JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (5): 81-85.doi: 10.6040/j.issn.1671-7554.0.2016.1676

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Clinical effects of body mass index on ovulation induction treatment with letrozole among women with polycystic ovary syndrome

ZHANG Suping1,2, WANG Ze1, ZHOU Yali3, LI Jing1, LU Xilan4, BAI Hongwei4, SHI Yuhua1   

  1. 1. Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan 250001, Shandong, China;
    2. Department of Gynaecology, Zoucheng Peoples Hospital, Zoucheng 273500, Shandong, China;
    3. Department of Obstertrics and Gynecology, Caoxian County Hospital, Caoxian 274400, Shandong, China;
    4. Center for Reproductive Medicine, Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China
  • Received:2016-12-19 Online:2017-05-10 Published:2017-05-10

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Abstract: Objective To compare the clinical effects of body mass index(BMI)on ovulation induction treatment with letrozole among women with polycystic ovary syndrome(PCOS). Methods A total of 153 infertile PCOS women treated during Jan. 2014 and Dec. 2015 were enrolled. These women were divided into obese group(n=71)and non-obese group(n=82)according to their BMI. The stimulation was initiated by letrozole at a dose of 5mg daily for 5 days, beginning from day 2 to day 4 of the menstrual cycle. The ovulation induction outcomes of the two groups were compared. Results The obese group had significantly higher serum glucose, insulin, triglyceride, high density lipoprotein(HDL), and total cholesterol level than the non-obese group(P=0.020, <0.001, =0.002, <0.001, =0.028). On the day when human chorionic gonadotropin(HCG)was administered, estradiol(E2)was statistically lower in the obese group than in the non-obese group(P=0.026). There were no differences in the number of dominant follicles, ovulation rate, luteinizing hormone(LH)level on the HCG day, progesterone level, pregnancy rate, miscarriage rate and live birth rate between the two groups(P>0.05). Conclusion Letrozole is an effective ovulation induction agent for infertile PCOS women with different MBI by improving the ovulation and pregnancy rate.

Key words: Polycystic ovary syndrome, Letrozole, Body mass index, Live birth rate, Obesity

CLC Number: 

  • R588
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