JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (5): 76-80.doi: 10.6040/j.issn.1671-7554.0.2017.191

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Correlation between hyperuricemi, Helicobacter pylori infection and metabolic syndrome

YU Zhenzhen1,2, CHEN Hui3, YANG Xiaoyun4, LÜ Ming1,3   

  1. 1. Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Health Examination Center;
    3. Department of Clinical Research;
    4. Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2017-03-05 Online:2017-05-10 Published:2017-05-10

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Abstract: Objective To explore the correlation among serum uric acid(SUA), infection of helicobacter pylori (Hp)and metabolic syndrome(MS)in order to provide epidemiological evidences to reduce incidence of MS. Methods A cross-sectional study was conducted on 8 541 patients who met the inclusion standard, including 5 117 male and 3 424 female, aged 20~80(average 47.99±11.95)years. C-13 breath test-Hp and fasting blood biochemical examinations were conducted. The patients were divided into 2 groups, MS group(n=1 442)and non-MS(n=7 099), according 山 东 大 学 学 报 (医 学 版)55卷5期 -于珍珍,等.高尿酸血症、幽门螺杆菌感染与代谢综合征的相关性 \=-to the diagnostic criteria issued by Chinese Diabetes Society(CDS). According to age, the patients were divided into 3 groups: youth group(≤ 44 years), middle-aged group(45-59 years)and elderly group(≥ 60 years). According to the level of SUA, the patients were divided into SUA group and hyperuricemia(HUA)group. According to Hp status, the patients were divided into Hp+ and Hp- groups. According to the combination of SUA and HUA, the patients were divided into Hp- SUA, Hp+ SUA, Hp- HUA, and Hp+ HUA groups. The relationship between SUA, Hp infection and MS was analyzed with odds ratio and chi-square test. Results In the MS group, the male and female incidence rate was 22.1% and 9.0%, respectively, with statistical difference(P<0.05). The body mass index(BMI), systolic pressure(SBP), diastolic pressure(DBP), fasting blood glucose(FBG), triglyceride(TG)and Hp+ of MS group were higher than those of non-MS group(P<0.05), while high-density lipoprotein cholesterol(HDL-C)was lower than that of non-MS(P<0.001). Sex, age and Hp infection were related to HUA and MS, but not to MS(P<0.05). In both male and female groups, Hp infection was not related to MS; HUA and HUA complicated with Hp infection increased the incidence of MS(P<0.05). Hp infection increased the incidence of MS in the elderly group(P<0.05); HUA and HUA complicated with Hp infection increased the incidence of MS in all age groups(P<0.05). Conclusion Gender and age are closely related to MS; HUA and Hp infection are risk factors of MS.

Key words: Hyperuricemia, Helicobacter pylori, Metabolic syndrome, Infection, Physical examination

CLC Number: 

  • R181.3
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