JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (7): 43-47.doi: 10.6040/j.issn.1671-7554.0.2014.964

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Expression and significance of Th22 and Th17 cells in the peripheral blood of cervical cancer

TIAN Xinli1, JIAO Jun1, ZHANG Teng1, MA Daoxin2, CUI Baoxia1   

  1. 1. Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Institute of Hemopathy, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-12-17 Revised:2015-03-11 Online:2015-07-10 Published:2015-07-10

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Abstract: Objective To determine the expressions of Th22 and Th17 cells in the peripheral blood of cervical cancer and their contribution in the occurrence and progression of cervical cancer. Methods Flow cytometry was used to determine the percentages of Th22 cells and Th17 cells in the peripheral blood of 34 cervical cancer (CC) patients, 21 cervical intraepithelial neoplasia (CIN) patients and 19 healthy controls. ELISA was adopted to examine the plasma level of interleukin-22(IL-22). Results The percentages of Th22 cells (all P<0.01) and Th17 cells (CIN:P<0.05; CC:P<0.01) in CIN and CC patients were significantly increased compared with those in controls. The percentage of Th22 cells in cervical cancer was higher than that in CIN patients (P<0.01). An positive correlation between Th22 cells and Th17 cells was found in CIN patients (r=0.41, P<0.05). Th22 cells showed a positive correlation with Th17 cells in CC patients (r=0.49, P<0.01). The level of IL-22 in plasma was significantly increased in CC patients compared with that in controls (P<0.05). Conclusion There is a high percentage of Th22 and Th17 cells in CC patients. Th22 and Th17 cells may jointly participate in the pathogenesis and progression of CC.

Key words: Cervical neoplasms, Cervical intraepithelial neoplasia, Th22 cells, Th17 cells, Interleukin-22

CLC Number: 

  • R737.33
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