JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (10): 71-75.doi: 10.6040/j.issn.1671-7554.0.2016.1599

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Relevant factors and early complications of significantly elevated enzymes after off-pump coronary artery bypass grafting

LIANG Fei, ZHANG Wenlong, ZHANG Jun, XU Chongen, ZOU Chengwei   

  1. Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2016-12-01 Online:2017-10-10 Published:2017-10-10

Abstract: Objective To explore the relevant factors and early complications of significantly elevated enzymes after off-pump coronary artery bypass grafting(OPCABG), in order to guide the perioperative management of patients. Methods A total of 214 patients who underwent OPCABG in our hospital during Jan. 2015 and June 2016 were enrolled. Postoperative creatine kinase MB(CK-MB)was detected at 12 h, 24 h and 48 h. Patients with CK-MB ≤5.31 ng/mL were classified into group A, and the others with CK-MB >5.31 ng/mL were classified into group B. The clinical data of the two groups were compared and analyzed with Logistic regression analysis. Results The relevant factors included occurrence of angina pectoris 24 h before operation, the graft located at the distal or middle-distal segment of left anterior descending artery(LAD), and operation time for bypass surgery. Group B had higher incidences of ECG ST segment change, hypotention, and perioperative myocardial infarction(PMI)than group A(P<0.05). Conclusions If preoperative angina pectoris is frequent, or the left internal mammary artery is bridged at the distal or middle-distal segment of LAD, or the graft time is too long, early complications such as significantly elevated enzymes, ECG ST segment changes, hypotension, and PMI may occur after OPCABG in patients with graft patency.

Key words: Creatine kinase MB, Relevant factors, Complications, Off-pump coronary artery bypass grafting

CLC Number: 

  • R654.2
[1] Prestipino F, Spadaccio C, Nenna A, et al. Off-pump coronary artery bypass grafting versus optimal medical therapy alone: effectiveness of incomplete revascularization in high risk patients[J]. J Geriatr Cardiol, 2016, 13(1): 23-30.
[2] Al Ali J, Franck C, Filion KB, et al. Coronary artery bypass graft surgery versus percutaneous coronary intervention with first-generation drug-eluting stents: a meta-analysis of randomized controlled trials[J]. JACC Cardiovasc Interv, 2014, 7(5): 497-506.
[3] Hussain G, Azam H, Baig MA, et al. Early outcomes of on-pump versus off-pump coronary artery bypass grafting[J]. Pak J Med Sci, 2016, 32(4): 917-921.
[4] Domanski MJ. Prognostic implications of troponin T and creatinekinase-MB elevation after coronary artery bypass grafting[J]. Am Heart J, 2012, 164(5): 636-647.
[5] Mastro F, Guida P, Scrascia G, et al. Cardiac troponin I and creatine kinase-MB release after different cardiac surgeries[J]. J Cardiovasc Med(Hagerstown), 2015, 16(6): 456-464.
[6] Caliskan S, Besli F, Yildirim A, et al. The relationship between cardiotrophin-1 and troponin-i in coronary arterial bypass grafting on the beating heart: a prospective study[J]. Heart Surg Forum, 2015, 18(4): 146-150.
[7] 李瑾, 郑宏. 冠脉旁路移植术后心肌损伤标记物对术后死亡率影响的Meta分析[J]. 中国循证医学杂志, 2012, 12(7): 777-784. LI Jin, ZHENG Hong. Influence of myocardial injury markers on the mortality after coronary artery bypass grafting: a meta-analysis[J]. Chin J Evid-based Med, 2012,12(7): 777-784.
[8] 胡盛寿, 王小启, 宋云虎, 等. 常规与非体外循环下冠状动脉3支病变旁路移植血管通畅性对比分析[J]. 中华胸心血管外科杂志, 2002, 18(5): 295-297. HU Shengshou, WANG Xiaoqi, SONG Yunhu, et al. Comparative study on graft patency between off- pump and conventional coronary artery bypass grafting in the treatment of triple vessel coronary disease[J]. Chin J Thorac Cardiovasc Surg, 2002, 18(5): 295-297.
[9] Brown JM, Poston RS, Gammie JS, et al. Off-pump versus on-pump bypass coronary artery grafting in consecutive patients: decision-making algorithm and outcomes[J]. Ann Thorac Surg, 2006, 81(2): 555-561.
[10] Rahman MM, Alam MM, Jahan NA, et al. Prognostic role of multiple cardiac biomarkers in newly diagnosed acute coronary syndrome patients[J]. Mymensingh Med J, 2016, 25(2): 326-333.
[11] DErrigo P, Biancari F, Maraschini A, et al. Thirty-day mortality after coronary artery bypass surgery in patients aged <50 years: results of a multicenter study and meta-analysis of the literature[J]. J Card Surg, 2013, 28(3): 207-211.
[12] McFalls EO, Ward HB, Moritz TE, et al. Predictors and outcomes of a perioperative myocardial infarction following elective vascular surgery in patients with documented coronary artery disease: results of the CARP trial[J]. Eur Heart J, 2008, 29(3): 394-401.
[13] Udeh BL, Dalton JE, Hata JS, et al. Economic trends from 2003 to 2010 for perioperative myocardial infarction: a retrospective, cohort study[J]. Anesthesiology, 2014, 121(1): 36-45.
[14] Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction[J]. Circulation, 2012, 126(16): 2020-2035.
[15] Moussa ID, Klein LW, Shah B, et al. Consideration of a new definition of clinically relevant myocardial infarction after coronary revascularization: an expert consensus document from the Society for Cardiovascular Angiography and Interventions(SCAI)[J]. J Am Coll Cardiol, 2013, 62(17): 1563-1570.
[16] Jneid H, Alam M, Virani SS, et al. Redefining myocardial infarction: what is new in the ESC/ACCF/AHA/WHF third universal definition of myocardial infarction?[J]. Methodist Debakey Cardiovasc J, 2013, 9(3): 169-172.
[17] Di Giammarco G, Rabozzi R. Can transit-time flow measurement improve graft patency and clinical outcome in patients undergoing coronary artery bypass grafting?[J]. Interact Cardiovasc Thorac Surg, 2010, 11(5): 635-640.
[18] Yu Y, Zhang F, Gao MX, et al. The application of intraoperative transit time flow measurement to accurately assess anastomotic quality in sequential vein grafting[J]. Interact Cardiovasc Thorac Surg, 2013, 17(6): 938-943.
[19] Matija Jelenc, Blaž Jelenc, Tomislav Klokocovnik, et al. Understanding coronary artery bypass transit time flow curves: role of bypass graft compliance[J]. Interact Cardiovasc Thorac Surg, 2014, 18(2): 164-168.
[20] 高长青, 张涛, 李伯君, 等. OPCAB即时与关胸时乳内动脉桥血流的对比研究[J]. 中华胸心血管外科杂志, 2003, 19(3): 136-138. GAO Changqing, ZHANG Tao, LI Bojun, et al. Intraoperative comparison of left internal mammary artery blood flow: immediately after implantation versus before sternum closure[J]. Chin J Thorac Cardiovasc Surg, 2003, 19(3): 136-138.
[21] Gurné O, Chenu P, Buche M, et al. Adaptive mechanisms of arterial and venous coronary bypass grafts to an increase in flow demand[J]. Heart, 1999, 82(3): 336-342.
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