Abstract: Objective To explore the relevant factors and early complications of significantly elevated enzymes after off-pump coronary artery bypass grafting(OPCABG), in order to guide the perioperative management of patients. Methods A total of 214 patients who underwent OPCABG in our hospital during Jan. 2015 and June 2016 were enrolled. Postoperative creatine kinase MB(CK-MB)was detected at 12 h, 24 h and 48 h. Patients with CK-MB ≤5.31 ng/mL were classified into group A, and the others with CK-MB >5.31 ng/mL were classified into group B. The clinical data of the two groups were compared and analyzed with Logistic regression analysis. Results The relevant factors included occurrence of angina pectoris 24 h before operation, the graft located at the distal or middle-distal segment of left anterior descending artery(LAD), and operation time for bypass surgery. Group B had higher incidences of ECG ST segment change, hypotention, and perioperative myocardial infarction(PMI)than group A(P<0.05). Conclusions If preoperative angina pectoris is frequent, or the left internal mammary artery is bridged at the distal or middle-distal segment of LAD, or the graft time is too long, early complications such as significantly elevated enzymes, ECG ST segment changes, hypotension, and PMI may occur after OPCABG in patients with graft patency.

Key words: Creatine kinase MB, Relevant factors, Complications, Off-pump coronary artery bypass grafting