JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (6): 13-17.doi: 10.6040/j.issn.1671-7554.0.2014.515

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Assessment of abdominal lymph node metastasis of VX2 hepatic cancer rabbits with percutaneous transhepatic lymphosonography

LI Xuefeng1, WANG Shuanglong1, YU Mei2, CUI Hong3, SUN Yuanyuan4, DONG Lei4   

  1. 1. Department of Ultrasound, First People's Hospital of Jining City, Jining 272100, Shandong, China;
    2. Department of Ultrasound, Hospital for Infectious Diseases of Jining City, Jining 272031, Shandong, China;
    3. Special Clinical Laboratory, Central Hospital of Taian City, Taian 271000, Shandong, China;
    4. Department of Ultrasound, General Hospital of Jinan Military Command, Jinan 250031, Shandong, China
  • Received:2014-08-06 Revised:2015-03-19 Online:2015-06-10 Published:2015-06-10

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Abstract: Objective To investigate the applications of percutaneous transhepatic lymphosonography in assessing abdominal lymph node metastasis of VX2 hepatic cancer rabbits. Methods A total of 30 rabbits with VX2 tumor were divided into sham group (group A, n=5) and hepatic cancer group (group B, n=25). SonoVue was injected into the liver parenchyma inside and around the VX2 cancer to observe the normal heptic tissues, cancerous tissues and pericancerous tissues dynamically. The changes were quantatively analyzed. Results Of the 25 rabbits in group B, 11 (group B2) had lymph node metastasis while 14 (group B1) had not. Percutaneous transhepatic lymphosonography showed the liver tissues could be divided into 4 phases, interstitial space, defusing, plateau and dissipating phase. SonoVue disappeared in cancerous tissues faster than in pericancerous tissues, in which SonoVue sustained for 20 minutes. There were significant differences among normal heptic tissues, cancerous tissues and pericancerous tissues in plateau intensity(PTI)(P<0.01), and PTI in cancerous tissues was the greatest, followed by pericancerous tissues and normal heptic tissues. There were significant differences in pericancerous tissues of group A, B1 and B2, and PTI in group B2 was the greatest, followed by group B1 and group A (P<0.05). Conclusion Percutaneous transhepatic lymphosonography can provide detailed information of abdominal lymph node metastasis of hepatic cancer, which is useful for the choice of treatment and prediction of therapeutic effects.

Key words: Percutaneous transhepatic lymphosonography, Lymph node metastasis, Hepatic cancer

CLC Number: 

  • R445.1
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