JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (7): 39-42.doi: 10.6040/j.issn.1671-7554.0.2015.069

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Expression of netrin-1 in invasive ductal breast cancer and its relationship with tumor metastasis

GAO Yongsheng1, WANG Chunjian2, CAI Shuping1, SUN Jujie1, ZHANG Dexian1, SUN Yanlin3, MU Dianbin1   

  1. 1. Department of Pathology, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong, China;
    2. Department of Breast Surgery, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong, China;
    3. Department of Pathology, Medical College of Shandong University, Jinan 250012, Shandong, China
  • Received:2015-01-16 Revised:2015-05-19 Online:2015-07-10 Published:2015-07-10

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Abstract: Objective To investigate the expression of netrin-1 in invasive ductal breast cancer and its clinical significance. Methods The expression of netrin-1 in 46 cases of invasive ductal breast cancer was detected with immunohistochemical SP method. Results Of all 46 cases, 30 cases had positive and 16 cases had negative expression of netrin-1. The positive rate of netrin-1 expression was 78.6% (11/14) in the group of breast cancer with lymph node metastasis. The expression of netrin-1 was not related to the patients' age, tumor size, clinical stage, expression of ER, PR, Her-2 and KI-67 (P>0.05), but was closely related to tumor metastasis (P<0.05). Conclusion Netrin-1 is abnormally expressed in breast cancer. It probably plays an important role in tumorigenesis and metastasis of breast cancer, and may be used as a marker for the prediction of breast cancer metastasis.

Key words: Breast neoplasm, Axillary lymph node, Netrin-1 protein, Metastasis

CLC Number: 

  • R736.1
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