunar infarction patients who were hospitalized in Tengzhou Traditional Chinese Hospital, from Oct. 2011 to Oct. 2013, for the first time and 201 healthy volunteers(control group)were included in this study. Levels of plasma Hcy were detected in all subjects. The number and total volume of lacunar infarct(mm3)were determined by using MRI detection. Patients were divided into normal cognitive group(n=155), mild VCI group 山 东 大 学 学 报 (医 学 版)54卷10期 -董芳,等.腔隙性脑梗死患者认知障碍与高同型半胱氨酸血症、梗死灶数目及体积的相关性 \=-(n=35)and dementia group(n=6), according to the cognitive function score of Minimum Mental State Examination(MMSE). The levels of plasma Hcy were compared between patients and control group. Spearman correlation was used to analyze the correlations among the cognitive function and the levels of plasma Hcy, the number and total volume of lacunar infarction. Results The proportion of subjects with plasma Hcy levels ≥10 μmol/L in patients with lacunar infarction(91.84%)was higher than that in the controls(65.67%). The levels of plasma Hcy in dementia group ［(51.37±8.12 )μmol/L］, mild VCI group ［(28.06±7.56)μmol/L］ and normal cognitive group ［(21.70±6.92)μmol/L］ were significantly higher than that in control group(P<0.01). The differences in total number and volume of lacunar infarcts between dementia group ［number 8.00±1.67; total volume(27.42±9.34)mm3］ and mild VCI group ［number 4.77±0.77; total volume(14.96±6.89)mm3］ as well as normal cognitive group ［number 3.52±0.81; total volume(8.81±3.71)mm3］ were statistically significant(P<0.01). Conclusion There is negative correlation between the cognitive level detected by MMSE and HCY, and also between the number and the total volume of infarction in patients with cerebral lacunar infarction.

Key words: Vascular cognitive impairment(VCI), Lacunar infarction, Homocysteine, Magnetic resonance imaging(MRI)

CLC Number: 

  • R743.3
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