JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (1): 58-62.doi: 10.6040/j.issn.1671-7554.0.2014.551

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Correlation between pituitary MRI and endocrine functions in patients with pituitary stalk interruption syndrome

WANG Fengxue, WANG Qian, LI Guimei, HU Yanyan, WANG Zengmin   

  1. Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2014-08-25 Revised:2014-11-04 Published:2015-01-10

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Abstract: Objective To investigate the correlation between magnetic resonance imaging (MRI) and levels of pituitary-target hormones in patients with pituitary stalk interruption syndrome (PSIS). Methods A total of 64 patients with PSIS were divided into two groups according to the appearance of pituitary stalk: partial PSIS group (group pPSIS) and complete PSIS group (group cPSIS). Meanwhile, 60 healthy children and teenagers were recruited as controls. Pituitary functions were measured and compared between PSIS patients and age-matched controls. Results There was significantly small anterior pituitary in cPSIS group (P<0.01). The incidence of ectopic posterior pituitary was significantly higher in cPSIS group than in pPSIS group (P<0.01). In addition, serum levels of growth hormone (GH), pituitary-thyroid hormones, and pituitary-adrenal hormones were significantly lower in the two PSIS groups than in the controls, and those were lower in cPSIS group than in pPSIS group (P<0.01). The levels of pituitary-gonadal hormones were not significantly different in the two PSIS groups, except for testosterone (T, P<0.05). Conclusion Grades of MRI can predict occurrence and severity of PSIS, which are also correlated with the levels of the pituitary-target hormone deficiencies.

Key words: Magnetic resonance imaging, Pituitary hormone deficiency, Growth hormone deficiency, Complete pituitary stalk interruption syndrome, Partial pituitary stalk interruption syndrome

CLC Number: 

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[1] Acharya SV, Gopal RA, Lila A, et al. Phenotype and radiological correlation in patients with growth hormone deficiency[J]. Indian J Pediatr, 2011, 78(1):49-54.
[2] Reynaud R, Albarel F, Saveanu A, et al. Pitui tary stalk interruption syndrome in 83 patients: Novel HESX1 mutation and severe hormonal prognosis in malformative forms[J]. Eur J Endocrinol, 2011, 164(4):457-465.
[3] Castinetti F, Saveanu A, Reynaud R, et al. A novel dysfunctional LHX4 mutation wtih high phenotypical variability in patients with hypopituitarism[J]. J Clin Endocrinol Metab, 2008, 69(5):257-265.
[4] Pfaeffle RW, Hunter CS, Savage JJ, et al. Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies[J]. J Clin Endocrinol Metab, 2008, 93(3):1062-1071.
[5] Osorio MG, Marui S, Jorge AA, et al. Pituitary magnetic resonance imaging and function in patients with growth hormone deficiency with and without mutations in GHRH-R, GH-1, or PROP-1[J]. Clin Endocrinol Metab, 2002, 87(11):5076-5084.
[6] Qi Wei P, Hui Juan Z, Feng Ying G, et al. Magnetic resonance image of sellar region in pituitary stalk interruption syndrome in children and adolescents[J]. Acta Academiae Medicinae Sinicae, 2011, 33(1):9-13.
[7] Davis SW, Castinetti F, Carvalho LR, et al. Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes[J]. Mol Cell Endocrinol, 2010, 323(1):4-19.
[8] Arslanoğlu I, Kutlu H, Işgüven P, et al. Diagnostic value of pituitary MRI in differentiation of children with normal growth hormone secretion, isolated growth hormone deficiency and multiple pituitary hormone deficiency[J]. Pediatr Endocrinol Metab, 2001, 14(5):517-523.
[9] Kalina MA, Kalina-Faska B, Gruszczyńska K, et al. Usefulness of magnetic resonance findings of the hypothalamic-pituitary region in the management of short children with growth hormone deficiency: evidence from a longitudinal study[J]. Childs Nerv Syst, 2012, 28(1):121-127.
[10] Maghnie M, Salati B, Bianchi S, et al. Relationship between the morphological evaluation of the pituitary and the growth hormone (GH) response to GH-releasing hormone Plus arginine in children and adults with congenital hypopituitarism[J]. Clin Endocrinol Metab, 2001, 86(4):1574-1579.
[11] Tsai SL, Laffan E, Lawrence S. A retrospective review of pituitary MRI findings in children on growth hormone therapy[J]. Pediatr Radiol, 2012, 42(7):799-804.
[12] Maghnie M, Genovese E, Villa A, et al. Dynamic MRI in the congenital agenesis of the neural pituitary stalk syndrome: the role of the vascular pituitary stalk in predicting residual anterior pituitary function[J]. Clin Endocrinol (Oxf), 1996, 45(3):281-290.
[13] Di Iorgi N, Allegri AE, Napoli F, et al. The use of neuroimaging for assessing disorders of pituitary development[J]. Clin Endocrinol (Oxf), 2012, 76(2):161-176.
[14] Jagtap VS, Acharya SV, Sarathi V, et al. Ectopic posterior pituitary and stalk abnormality predicts severity and coexisting hormone deficiencies in patients with congenital growth hormone deficiency[J]. Pituitary, 2012, 15(2):243-250.
[15] 刘影, 李传福, 张杨. 垂体柄阻断综合征的MRI诊断[J]. 中华放射学杂志, 2005, 40(3): 2.
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