JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (2): 48-51.doi: 10.6040/j.issn.1671-7554.0.2014.768

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Correlations among RhoA/ROCK signaling pathway, blood pressure variability and carotid artery intima-media thickness in essential hypertensive patients

XU Zhongyang, WANG Liqi, XU Zhenxing, ZHAO Qian, ZHU Shiming   

  1. Department of Cardiology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China
  • Received:2014-10-30 Published:2015-02-10

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Abstract: Objective To investigate the association of the blood pressure variability (BPV) and carotid intima-media thickness (IMT) with the Rho/ROCK signaling pathway in essential hypertensive patients. Methods A total of 73 hypertensive patients were divided into two groups based on serum level of ROCK1: group with high level of ROCK1 (n=37) and group with low level of ROCK1 (n=36), and 40 healthy subjects were selected as the control group. The serum level of ROCK1 was measured with Human Rock1 Elisa kit and microplate reader. The mean blood pressures (systolic and diastolic) and the standard deviations of 24 h, daytime and nighttime (24hSSD, dSSD, nSSD, 24hDSD, dDSD and nDSD) were monitored. The carotid artery IMT was determined with color Doppler ultrasound monitor. Results The serum level of ROCK1 in hypertensive group was higher than that of the control group (P<0.05). Compared with the group with low ROCK1 level, the 24hSSD, dSSD and nSSD were significantly increased in the group with high ROCK1 level (P<0.05). The carotid artery IMT in hypertensive patients was thicker than that of control group (P<0.05). The carotid artery IMT of the group with high ROCK1 level was thicker than that of the group with low ROCK1 level (P<0.05). The serum level of ROCK1 showed significant positive correlations with 24hSSD, dSSD, nSSD and carotid artery IMT in hypertensive patients (P<0.05). Conclusion The BPV is closely correlated with expression of Rho/ROCK signaling pathway in hypertensive patients. Overexpression of Rho/ROCK signalingpathway plays a key role in the progression of carotid artery IMT and atherosclerosis.

Key words: RhoA/ROCK, Intima-media thickness, Hypertension, Blood pressure variability, Atherosclerosis, Ambulatory blood pressure monitoring

CLC Number: 

  • R544.1
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