JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (1): 58-62.doi: 10.6040/j.issn.1671-7554.0.2014.551

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Correlation between pituitary MRI and endocrine functions in patients with pituitary stalk interruption syndrome

WANG Fengxue, WANG Qian, LI Guimei, HU Yanyan, WANG Zengmin   

  1. Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2014-08-25 Revised:2014-11-04 Published:2015-01-10

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Abstract: Objective To investigate the correlation between magnetic resonance imaging (MRI) and levels of pituitary-target hormones in patients with pituitary stalk interruption syndrome (PSIS). Methods A total of 64 patients with PSIS were divided into two groups according to the appearance of pituitary stalk: partial PSIS group (group pPSIS) and complete PSIS group (group cPSIS). Meanwhile, 60 healthy children and teenagers were recruited as controls. Pituitary functions were measured and compared between PSIS patients and age-matched controls. Results There was significantly small anterior pituitary in cPSIS group (P<0.01). The incidence of ectopic posterior pituitary was significantly higher in cPSIS group than in pPSIS group (P<0.01). In addition, serum levels of growth hormone (GH), pituitary-thyroid hormones, and pituitary-adrenal hormones were significantly lower in the two PSIS groups than in the controls, and those were lower in cPSIS group than in pPSIS group (P<0.01). The levels of pituitary-gonadal hormones were not significantly different in the two PSIS groups, except for testosterone (T, P<0.05). Conclusion Grades of MRI can predict occurrence and severity of PSIS, which are also correlated with the levels of the pituitary-target hormone deficiencies.

Key words: Magnetic resonance imaging, Pituitary hormone deficiency, Growth hormone deficiency, Complete pituitary stalk interruption syndrome, Partial pituitary stalk interruption syndrome

CLC Number: 

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