JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (11): 73-76.doi: 10.6040/j.issn.1671-7554.0.2015.312

• Clinical Medicine • Previous Articles     Next Articles

Clinical analysis and type distribution of human papilloma virus among gynecologic outpatients

LI Chen1, CHENG Yufeng1, LI Ailu2   

  1. 1. Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Obstetrics and Gynecology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, Fujian, China
  • Received:2015-03-23 Online:2015-11-10 Published:2015-11-10

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Abstract: Objective To explore the infection rate and characteristics of human papilloma virus (HPV) among gynecologic outpatients, distribution of HPV types, and the relationship between HPV and cervical neoplasms. Methods Flow-through hybridization and gene chip ttechnique was employed to detect HPV genotypes of 5 869 gynecologic outpatients. Results The total infection rate was 23.6%, the detection rate of HR-HPV and LR-HPV was 19.6% and 6.7%, respectively. The most common type of HPV was HPV16, followed by 52, 11, 58, 6, 18, 53 and 33. Of the 1,385 HPV cases, 72.1% acquired single subtype of HPV, 21.3% had two different subtypes, and 6.6% had more than three different subtypes. HPV infection rate in patients with cervical cancer (91.7%) was significantly higher than that in patients with cervicitis (χ2=207.426, P<0.001) and healthy controls (χ2=252.211, P<0.001). HPV16,18, 31, 33, 58 and 45 were most commonly found in patients with cervical cancer. HPV infection rate was significant (χ2=36.486, P<0.01) in different age groups, the highest (32.5%) was in women under 25 years old, followed by 28.4% in women above 50 years old. Conclusion Among gynecologic HPV outpatients, most were infected with HR-HPV, some with LR-HPV, and a few with both HR- HPV and LR-HPV or with multiple HPV. There were obviousregional differences and characteristics of HPV type distribution in different population groups. The highest rate of HPV infection was in patients with cervical cancer. HPV 16, 18, and other HR- HPV were found to be closely related with cervical lesions and cervical cancer. Women under 25 and above 50 years old were high-risk groups.

Key words: Cervical neoplasms, Viral infection, Human Papillioma Virus, Gene chips

CLC Number: 

  • R737.33
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