JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (5): 56-60.doi: 10.6040/j.issn.1671-7554.0.2017.149

Previous Articles     Next Articles

Evaluation of the effects of high blood pressure on white matter lesion in young adults using diffusion tensor imaging

ZHANG Hua1, ZHUANG Xia2, LIU Zhendong1, DIAO Yutao1, DU Jiachen3, CUI Yi3   

  1. 1. Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China;
    2. Dezhou Municipal Commission of Health and Family Planning, Dezhou 253000, Shandong, China;
    3. Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2017-02-21 Online:2017-05-10 Published:2017-05-10

PDF (PC)

255

Abstract: Objective To explore subtle white matter lesions in young hypertensive adults using magnetic resonance diffusion tensor imaging(DTI). Methods Routine brain MRI and DTI sequences were performed in participants with hypertension(n=45, hypertension group)and controls with normal blood pressure (n=45, control group). Fractional anisotropy(FA)values of centrum ovale, cerebral peduncle, corona radiata, genu of corpus callosum, splenium of corpus callosum, corpus callosum body, anterior limb of internal capsule, posterior limb of internal capsule, bilateral frontal lobe, parietal lobe, temporal lobe and occipital lobe were measured. Results Compared with the control group, the hypertension group had significantly decreased FA values in the cerebral peduncle and frontal lobe(P<0.001). FA values in the cerebral peduncle and frontal lobe were negatively correlated with systolic blood pressure(r=-0.625, r=-0.665, P<0.001; r=-0.417, r=-0.495, P<0.05). FA values of the other regions of the white matter were not correlated with either systolic pressure or diastolic pressure(P>0.05). Conclusion The microstructural white matter in young adults with hypertension may be selectively impaired, indicating the need for early and optimum control of blood pressure.

Key words: Young adults, White Matter Lesion, Hypertension, Diffusion Tensor Imaging

CLC Number: 

  • R814.42
[1] Moran C, Phan TG, Srikanth VK. Cerebral small vessel disease: a review of clinical, radiological, and histopathological phenotypes[J]. Int J Stroke, 2012, 7(1): 36-46.
[2] Maillard P, Seshadri S, Beiser A, et al. Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study[J]. Lancet Neurol, 2012, 11(12): 1039-1047.
[3] 国家心血管病中心. 中国心血管病报告2015[M]. 北京: 中国大百科全书出版社, 2016.
[4] Mascalchi M, Pantoni L, Giannelli M, et al. Diffusion tensor imaging to map brain microstructural changes in CADASIL[J]. J Neuroimaging, 2017, 27(1): 85-91.
[5] Pasi M, van Uden IW, Tuladhar AM, et al. White matter microstructural damage on diffusion tensor imaging in cerebral small vessel disease: clinical consequences[J]. Stroke, 2016, 47(6): 1679-1684.
[6] Genc S, Steward CE, Malpas CB, et al. Short-term white matter alterations in Alzheimers disease characterized by diffusion tensor imaging[J]. J Magn Reson Imaging, 2016, 43(3): 627-634.
[7] Hsu JL, Chen WH, Bai CH, et al. Microstructural white matter tissue characteristics are modulated by homocysteine: a diffusion tensor imaging study[J]. PLOS One, 2015, 10(2): 1-14.
[8] Hope TR, Vardal J, Biomeud A, et al. Serial diffusion tensor imaging for early detection of radiation-induced injuries to normal-appearing white matter in high-grade glioma patients[J]. J Magn Reson Imaging, 2014, 26(1): 136-139.
[9] Chen P, Jiang T, Ouyang J, et al. Glucoeorticoid receptor auto-upregulation and its relation with glucocorticoid sensitivity in idiopathic nephrotic syndrome[J]. Int Urol Nephrol, 2011, 43(1): 167-174.
[10] Yuan W, McKinstry RC, Shimony JS, et al. Diffusion tensor imaging properties and neurobehavioral outcomes in children with hydrocephalus[J]. AJNR Am J Neuroradiol, 2013, 34(2): 439-445.
[11] 中国高血压防治指南修订委员会. 中国高血压防治指南2010[J]. 中华心血管病杂志, 2011, 39(7): 579-615.
[12] 王建华, 吕佩源, 王贺波, 等. DTI评价轻度认知障碍及轻中度阿尔茨海默病脑白质微细结构损害的研究[J]. 中国神经免疫学和神经病学杂志, 2010, 17(3): 211-214. WANG Jianhua, LÜ Peiyuan, WANG Hebo, et al. Study of microstructural white matter lesions in patients with mild cognitive impairment and mild and moderate Alzheimer disease[J]. Chin J Neuriommunol & Neurol, 2010, 17(3): 211-214.
[13] Pagonabarraga J, Kutisevsky J. Cognitive impairment and dementia in Parkinsons disease[J]. NeurobioI Dis, 2012, 46: 590-596.
[14] Sorg SF, Delano-Wood L, Luc N, et al. White matter integrity in veterans with mild traumatic brain injury: associations with executive function and loss of consciousness[J]. J Head Trauma Rehabil, 2014, 29(1): 21-32.
[15] Solomon SD, Verma A, Desai A, et al. Effect of intensive versus standard blood pressure lowering on diastolic function in patients with uncontrolled hypertension and diastolic dysfunction[J]. Hypertension, 2010, 55(2): 241-248.
[16] Le Bihan D, Mangin JF, Poupon C, et al. Diffusion tensor imaging: Concepts and applications[J]. Magn Reson Imaging, 2010, 13(4): 534-536.
[17] Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges[J]. Lancet Neurol, 2010, 9(7): 689-701.
[18] Weller RO, Hawkes CA, Kalaria RN, et al. White matter changes in dementia: role of impaired drainage of interstitial fluid[J]. Brain Pathol, 2015, 25(1): 63-78.
[19] 李伟, 朱莉. 高血压患者脑结构/功能改变及其与认知功能障碍关系的研究进展[J]. 实用心脑肺血管病杂志, 2015, 23(5): 47-49. LI Wei, ZHU Li. Changes of brain structure and function and its correlation with cognition disorders in hypertension patients[J]. Practical Journal of Cardiac Cerebral, 2015, 23(5): 47-49.
[20] Verhaaren BF, Vernooij MW, de Boer R, et al. High blood pressure and cerebral white matter lesion progression in the general population[J]. Hypertension, 2013, 61(6):1354-1359.
[21] Bolandzadeh N, Davis JC, Tam R, et al. The association between cognitive function and white matter lesion location in older adults: a systematic review[J]. BMC Neurol, 2012, 12:126. doi: 10.1186/1471-2377-12-126.
[22] Smits M, Houston GC, Dippel DW, et al. Microstmctural brain injury in post-concHssioD syndrome after minor head injury[J]. Neuroradiology, 2011, 53(8): 553-563.
[23] Van Norden AG, de Laat KF, van Dijk EJ, et al. Diffusion tensor imaging and cognition in cerebral small vessel disease: the RUN DMC study[J]. Biochim Biophys Acta, 2012, 1822(3): 401-407.
[24] Gorelick PB, Scuteri A, BIack SE, et al. Vascular contributions to cognitive impairment and dementia: a statement for health care professionals from the American Heart Association/American Stroke Association[J]. Stroke, 2011, 42(9): 2672-2713.
[25] Kwon HG, Hong JH, Jang SH. Anatomic location and somatotopic arrangement of the corticospinal tract at the cerebral peduncle in the human brain[J]. AJNR Am J Neuroradiol, 2011, 32(11): 2116-2119.
[1] WUYi-Na, GE Zhi-Ming, LI Fang, HE Hong, JIANG Hong, ZHANG Yun. Expressions of angiotensin converting enzyme 2 mRNA and protein in the kidneys in spontaneously hypertensive rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 5-.
[2] DU Futian, DU Yunlong, LIN Hongfeng. A clinical research on occlusive techniques for partial splentic embolization combined with radiofrequency ablation for hypersplenism due to portal hypertension [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 79-83.
[3] YU Tao, LIU Huanle, FENG Xin, XU Fuyin, CHEN Yafei, XUE Fuzhong, ZHANG Chengqi. A hypertension risk prediction model based on health management cohort [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(6): 61-65.
[4] YAN Fangying, SHAN Xiaolan, LI Jingyuan, ZHANG Jie, YAN Xuefang, YANG Yi, BU Peili. Pioglitazone ameliorates cardiac fibrosis induced by hypertension via regulating Sirt3 [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 13-18.
[5] ZHANG Luan, CHEN Ou, LUAN Yun, ZHU Xiaobo, CHEN Yuan, WANG Yibiao. Effects of gemigliptin on the therapeutic effect and inflammatory factors of monocrotaline-induced pulmonary arterial hypertension in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 19-22.
[6] LI Rui, MA Weihong, REN Manyi, ZHAO Mengmeng, JIANG Shan, JU Yuanyuan, GUO Ying, SUN Zhaohui, SUI Shujian. Correlation between TWEAK and cardiac remodeling in essential hypertensive patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 49-55.
[7] XU Tianyi, WU Ping, WANG Ailing, CHEN Liping. Clinical effect of milrinone atomization inhalation on treating severe pneumonia complicated with heart failure of neonates and infants [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(7): 88-90.
[8] WANG Lixuan, ZHANG Lu, XU Xin, LI Sixue, LIU Min, WANG Yaping, MA Huijuan. Chronic intermittent hypobaric hypoxia enhances the vasodilatation of thoracic aorta via PI3K-dependent eNOS activation in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 11-15.
[9] PAN Yanyan, SUN Yongchao, ZHAO Cuifen, KONG Qingyu. Clinical efficacy of bosentan in the treatment of babies with congenital heart disease complicated with pulmonary hypertension [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 53-56.
[10] LIU Huimin, LIU Deng, LI Xiaoyu, ZOU Shufeng, JIANG Limin, LI Yuhuan. Effect of Lobelia alkaloids on endothelin-1 signal pathway in a rat model of pulmonary arterial hypertension [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(8): 1-4.
[11] ZHANG Nan, ZHOU Lixiao, SUN Chenglin. Protective effect of riluzole on the damage of rat retina induced by acute intraocular hypertension [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(8): 27-31.
[12] TANG Mengmeng, JIN Nüwa, LIU Chuanzhen, LIU Kai, CAO Guangqing, WANG He, PANG Xinyan, WU Shuming. Effects of ethyl pyruvate in the treatment of hyperkinetic pulmonary hypertension [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 75-80.
[13] XU Zhongyang, WANG Liqi, XU Zhenxing, ZHAO Qian, ZHU Shiming. Correlations among RhoA/ROCK signaling pathway, blood pressure variability and carotid artery intima-media thickness in essential hypertensive patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 48-51.
[14] YU Huihui, LEI Zhen, WANG Shukang, PAN Fang. Negative emotion and related factors in elderly patients with comorbidity of hypertension and diabetes [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(12): 81-85,96.
[15] HUANG Xiaohua, GUO Qing, ZHAO Yanping, MA Liang, WANG Jiugang, Siqingerile, JING Shuanglong, LI Qingyang. Clinical observation on effects of combined prescription of Mongolian medicine and Western medicine in treatment of senile hypertension [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(S2): 13-15.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd