JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (5): 10-14.doi: 10.6040/j.issn.1671-7554.0.2015.271

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Effects of atorvastatin with intravascular ultrasound on atherosclerotic plaques in rabbits

TAN Bei1, GUAN Yuqing2, SUN Hui2, HU Keqing2, SU Guohai2, WEI Min3   

  1. 1. School of Medicine, Jinan 250012, Shandong, China;
    2. Department of Cardiology;
    3. Department of Supplies, Jinan Central Hospital, Shandong University, Jinan 250013, Shandong, China
  • Received:2015-03-13 Revised:2015-05-04 Online:2015-05-10 Published:2015-05-10

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Abstract: Objective To explore the effects of different doses of atorvastatin on atherosclerotic plaques in rabbit models with intravascular ultrasound. Methods A total of 30 New Zealand white rabbits were randomized into the control group (n=7), model group (n=7), low-dosage atorvastain group (n=8) and high-dosage atorvastain group (n=8). Except for the control group, the other groups were fed with high-fat diet for 8 weeks, and aortaventralis balloon-dilation injury was created to establish AS models. Intravascular ultrasound (IVUS) was performed at the end of the 8th week. After that, the model group continued to eat high-fat diet, while the two atorvastatin groups received 2-week extra atorvastatin intervention. At the end of the 10th week, all rabbits were sacrificed. Venous blood was drawn to measure serum lipid, and the amount of inflammation mediator hs-CRP was quantified with ELISA. The abdominal aortae were detected with IVUS and then observed pathologically. Results At the end of study, serum lipid in the control group was significantly lower than that in the other three groups (P<0.05). Compared with model group, the level of serum lipid and hs-CRP decreased significantly in two atorvastatin groups, which were more significant in high-dosage atorvastain group (P<0.01). Extra-elastic membranous area (EEMA), plaque area (PA), and lumen area stenosing (LAS%) in the model group were significantly higher than those in the two atorvastatin groups (P<0.05), with nosignificant difference in lumen area between the model group and the two atorvastatin groups (P>0.05). Conclusion Atorvastatin is able to control the level of serum lipid observably and reduce the plaque formation in atherosclerotic rabbit models.

Key words: Atorvastatin, Plaque, Intravascular ultrasound, Atherosclerosis, Rabbits

CLC Number: 

  • R541.4
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