JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (12): 76-80.doi: 10.6040/j.issn.1671-7554.0.2015.417

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Application of DCE-MRI in the quantitative measurement of neovascularization in carotid atherosclerotic plaque

LIU Guoming1,2, SHI Hao1, CHENG Haichao1   

  1. 1. Department of Medical Imaging, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China;
    2. Institute of Technology, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
  • Received:2015-04-27 Online:2015-12-10 Published:2015-12-10

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Abstract: Objective To evaluate neovascularization by measuring the volume transfer constant (Ktrans) of the different components in carotid atherosclerosis plaques after DCE-MRI dynamic contrast-enhanced magnetic resonance imaging, in order to provide evidence to determine plaque stability and quantitative measurement of neovascularization. Methods A total of 41 patients with suspected atherosclerotic plaques in carotid arteries were scanned with MRI and DCE-MRI, and then divided into different groups according to each component signal:fibrosis group, calcification group, recent hemorrhage group and lipid core group. Data of dynamic enhancement were treated with a post processing procedure to evaluate and compare the volume transfer constant (Ktrans) of various components in the plaques. Results There were different Ktrans values in different groups:0.591/min in fibrosis group, 0.031/min in calcification group, 0.115/min in recent hemorrhage group, and 0.048/min in lipid core group. There was no difference between the lipid core and recent hemorrhage groups (P>0.05), but there were differences between the other groups (P<0.05). Conclusion Ktrans value in different components can reflect the different permeability and blood supply. It can be used as an indicator to assess the plaque stability and neovascularization.

Key words: Carotid atherosclerotic plaques, Neovascularization, DCE-MRI, Quantitative measurement

CLC Number: 

  • R445
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