Table of Content

  

30 December 2014
Volume 52 Issue S1

The expression of spinal Reelin following chronic constriction injury of the sciatic nerve in rats

YANG Qiao-yun, LI jin-jin, LI Huan-yan, WANG Bo, PENG Liang-yu, KUANG Xin

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  3-7. 

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Objective To detect the expression of Reelin in the lumbar spinal cord of a rat model of neuropathic pain induced by chronic constriction injury on sciatic never (CCI). Methods 54 male SD rats were randomly divided into sham operation group (Sham group, n=12) and CCI model group (CCI group, n=42). Paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) were tested on day 1 before operation and day 1, 4, 7, 10, 14, 17, 21 and 28 after operation. Western blot and RT-PCR were used to detect the protein and mRNA level of Reelin in rat spinal dorsal horn. Results Both PWMT and PWTL have no difference in rats between sham group and CCI group before operation. After sciatic never ligation, both PWMT and PWTL were significantly decreased(P<0.01)while sham operation have no effects on PWMT and PWTL (P>0.05). Compared with sham group, the expression of Reelin mRNA Were significantly decreased in CCI rats(P<0.05),so were the expression of Reelin protein(P<0.05). Conclusion Reelin was decreased in CCI rat spinal dorsal horn.

The study on association of TNF-α-238G/A gene polymorphisms in patients with oral lichen planus

YANG Yong-rong, LI Jun, LIANG Ye, LI Jin-du, LAN Jia-fu, LI Tian-zi

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  10-11. 

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Objective To explore the correlation between single nucleotide polymorphisms(SNPS) of tumor necrosis factor alpha-238-G/A (TNF-α-238-G/A) and the oral lichen planus(OLP). Methods A total of 112 cases of TNF α-238G/A gene SNPS from OLP patients(OLP group), as well as 110 cases from normal participants (control group), was screened by PCR-RELP. Results Phenotype frequency of TNF alpha-238-G/G, G/A and A/A in OLP group were 0.830, 0.152 and 0.018, respectively; and were 0.964, 0.038 and 0.000 in control group. Allele frequency of TNF alpha-238 G and TNF alpha-238-a in OLP group were 0.906 and 0.094 respectively, and were 0.982 and 0.018 in control group. There were significant differences in frequency of TNF-α-238-G/A between two groups (P<0.01). Conclusion TNF-α-238-G/A polymorphism is potentially correlated with OLP.

Effects of Chaipu decoction on expression of VEGF and TGF-β1on airway remodeling in asthmatic rats

HUANG Yan, KUANG Xin, Xiong Hua, LIU Xin, LUO Xiao-qin, LIU Bin

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  14-17. 

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Objective To investigate the machnism of Chaipu decoction in treatment of asthma and its effects on expression of vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1). Methods Forty SD rats randomly divided into four groups: the control group (group A), the dexamethasone group (group B), the ChaiPu decoction group (group C), the asthma chronic model group (group D). Airway remodeling was observed by H&E staining. Expression of VEGF, TGF-β1 mRNA and protein were measured by RT-PCR and immune histochemical method, respectively. Results Inflammatory cell infiltration, angiogenesis, thickening of the epithelial basement membrane and bronchial wall and bronchial narrowing were observed in D model group. The results of RT-PCR semi-quantitative analysis showed that gray value of VEGF, TGF-β1 of group D were significantly higher than other groups(P<0.05). The observed value of integral optical density (IOD) of VEGF, TGF-β1 were highest in group D (P<0.01) and lowest in group A (P<0.05 or P<0.01). Conclusion The increased expression of VEGF and TGF-β1 in asthmatic rats suggest that VEGF and TGF-β1 may be involved in airway modulating. Early use of Chaipu decoction in the treatment of asthma may down-regulate VEGF, TGF-β1 expression, therefore inhibit airway remodeling.

Correlation between sensibility, and side effects of 5-FU and DPYD gene polymorphisms in periphrel blood of patients with colon cancer

WANG Yao, CHEN Yan-hong, CHEN Hong

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  18-21. 

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Objective To explore the association of 5-FU susceptibility and side effects with dihydropyrimidine dehydrogenase (DPYD) gene polymorphism in colon cancer patients. Methods A total of 100 colon cancer patients were recruited and treated with FOLFOX4 regimen. Quantitative PCR were taken to measure DPYD gene polymorphism at loci 14G1A, A1627G, T85C3. Relationship between susceptibility and side effects of 5-FU and gene polymorphism were analyzed .Results 14G1A A1627G, T85C were detected with site mutation, with 14% , 11% and 17% of mutant frequencies , respectively .The susceptibility to 5-FU in mutant gene were significantly lower than those in wild-type gene (P<0.05). Adverse reaction rate such as bone marrow inhibition, hand-foot syndrome, diarrhea, gastrointestinal reactions was significantly higher in mutant gene than that of wild-type genes (P<0.05). Conclusion DPYD gene polymorphism may be useful in predicting side reaction of 5-FU.

Application of reconstructive fixation with plastic splint in treatment of supracondylar fracture of humerus in children

CHU Hai-kun, SHEN Jian-hui, XU Ya-jun, DIAO Zhen-bin, WANG Nuan-feng, LI Mei4, FANG Jin-nv

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  28-29. 

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Objective To Observe the effects of reconstructive plastic splint fixation in treatment of supracondylar fracture of humerus in children. Methods A total of 70 patients were randomly divided into treatment group (n=35) and control group (n=35), with treatment of reconstructive plastic splint fixation and crossed-pin interior fixation, respectively. Clinical effects were observed 4 weeks after, and incidence of cubitus varus was recorded during 1 year follow-up. Results Recovery rate was 94.28% in treatment group and 77.14% in control group, with a significant difference (P<0.05). Incidence of cubitus varus was 22.86% in treatment group and 42.85% in control group. Conclusion Reconstructive plastic splint fixation is effective in the treatment of supracondylar fracture of humerus in children.

Clinical observation of integrated traditional and western medicine in treatment of senile vaginitis

DAI Hong, WANG Hong-li

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  30-31. 

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Objective To observe the clinical effects of integrated traditional Chinese and western medicine treatment for senile vaginitis. Methods A total of 84 patients with senile vaginitis were given peroral treatment and external cleaning of Chinese traditional medicine, and external treatment of 0.5 g premarin ointment and endovaginal administration of metronidazole suppositories were given to those patients without liver dysfunction. Results Out of 84 patients, fully recovery in 68 cases, partial recovery in 13 cases recovered and no efficacy in 3 cases. Conclusion The combination of Chinese and western medicine treatment is effective in controlling symptoms and consolidating curative effect in the treatment of senile vaginitis.

Combination treatment of bisoprolol fumarate capsules and musa wilsonii in treatment of lacunar cerebral infarction

HE Si-lu, LU Gao-xiang, LIANG Ye, WEI Tong-yan, LI Qing-feng, LI Tian-zi, LAI Teng-fang, TANG Xi-qiang, Li Jin-du

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  40-42. 

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Objective To observed the clinical effects of bisoprolol fumarate capsules combined with musa wilsonii in treatment of lacunar cerebral infarction(LI). Methods A total of 120 elderly patients with LI were randomly divided into treatment group(n=60) and control group(n=60)。Another 30 normal people were recruited as healthy control group. Conventional antihypertensive therapy including bisoprolol fumarate capsules were performed in both groups, and extra musa wilsonii was administrated in treatment group. Comparison was made in symptomatic remission、fibrinolysis and vascular endothelial function between two groups.Results the recovery rate was 96.7% in treatment group and 95.0% in control group (P>0.05). Levels of tPA, PAI, ET, NO and PGI₂ in patients with LI were significant different from those in healthy controls(P<0.01). After treatment, levels of all indicators in treatment group returned to normal. but levels of tPA and PAI, ET and PGI₂ in control group were still different from thiose in healthy controls (P<0.01). Conclusion Bisoprolol fumarate capsules combined with musa wilsonii is effective in reparing fibrinolytic system and vascular endothelial damage.

Application of strap-uterine suture in caesarean postpartum hemorrhage

HUANG An-cui, TIAN Wei-yun

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  43-44. 

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Objective To investigate the application of strap-uterine suture in preventing caesarean postpartum hemorrhage. Methods Sixty four patients with caesarean postpartum hemorrhage were divided into observation group (n=32, with strap-uterine suture) and control group (n=32, with Intrauterine gauze packing). Operation time, amount of bleeding within 2 h and 24 h after operation were compared between two groups. Results Operation time, amount of bleeding 2 h and 24 h after operation in obsercation group were significantly lower than those in control group (P<0.05). Conclusion Comparied with intrauterine gauze packing, strap-uterine suture is more effective in preventing caesarean postpartum hemorrhage.

Use of raltitrexed combined with oxaliplatin or irinotecan as second-line chemotherapy for advanced colorectal cancer

LI Jian-ping, MIAO Yu-feng, CHEN Ping, CHEN Su-rong, LIU Hongqi

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  49-50. 

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Objective To observer the clinical effects of raltitrexed combined with oxaliplatin or irinotecan as second-line chemotherapy for advanced colorectal cancer. Methods Out of twenty five patients enrolled, seventeen patients received raltitrexed 3 mg/m² as a 15-min infusion, followed by oxaliplatin 130 mg/m² as a 2-hour infusion, and nine patients received raltitrexed 2.6 mg/m² as a 15-min infusion, followed by irinotecan 300 mg/m² as a 90-min infusion. Results The overall response rate of raltitrexed combined with oxaliplatin or irinotecan was 24%(6/25), and disease control rate was 68%(17/25). The median time of progression-free survival was 5.3 months. The most common adverse reactions were leucopenia/neutropenia decline, fatigue, appetite decrease and hepatic disorders, with incidence rates of 64%, 52%, 56%, 48%, and 56%, respectively, which mainly be graded Ⅰ to Ⅱ. Conclusion Raltitrexed combined with oxaliplatin or irinotecan as second-line chemotherapy has a high efficacy with acceptable tolerability, therefore being worth recommending for advanced colorectal cancer.

Study on correlation between thickness of retinal nerve fiber layer and visual field defect in glaucoma patients

CAO Guo-fan, XUE Jin-song, YAO Jin, JIANG Qin

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  68-70. 

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Objective To investigate the correlation between the thickness of retinal nerve fiber layer(RNFL) and corresponding visual field defect in glaucoma patients. Methods Forty angle-closure glaucoma patients were enrolled. Optical coherence tomography (OCT) was performed to obtain the thickness of RNFL in 6 positions of optic nerve head and the corresponding visual field sensitivity or visual field defect. Association was analyzed between thickness of temporal-superior RNFL and the visual field defect of nasal-inferior, between the thickness of temporal-inferior RNFL and the visual field defect of nasal-superior, between the thickness of mean RNFL and mean field defect. Results Linear correlation was found between the temporal-superior RNFL thickness and the nasal-inferior visual field defect (r=-0.83), between the temporal-inferior RNFL thickness and the nasal-superior visual field defect(r=-0.80). The negative correlation (r=-0.60) was found between the mean thickness of RNFL and the mean visual defect. Conclusion The thickness of RNFL can partly reflect the depth of the visual field defect.

Clinical effects of surgical therapy on peptic ulcer with perforation in elderly patients

LIU Shaoqun, Cao Yiou

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  71-72. 

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Objective To explore the effect of surgical therapy on peptic ulcer with perforation in elderly patients. Methods A total of 75 elderly patients with peptic ulcer combined perforation were divided into conservative treatment group (n=33) and surgical treatment group (n=42). The quality of ulcer healing, recurrence of perforation and complication were observed by follow up. Results Three cases was dead from multiple organ failure in surgical treatment. One case in conservation group transferred to surgical therapy as massive haemorrhage. The ulcer healing rate was 90.0% in surgical therapy group and 84.4% in conservation group, with no significant difference (P>0.05). There was no significant difference in incidence of perforation recurrence between two groups 1 and 2 years after (P>0.05), so were the incidence of gastrointestinal bleeding, pyloric obstruction cancerization (P>0.05). Conclusion The treatment for elderly patients with peptic ulcer and perforation should be selected properly.

Clinical observation of 39 cases of vocal cord polyp enucleation under the self-retaining laryngoscope

XIE Xiao-hong, CUI Yu-mei, DAI Da-chun

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  73-74. 

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Objective To observe the clinical value of vocal cord polyp enucleation under self-retaining laryngoscope. Methods A total of 39 patients with vocal cord polyp were received enucleation under self-retaining laryngoscope. Result There was no hyperemia or polyps in the vocal cords of 37 patients under the fiberoptic laryngoscope after a month. Mild hyperemia was observed in 2 patients. There was no case of recurrence during 6 month follow-up. Conclusion Vocal cord polyp enucleation under self-retaining laryngoscope is an effective and safe way of operation.

Correlations between serum levels of TP and clinical outcome in patients with advanced gastric cancer receiving S-1 regimen chemotherapy

XU Guang-hui, LI Yu, LIU Zhong-lun, HU Nan

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  77-79. 

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Objective To investigate the correlations between serum levels of TP and clinical outcome in patients with advanced gastric cancer receiving S-1 regimen chemotherapy. Methods Serum samples before chemotherapy were collected from 46 patients receiving first-line S-1 regimen chemotherapy from Jun 2012 to Jan 2014, TP levels were analyzed using ELISA assay. Results TP expressions were significantly lower in patients with liver metastasis than those in patients without liver metastasis (P<0.01). There was no difference in clinical beneficial rate (CBR) between patients with high and low levels of TP. The median progression-free survival (PFS) in patients with high level of TP was longer than those with low level of TP (6.5 m vs 5.0 m,P=0.026 ). Conclusion In patients receiving first-line S-1 regimen chemotherapy, those with high level of TP may get better prognosis than those with low level of TP.

Clinical effective observation of 980/1 470 nm dual-wavelength laser transurethral prostatectomy in the treatment of benignprostatic hyperplasia

QIAO Yu-hua, ZUO Shu-sen, LI Do-shun, HAO Qiang

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  85-87. 

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Objective To investigate the clinical effect of 980/1 470 nm dual-wavelength laser transurethral prostatectomy in the treatment of benign prostatic hyperplasia (BHP). Methods A total of 210 patients with BHP were treated with 980/1 470nm dual-wavelength laser transurethral prostatectomy. Operations were observed and the patients were followed up for 1 to 12 months. Maximum flow rate, bladder urine residue, International Prostate Symptom Score(IPSS) and the life quality score were detected preoperatively and at the end of 1 month, 3 months, 6 months, 12 months postoperatively. Results Mean operation time was (58.12±21.25) min. Laser irradiation time was (25.80±8.96) min, and mean bleeding volume was (45.22±17.13) mL during operation. No case received blood transfusion or suprapubic puncture cystostomy. the mean time of postoperative indwelling catheter after operation was (48.82±17.04) h. The mean hospital stay was (3.01±1.72) d. arduous, frequent and urgent micturition were relieved gradually 1 month after operation. Maximum flow rate, bladder urine residue, International Prostate Symptom Score(IPSS) and life quality score at the end of 1, 3, 6 and 12 months after operation were better than before (P<0.01). Conclusion 980/1 470 nm dual-wavelength laser transurethral prostatectomy, which has the advantages of high safety, little damage, few complications, etc, is worth promoting the use in clinic .

Clinical efficacy comparison of two different bone graft ways on diaphyseal bone nonunion

SHEN Jian-hui, CHU Hai-kun, LI Gang, SONG Yin-dong, XU Ya-jun, SHI Feng-jun, QU Cheng-bo

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  88-89. 

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Objective To observe the clinical effects of ring bone graft therapy of diaphyseal bone ununion. Methods A total of 30 patients with nonunion in long bone were randomly divided into observation (n=15) and control group (n=15) by registration order. Observation group was treated with iliac bone graft. Contral group was treated with ring bone graft. Length of stay was observed. In 6 months after discharge, comparison and evalution of bone healing and limb function between two groups were conducted according to Disability of Arm Shoulder and Hand (DASH) score and American knee society (ASK) knee index. Results Patients in observation group achieved shorter average hospitalization time, lower DASH score (P<0.05,P<0.01), and higher ASK knee index (P<0.01), compared to control group. Conclusion The effectiveness of ring bone graft therapy for diaphyseal bone ununion precedes traditional autogenous bone graft. Ring bone graft is an ideal way of treating bone ununion.

Clinical analysis of 86 cases with perforating injuries of eyeball in children

TAO Dan, XU Jiang-tao, XIAO Yi-shuang

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  90-91. 

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Objective To analyze the causes and complications of 86 cases with perforating injuries of eyeball in children. Methods Various clinical parameters were analyzed on 86 children with perforating injuries of eyeball who were treated in Kunming Children's Hospital from September 2012 to April 2014. A statistical analysis was performed on the injury-causing instruments, children's age distribution, postoperative complications , etc. Results Perforating wounds of the eye in children are more frequently observed at the age of 3 to 6 and that accounts for 47.67% of all cases. Sharp metal is the main injury-causing instrument of perforating wounds of the eye in children, accounting for 46.51%. Tramatic cataract (45.35%) and discoria (33.72%) are the main complications of perforating wounds of the eye in children. Conclusion Due to the particularity of age of onset, complexity of pathogenetic condition and severity of vsual impairment, doctors, parents and the society should attach importantance to the perforating wounds of the eye in children. Prevention is better than cure.

Application of plasmakinetic resection of the prostate for patients with benign prostate hyperplasia

TIAN Wei-yun, HUANG An-cui

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  92-93. 

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Objective To observe the application of plasmakinetic resection of the prostate (PKRP) for patients with benign prostate hyperplasia. Methods Out of 98 patients with prostatic hyperplasia, 49 patients with prostate volume ranged from 80～120 mL were set as control group, and 49 patients with prostate volume less than 80 mL were set as observation group. Operation duration, intraoperative blood loss, indwelling catheter time, bladder washing time, hospital stay and complications were compared between two groups. Results There were significant differences in operation duration and resection quality between two groups(P<0.05). There was no complication observed in either of two groups. Conclusion The effects of plasmakinetic resection of the prostate are similar among patients with different volume of prostatic hyperplasia.

Study on phacoemulsification combined with goniosynechialysis for lens-sourced glaucoma with cataract

WANG Guo-qiang, ZHAO Yan-tao, DING Ying, ZHAO Yan

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  98-99. 

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Objective To observe the effect of phacoemulsification combined with goniosynechialysis in treatment of lens-sourced glaucoma with cataract. Methods A total of 108 eyes were treated with phacoemulsification combined with goniosynechialysis. The main outcome measures were pre-operative and post-operative changes of intraocular pressure, visual acuity, range of adhersion and complications. Results The intraocular pressure of 108 eyes were reduced significantly after operation (P<0.01). After six month follow-up, the visual acuity and adhesion were improved (P<0.01). Conclusion It is effective and safe to use phacoemulsification combined with goniosynechialysis therapy for lens-sourced glaucoma with cataract.

Investigation on elderly empty-nesters with chronic disease in rural areas of Qiannan Guizhou province

LIN Xian-yan, YANG Sheng-wen, WEI Ya-li, WEI Xue-tuan, MO Xiao-gang, YANG Xiang-xiu

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  116-118. 

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Objective To investigate the epidemic data of elderly empty-nesters with chronic diseases three rural areas of Qiannan in Guizhou province. Methods By adopting the cluster sampling,empty-nesters aged over 60 years old from 8 villages were selected as research subjects. Their epidemic data on chronic diseases were collected and analyzed. Results The prevalence of chronic diseases was71.3% in 485 elderly empty-nesters, and the prevalence was 72.2% in male and 70.7% in female. The prevalence was 70.7%、80.0% and 61.9% in Maonan, Shui and Buyi ethic groups respectively, with a significant difference (P<0.01). Hypertension, osteoarthrosis, lumbar diseases, eye diseases and digestive system disease were five most common chronic diseases reported in research subjects, and there was significant difference in prevalence of osteoarthrosis and lumbar diseases between difference ethic groups (P<0.05). The distribution of chronic diseases in ethic groups with different age, monthly costs or number of children has significant differences(P<0.01). Conclusions The chronic disease is one of the major diseases that can affect the health of elderly population in rural areas. Raising the awareness of prevention and interventions on risk factors of diseases are useful ways to improve the quality of life among elderly population.

Observation on the curative effect of Levofloxacin hydrochloride on bacterial conjunctivitis

ZHU Jian-feng

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2014, 52(S1):  135-135. 

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Objective To observe the curative effect of Levofloxacin hydrochloride on bacterial conjunctivitis. Methods A total of 200 patients with bacterial conjunctivitis were selected and treated with Levofloxacin Hydrochloride Eye Drops, and the curative effect was observed. Results In 200 patients, 98 cases were cured, 36 markedly effective, 19 effective, 47 inefficient, and the total effective rate was 76.5%. Conclusion The curative effect of Levofloxacin hydrochloride on bacterial conjunctivitis is good with rare adverse reactions, and the clinical use of this therapy is worth being popularized.