JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (5): 10-14.doi: 10.6040/j.issn.1671-7554.0.2015.271

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Effects of atorvastatin with intravascular ultrasound on atherosclerotic plaques in rabbits

TAN Bei1, GUAN Yuqing2, SUN Hui2, HU Keqing2, SU Guohai2, WEI Min3   

  1. 1. School of Medicine, Jinan 250012, Shandong, China;
    2. Department of Cardiology;
    3. Department of Supplies, Jinan Central Hospital, Shandong University, Jinan 250013, Shandong, China
  • Received:2015-03-13 Revised:2015-05-04 Online:2015-05-10 Published:2015-05-10

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Abstract: Objective To explore the effects of different doses of atorvastatin on atherosclerotic plaques in rabbit models with intravascular ultrasound. Methods A total of 30 New Zealand white rabbits were randomized into the control group (n=7), model group (n=7), low-dosage atorvastain group (n=8) and high-dosage atorvastain group (n=8). Except for the control group, the other groups were fed with high-fat diet for 8 weeks, and aortaventralis balloon-dilation injury was created to establish AS models. Intravascular ultrasound (IVUS) was performed at the end of the 8th week. After that, the model group continued to eat high-fat diet, while the two atorvastatin groups received 2-week extra atorvastatin intervention. At the end of the 10th week, all rabbits were sacrificed. Venous blood was drawn to measure serum lipid, and the amount of inflammation mediator hs-CRP was quantified with ELISA. The abdominal aortae were detected with IVUS and then observed pathologically. Results At the end of study, serum lipid in the control group was significantly lower than that in the other three groups (P<0.05). Compared with model group, the level of serum lipid and hs-CRP decreased significantly in two atorvastatin groups, which were more significant in high-dosage atorvastain group (P<0.01). Extra-elastic membranous area (EEMA), plaque area (PA), and lumen area stenosing (LAS%) in the model group were significantly higher than those in the two atorvastatin groups (P<0.05), with nosignificant difference in lumen area between the model group and the two atorvastatin groups (P>0.05). Conclusion Atorvastatin is able to control the level of serum lipid observably and reduce the plaque formation in atherosclerotic rabbit models.

Key words: Atorvastatin, Plaque, Intravascular ultrasound, Atherosclerosis, Rabbits

CLC Number: 

  • R541.4
[1] Cheng JM, Oemrawsingh RM, Garcia-Garcia HM, et al. Relation of C-reactive protein to coronary plaque characteristics on grayscale, radiofrequency intravascular ultrasound, and cardiovascular in patients with acute coronary syndrome or stable angina pectoris (from the ATHEROREMO-IVUS study)[J]. AM J Cardiol, 2014, 114(10): 1497-1503.
[2] Kwang K. Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability[J]. Cardio Res, 2000, 47(4): 648-657.
[3] 陈文强, 张立, 张梅. 血管内超声和病理学分析对比研究动脉粥样硬化兔不稳定斑块的破裂和血栓形成[J]. 中华超声和影像学杂志, 2004, 13(10): 777-779. CHEN Wenqiang, ZHANG Li, ZHANG Mei. Intravascular ultrasound versus pathologic analysis in detecting atherosclerotic plaque distruption and arterial thrombosis[J]. Chinese Journal of Ultarsonography, 2014, 13(10): 777-779.
[4] 仲琳, 张运, 张梅. 兔动脉粥样硬化易损斑块模型的建立[J]. 基础医学与临床, 2005, 25(4): 370-373. ZHONG Lin, ZHANG Yun, ZHANG Mei. An experimental study on vulnerable atherosclerotic plaques with intravascular ultrasound[J]. Basic and Clinical Medicine, 2005, 25(4): 370-373.
[5] 康卫平, 王萍, 王雪梅, 等. 兔腹主动脉粥样硬化模型的建立[J]. 临床医药实践杂志, 2007, 34(11): 1062-1064.
[6] Koivisto T, Vanninen R, Hurskainen H, et al. Outcomes of early endovascular versus surgical treatment of ruptured cerebral aneurysms: a prospective randomized study[J]. Stroke, 2000, 31(10): 2369-2377.
[7] Parolari A, Tremoli E, Cavallotti L, et al. Do statins improve outcomes and delay the progression of non-rheumatic calcific aortic stenosis[J]. Heart, 2011, 97(7): 523-529.
[8] van der Loo B, Spring S, Koppensteiner R. High-dose atorvastatin treatment in patients with peripheral arterial disease: effects on platelet aggregation, blood rheology and plasma homocysteine[J]. Clin Hemorheol Microcirc, 2011, 47(4): 241-251.
[9] 李建勇, 胡大一, 史旭波, 等. 不同剂量阿托伐他汀对冠心病患者的疗效和安全多中心研究[J]. 中华心血管病杂志, 2005, 33(12): 1085-1087.
[10] Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methyl-glutaryl cozezyme a reductase inhibitors[J]. Arterioscler Thromb Vasc Biol, 2001, 21(10): 1712-1719.
[11] 李悦妍, 关玉庆, 苗伟, 等. 阿托伐他汀对动脉粥样硬化模型兔toll样受体4及其下游信号表达的影响[J]. 山东大学学报:医学版, 2014, 52(6): 1-6. LI Yueyan, GUAN Yuqing, MIAO Wei, et al. Effect of atorvastatin on TLR4 expression and downstream signaling in atherosclerotic rabbits[J]. Journal of Shandong University: Health Sciences, 2014, 52(6): 1-6.
[12] Nissen SE, Nicholls SJ, Sipahi I, et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial[J]. JAMA, 2006, 295(13): 1556-1565.
[13] Leanne Satchell, David S. Oxidation of Low-density lipoprotein by Iron at lysosomal PH: implication for atherosclerosis[J]. Biochemistry, 2012, 51(18): 3767-3775.
[14] Ross R. Atherosclerosis-an inflammatory disease[J]. N Engl J Med, 1999, 340(2): 115-126.
[15] Thiele JR, Habersberger J, Braig D, et al. Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy[J]. Circulation, 2014, 130(1): 35-50.
[16] Sigueira DA, Sousa AG, Costa Junior Jde R, et al. Correlation between plaque composition as assessed by virtual histology and C-reactive protein[J]. Arg Bras Cardiol, 2013, 101(1): 78-86.
[17] Koenig W. High-sensitivity C-reactive protein and atherosclerotic disease: from improved risk prediction to risk-guided therapy[J]. Int J Cardiol, 2013, 168(6): 5126-5134.
[18] Wang C, Yan J, Yang P, et al. The relationship between CD40 gene polymorphism and unstable coronary atherosclerotic plaques[J]. Clin Cardiol, 2010, 33(6): E55-60.
[19] Davies MJ. Pathophysiology of acute coronary syndrome[J]. Heart, 2000, 83: 361-366.
[20] Nissen SE, Yock P. Intravascular ultrasound: novel pathophysiological insights and current clinical applications[J]. Circulation, 2001, 103(4): 604-616.
[21] Escolar E, Weigold G, Fuisz A, et al. New imaging techniques for diagnosing coronary artery disease[J]. CAMJ, 2006, 174(8): 487-495.
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