JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (7): 43-47.doi: 10.6040/j.issn.1671-7554.0.2014.964

Previous Articles     Next Articles

Expression and significance of Th22 and Th17 cells in the peripheral blood of cervical cancer

TIAN Xinli1, JIAO Jun1, ZHANG Teng1, MA Daoxin2, CUI Baoxia1   

  1. 1. Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Institute of Hemopathy, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-12-17 Revised:2015-03-11 Online:2015-07-10 Published:2015-07-10

PDF (PC)

55

Abstract: Objective To determine the expressions of Th22 and Th17 cells in the peripheral blood of cervical cancer and their contribution in the occurrence and progression of cervical cancer. Methods Flow cytometry was used to determine the percentages of Th22 cells and Th17 cells in the peripheral blood of 34 cervical cancer (CC) patients, 21 cervical intraepithelial neoplasia (CIN) patients and 19 healthy controls. ELISA was adopted to examine the plasma level of interleukin-22(IL-22). Results The percentages of Th22 cells (all P<0.01) and Th17 cells (CIN:P<0.05; CC:P<0.01) in CIN and CC patients were significantly increased compared with those in controls. The percentage of Th22 cells in cervical cancer was higher than that in CIN patients (P<0.01). An positive correlation between Th22 cells and Th17 cells was found in CIN patients (r=0.41, P<0.05). Th22 cells showed a positive correlation with Th17 cells in CC patients (r=0.49, P<0.01). The level of IL-22 in plasma was significantly increased in CC patients compared with that in controls (P<0.05). Conclusion There is a high percentage of Th22 and Th17 cells in CC patients. Th22 and Th17 cells may jointly participate in the pathogenesis and progression of CC.

Key words: Cervical neoplasms, Cervical intraepithelial neoplasia, Th22 cells, Th17 cells, Interleukin-22

CLC Number: 

  • R737.33
[1] Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002[J]. CA Cancer J Clin, 2005, 55(2):74-108.
[2] Ledwaba T, Dlamini Z, Naicker S, et al. Molecular genetics of human cervical cancer:role of papillomavirus and the apoptotic cascade[J]. Biol Chem, 2004, 385(8):671-682.
[3] Sheu BC, Chang WC, Lin HH, et al. Immune concept of human papillomaviruses and related antigens in local cancer milieu of human cervical neoplasia[J]. J Obstet Gynaecol Res, 2007, 33(2):103-113.
[4] Hebner CM, Laimins LA. Humanpapilloma viruses:basic mechanisms of pathogenesis and oncogenicity[J]. Rev Med Virol, 2006, 16(2):83-97.
[5] Kagami S, Rizzo HL, Lee JJ, et al. Circulating Th17, Th22, and Th1 cells are increased in psoriasis[J]. J Invest Dermatol, 2010, 130(5):1373-1383.
[6] Peng D, Xu B, Wang Y, et al. A high frequency of circulating th22 and th17 cells in patients with new onset graves' disease[J]. PloS One, 2013, 8(7):e68446. doi:10.1371/journal.pone.0068446.
[7] Wolk K, Witte E, Witte K, et al. Biology of interleukin-22[J]. Semin Immunopathol, 2010, 32(1):17-31.
[8] Zhang Y, Ma D, Zhang Y, et al. The imbalance of Th17/Treg in patients with uterine cervical cancer[J]. Clin Chim Acta, 2011, 412(11-12):894-900.
[9] Hou F, Li Z, Ma D, et al. Distribution of Th17 cells and Foxp3-expressing T cells in tumor-infiltrating lymphocytes in patients with uterine cervical cancer[J]. Clin Chim Acta, 2012, 413(23-24):1848-1854.
[10] Ryan-Payseur B, Ali Z, Huang D, et al. Virus infection stages and distinct Th1 or Th17/Th22 T-cell responses in malaria/SHIV coinfection correlate with different outcomes of disease[J]. J Infect Dis, 2011, 204(9):1450-1462.
[11] Zhang L, Li YG, Li YH, et al. Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis[J]. PloS One, 2012, 7(4):e31000. doi:10.1371/journal.pone.0031000.
[12] Zhuang Y, Peng LS, Zhao YL, et al. Increased intratumoral IL-22-producing CD4(+) T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival[J]. Cancer Immunol Immunother, 2012, 61(11):1965-1975.
[13] Liu T, Peng L, Yu P, et al. Increased circulating Th22 cells and Th17 cells are associated with tumor progression and patients survival in human gastric cancer[J]. J Clin Immunol, 2012, 32(6):1332-1339.
[14] Qin S, Ma S, Huang X, et al. Th22 cells are associated with hepatocellular carcinoma development and progression[J]. Chin J Cancer Res, 2014, 26(2):135-141.
[15] Ye ZJ, Zhou Q, Yin W, et al. Interleukin 22-producing CD4+ T cells in malignant pleural[J]. Cancer Lett, 2012, 326(1):23-32.
[16] Duhen T, Geiger R, Jarrossay D, et al. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells[J].Nat Immunol, 2009, 10(8):857-863.
[17] 杨佩芳, 付婷, 张建新, 等. 宫颈癌患者外周血和癌组织中Th17细胞水平的变化及其临床意义[J]. 临床检验杂志, 2011, 29(8):586-588. YANG Peifang, FU Ting, ZHANG Jianxin, et al. Detection and significance of TH17 cell in peripheral blood mononuclear cells and cancerous tissue of patients with cervical cancer[J]. Chinese Journal of Clinical Laboratory Science, 2011, 29(8):586-588.
[18] Jiang R, Tan Z, Deng L, et al. Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3[J]. Hepatology, 2011, 54(3):900-909.
[1] LIU Jingkang, YANG Jianyong, MENG Lihua, JIANG Jie. The value of serum miR-17-92 cluster in early diagnosis of HPV-positive cervical cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 86-90.
[2] WANG Yafen, YANG Yongxia, LIU Ya, MA Demei, ZHU Lin. Use of Cervista HPV HR A9 group virus to identify patients with negative cytological but positive high-risk HPV [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 69-71.
[3] ZHANG Zhan, XU Xiangfeng, LIU Haidong, WANG Wei. Diagnostic value of MRI in the T-staging of cervical cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(5): 70-73.
[4] PENG Hui, HE Junmei, SU Xuelian. Expression of serum miR-375 and its clinical significance in the diagnosis and postoperative monitoring of cervical cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(3): 68-71.
[5] DONG Xiaojing, LI Jing, ZHAO Lei, QI Mei, SUN Zeyu, WANG Hong, ZHAO Weiming. Effect of natural killer cells on the production of interleukin-22 and disease process during Chlamydia muridarum lung infection [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 19-23.
[6] MAN Qi, ZHANG An, ZHANG Yuan, FAN Mingde, MA Daoxin, WANG Chengwei. Expressions and significance of Th17 and Th22 cells in peripheral blood of patients with glioma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(10): 55-59.
[7] BAI Jinxia, BAI Jinyun, SHI Xiuju, XU Hongwei. IL-22 protects mice from acute severe pancreatitis via STAT3 signaling pathway [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(6): 1-6.
[8] ZHANG Rongjun, HAN Bo, GAO Ling, ZHU Mei, DING Guoyu, LIANG Yan. Effects of CD40 knockdown by siRNA on rats with experimental autoimmune myocarditis and IL-22 expression [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 36-40.
[9] LI Chen, CHENG Yufeng, LI Ailu. Clinical analysis and type distribution of human papilloma virus among gynecologic outpatients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(11): 73-76.
[10] ZHANG Lu, YAN Lei, ZHANG Hui, ZHANG Xiaohui, LI Mingjiang, ZHAO Xingbo. Expression and clinical significance of sperm-associated antigen 9 in patients with cervical cancer and cervical intraepithelial neoplasia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(6): 67-71.
[11] SUN Gao-ying1, WANG Xiao-yuan2, ZHANG Xiao-jin1, HAO Xiu-yu1， GUO Yuan-fang1, WANG Xiao1, BI Wen-xiang1. Effects of N-acetylcysteine  on resistance to paclitaxel in cervical carcinoma cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(3): 42-47.
[12] FAN Heng-jian, ZHANG Yu-ke, XIAO Wei, ZHANG Yi, LI Hai-jun, WANG De-xiang. Changes of Treg and Th17 cells in the peripheral bloods of patients with
lung adenocarcinoma and their prognostic significance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(9): 73-78.
[13] LIU Xiang-lan, JIANG Yang, WANG Qun, ZHU Fa-liang, DONG Zhao-jing, GUO Chun, ZHANG Li-ning. The influence of PDCD4 gene to the differentiation of
T lymphocytes subsets [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(11): 6-.
[14] ZHANG Xing-liang1, XU Li2, WANG Zhi-ping1. Risk factors of cervical cancer： A meta-analysis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(1): 155-160.
[15] CHEN Xuan, WANG Yu. Alteration of Th17 cells in the peripheral blood of patients with Vogt-koyanagi-Harada disease and its significance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(9): 153-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd