JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (2): 43-47.doi: 10.6040/j.issn.1671-7554.0.2014.543

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Relationship between microalbuminuria and brain damage in patients with type 2 diabetes mellitus

HU Fangzhi1, ZHANG Zhengjun2, GENG Houfa2, LIANG Qiuhua2, SUN Lin2   

  1. 1. Jining Medical University, Jining 272029, Shandong, China;
    2. Department of Endocrinology, Affiliated Hospital of Jining Medical College, Jining 272029, Shandong, China
  • Received:2014-08-19 Published:2015-02-10

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Abstract: Objective To investigate the cerebral metabolic changes in basal ganglia and semi oval center using proton magnetic resonance spectroscopy(1H-MRS) in order to prove that microalbuminuria is an early marker of brain tissue damage in patients with type 2 diabetes mellitus (T2DM). Methods With reference to the urinary albumin excretion ratio (UAER), 61 patients with newly diagnosed T2DM were divided into the normal microalbuminuria group (DM group, UAER<20 μg/minute, n=29) and microalbuminuria group (DA group, 20 μg/min≤UAER<200 μg /min, n=32). Meanwhile, 20 healthy controls (HC group) were enrolled. Conventional magnetic resonance imaging (MRI) and 1H-MRS were performed on all participants. Results In the basal ganglia area, NAA/Cr ratio of the DA group was significantly lower than that of the DM and HC group; NAA/Cr ratio of the DM group was markedly lower than that of the HC group; Cho/Cr ratio was remarkably increased in the DA group compared with the HC group (P<0.05). In the semi oval center area, NAA/Cr ratio of the DA group was significantly lower than that of the HC group; MI/Cr ratio was notedly higher in the DA group compared with the DM and HC group (P<0.05). NAA/Cr ratio of the DA group in the basal ganglia was negatively correlated with the level of UAER (r=-0.768, P<0.05). Conclusion T2DM patients with elevated microalbuminuria are more prone to brain tissue damage.

Key words: Proton magnetic resonance spectroscopy, Semi oval center, Microalbuminuria, Basal ganglia, Type 2 diabetes mellitus

CLC Number: 

  • R578.2
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