JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (1): 54-57.doi: 10.6040/j.issn.1671-7554.0.2014.513

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Cerebral protection of Xingnaojing injection in patients undergoing cardiopulmonary bypass surgery

HAN Xiao, LIU Kun, SHI Jiahai, GAO Fumin, YOU Qingsheng   

  1. Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China
  • Received:2014-08-06 Revised:2014-11-03 Published:2015-01-10

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Abstract: Objective To explore the effects and possible influence of Xingnaojing injection in cardiopulmonary bypass surgery with brain function. Methods Thirty valve replacement patients were randomly categorized into the experience group and the control group with 15 cases in each group. The experience group was treated with Xingnaojing injection(0.33 mL/kg) in the priming solution, while the control group were treated with 0.9% sodium chloride solution(0.33 mL/kg). To extract the patients' blood in the jugular venous and radial artery in turn before cardiopulmonary bypass(T1), 30 mins after aortic cross-clamping (T2), 30 mins after aortic opening(T3), 2 hours after aortic opening(T4) for the detection of neuron specific enolase(NSE), homocysteine (Hcy) and blood gas. At the same time, cerebral oxygen uptake rate(CEO2) was calculated according to the blood gas in the above mentioned time points of extracorporeal circulation. The incidence of postoperative delirium was compared between the two groups with Confusion Assessment Method for Intensive Care Unit(CAM-ICU). Results In cardiac operation with extracorporeal circulation, the level of NSE in the experience group was significantly lower than that of the control group at the time points of T2、T3、T4(P<0.05). The level of Hcy in the experience group was also significantly lower than that of the control group at the time points of T3、T4(P<0.05). The value of CEO2 in the experience group were significantly higher than that of the control group at the time points of T4(P<0.05). The incidence of postoperative delirium was significantly lower in the experience group(6.7%) compared with the control group(33.3%) (P<0.05). Conclusion Xingnaojing injectioncan effectively regulate NSE and Hcy in cardiopulmonary bypass heart operation. It can alleviate brain injury and promote the early recovery of brain function, thus, effectively reduce the incidence of early postoperative delirium in patients.

Key words: Cardiopulmonary bypass, Homocysteine, Delirium, Xingnaojing injection, Neuron-specific enolase, Cerebral oxygen uptake rate

CLC Number: 

  • R654.1
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