JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (5): 1-4.doi: 10.6040/j.issn.1671-7554.2.2015.001

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Immune-regulation of statins in atherosclerosis and opinions on its clinical applications

DUAN Ruisheng   

  1. Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong, China
  • Received:2015-02-24 Revised:2015-04-07 Online:2015-05-10 Published:2015-05-10

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Abstract: It has been demonstrated that the pathogenesis of atherosclerosis is characteristic of inflammation and immune responses, which includes innate and adaptive immune responses to oxidative lipoprotein. The immune cells in the atherosclerotic plaque include macrophages, CD4+ and CD8+ T cells, B cells, dendritic cells, regulatory T cells, NK cells, neurophils and mast cells. Statins have anti-inflammatory and immune suppressive roles and have been applied in the treatment of autoimmune diseases. The statin benefit observed in the atherosclerosis is due to both lipid-lowing and anti-inflammatory effects. Hypersensitive C-reactive protein (hsCRP), an inflammatory marker of atherosclerosis, and low-density lipoprotein cholesterol (LDL-C) are equally strong predictors of cardiovascular risk. Both LDL-C and hsCRP should be monitored in the prevention and treatment of atherosclerosis.

Key words: Immune responses, Atherosclerosis, Statins, Hypersensitive C-reactive protein

CLC Number: 

  • R543.5
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