JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (11): 73-76.doi: 10.6040/j.issn.1671-7554.0.2015.312

• Clinical Medicine • Previous Articles     Next Articles

Clinical analysis and type distribution of human papilloma virus among gynecologic outpatients

LI Chen1, CHENG Yufeng1, LI Ailu2   

  1. 1. Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Obstetrics and Gynecology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, Fujian, China
  • Received:2015-03-23 Online:2015-11-10 Published:2015-11-10

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Abstract: Objective To explore the infection rate and characteristics of human papilloma virus (HPV) among gynecologic outpatients, distribution of HPV types, and the relationship between HPV and cervical neoplasms. Methods Flow-through hybridization and gene chip ttechnique was employed to detect HPV genotypes of 5 869 gynecologic outpatients. Results The total infection rate was 23.6%, the detection rate of HR-HPV and LR-HPV was 19.6% and 6.7%, respectively. The most common type of HPV was HPV16, followed by 52, 11, 58, 6, 18, 53 and 33. Of the 1,385 HPV cases, 72.1% acquired single subtype of HPV, 21.3% had two different subtypes, and 6.6% had more than three different subtypes. HPV infection rate in patients with cervical cancer (91.7%) was significantly higher than that in patients with cervicitis (χ2=207.426, P<0.001) and healthy controls (χ2=252.211, P<0.001). HPV16,18, 31, 33, 58 and 45 were most commonly found in patients with cervical cancer. HPV infection rate was significant (χ2=36.486, P<0.01) in different age groups, the highest (32.5%) was in women under 25 years old, followed by 28.4% in women above 50 years old. Conclusion Among gynecologic HPV outpatients, most were infected with HR-HPV, some with LR-HPV, and a few with both HR- HPV and LR-HPV or with multiple HPV. There were obviousregional differences and characteristics of HPV type distribution in different population groups. The highest rate of HPV infection was in patients with cervical cancer. HPV 16, 18, and other HR- HPV were found to be closely related with cervical lesions and cervical cancer. Women under 25 and above 50 years old were high-risk groups.

Key words: Cervical neoplasms, Viral infection, Human Papillioma Virus, Gene chips

CLC Number: 

  • R737.33
[1] Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015, 65(2): 87-108.
[2] Sukasem C, Pairoj W, Saekang N, et al. Molecular epidemiology of human papillomavirus genotype in women with high-grade squamous intraepithelial lesion and cervical cancer: will a quadrivalent vaccine be necessary in Thailand?[J]. J Med Virol, 2011, 83(1): 119-126.
[3] Li J, Xu H, Chen Y, et al. Laparoscopic nerve-sparing radical parametrectomy for occult early-stage invasive cervical cancer after simple hysterectomy[J]. Int J Gynecol Cancer, 2012, 22(8): 1383-1388.
[4] Marnitz S, Kohler C, Affonso RJ, et al. Validity of laparoscopic staging to avoid adjuvant chemoradiation following radical surgery in patients with early cervical cancer[J]. Oncology, 2012, 83(6): 346-353.
[5] Tergas AI, Fader AN. Laparoendoscopic single-site surgery (LESS) radical hysterectomy for the treatment of early stage cervical cancer[J]. Gynecol Oncol, 2013, 129(1): 241-243.
[6] Atilgan R, Celik A, Boztosun A, et al. Evaluation of cervical cytological abnormalities in turkish population[J]. Indian J Pathol Microbiol, 2012, 55(1): 52-55.
[7] Guo YL, You K, Qiao J, et al. Natural history of infections with high-risk HPV in Chinese women with abnormal cervical cytology findings at baseline[J]. Int J Gynaecol Obstet, 2010, 110(2): 137-140.
[8] Arbyn M, Castellsague X, de Sanjose S, et al. Worldwide burden of cervical cancer in 2008[J]. Ann Oncol, 2011, 22(12): 2675-2686.
[9] Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer[J]. N Engl J Med, 2003, 348(6): 518-527.
[10] Chan PK, Chang AR, Cheung JL, et al. Determinants of cervical human papillomavirus infection: differences between high- and low-oncogenic risk types[J]. J Infect Dis, 2002, 185(1): 28-35.
[11] 张东红, 林美珊. 人乳头瘤病毒在国人宫颈病变中感染及型别分布特征的Meta分析[J]. 中国全科医学, 2010, 13(4): 1287-1290. ZHANG Donghong, LIN Meishan. Meta-analysis of human papillomavirus (HPV) prevalence and type distribution in cervical lesions in Chinese population[J]. Chinese General Practice, 2010, 13(4): 1287-1290.
[12] 陈红香. 新疆维吾尔族妇女人乳头瘤病毒测定与宫颈癌及癌前病变关系研究[J]. 中国医师杂志, 2010, 12(9): 1259-1260.
[13] Clifford GM, Smith JS, Plummer M, et al. Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis[J]. Br J Cancer, 2003, 88(1): 63-73.
[14] Clavel C, Masure M, Bory JP, et al. Hybrid capture II-based human papillomavirus detection, a sensitive test to detect in routine high-grade cervical lesions: a preliminary study on 1518 women[J]. Br J Cancer, 1999, 80(9): 1306-1311.
[15] 杜辉, 吴瑞芳, 汤惠茹, 等. 深圳市成年女性生殖道高危型人乳头瘤病毒感染与宫颈癌患病调查[J]. 中华流行病学杂志, 2012, 33(8): 799-802 DU Hui, WU Ruifang, TANG Huiru, et al. Investigation on the prevalence of high risk human papillomavirus and cervical cancer among adult women, in Shenzhen[J]. Chinese Journal of Epidemiology, 2012, 33(8): 799-802.
[16] Lee SA, Kang D, Seo SS, et al. Multiple HPV infection in cervical cancer screened by HPVDNAChip[J]. Cancer Lett, 2003, 198(2): 187-192.
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