JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (5): 108-111.doi: 10.6040/j.issn.1671-7554.0.2016.1435

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Tumor-induced osteomalacia: a report of 3 cases and review of literature

JIANG Jie, ZHANG Xiaoli, DONG Ming, LIU Jinbo, JIANG Ling   

  1. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2016-11-03 Online:2017-05-10 Published:2017-05-10

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Abstract: Objective To explore tumor-induced osteomalacia(TIO)and review relevant literature. Methods The clinical information of 3 TIO cases treated in our hospital in Feb. 2016 were retrospectively analyzed and relevant literatures were retrieved. Result All 3 cases manifested progressive ostalgia and myalgia. The laboratory readings indicated hypophosphatemia, hyperphosphaturia and elevated alkaline phosphatase. Imaging examinations showed osteomalacia. Masses on the body surface were observed in 2 cases, and a mass on the gum was detected in 1 case. All masses were removed, and the postoperative pathological results were phosphaturic mesenchymal tumor. The follow-up showed improvements of biochemical indexes and clinical symptoms. Conclusion TIO is a rare paraneoplastic syndrome. As tumors usually grow slowly and are not easy to be observed, they are likely to be misdiagnosed or underdiagnosed. However, resection of tumors shows good prognosis. Therefore, it is very important to find the tumors promptly.

Key words: Tumor-induced osteomalacia, Hypophosphatemia, Hyperphosphaturia, Operation

CLC Number: 

  • R589
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