JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (5): 88-91.doi: 10.6040/j.issn.1671-7554.0.2015.927

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Changes of carotid artery structure and function in children with primary nephrotic syndrome

WANG Dan1, QI Hengtao2, SUN Shuzhen1   

  1. 1. Department of Pediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. Shandong Medical Imaging Research Institute, Jinan 250021, Shandong, China
  • Received:2015-09-29 Online:2016-05-16 Published:2016-05-16

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Abstract: Objective To explore the changes of carotid artery structure and function as early indicators of atherosclerosis(AS)in children with primary nephrotic syndrome(PNS). Methods Between Feb.2013 to Dec. 2014, 122 children with PNS(82 in active state, 40 in remission state), and 40 healthy controls were enrolled. Carotid ultrasonography, serum albumin, serum lipid and 24-hour urine protein quantity of all subjects were determined. The results collected were analyzed with variance analysis, Spearsman rank correlation test, and multiple stepwise regression analysis. Results Compared with the controls, patients in active state had significantly higher carotid intima-media thickness(cIMT), carotid stiffness coefficient(β), mean wall cross-sectional area(WCSA), but lower carotid artery movement(△D)(all P<0.05). There was a positive correlation between cIMT and disease relapse number(r=0.29, P<0.01). Multiple stepwise regression analysis showed that cIMT was associated with total cholesterol(TC)and lipoprotein(a)［Lp(a)］(R2=0.22, β=0.01, P<0.01; β=0.03, P=0.02). Conclusion Carotid artery structure and function are changed in children with PNS, and the risks for AS are increased. cIMT can be used to predict the potential risk of AS, which is associated with lipid metabolism disorder and disease relapse.

Key words: Primary nephrotic syndrome, Atherosclerosis, Carotid intima-media thickness, Lipid disorders

CLC Number: 

  • R729.6
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