JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (S1): 77-79.

Previous Articles     Next Articles

Correlations between serum levels of TP and clinical outcome in patients with advanced gastric cancer receiving S-1 regimen chemotherapy

XU Guang-hui1, LI Yu1, LIU Zhong-lun2, HU Nan1   

  1. 1. Department of Oncological Chemotherapy, The First People's Hospital of Lianyungang , Lianyungang 222002, Jiangsu China;
    2. Department of Laboratory, The First People's Hospital of Lianyungang , Lianyungang 222002, Jiangsu China
  • Received:2014-11-30 Published:2014-12-30
  • Contact: 李玉, E-mail: ly651226@163.com E-mail:ly651226@163.com

Abstract: Objective To investigate the correlations between serum levels of TP and clinical outcome in patients with advanced gastric cancer receiving S-1 regimen chemotherapy. Methods Serum samples before chemotherapy were collected from 46 patients receiving first-line S-1 regimen chemotherapy from Jun 2012 to Jan 2014, TP levels were analyzed using ELISA assay. Results TP expressions were significantly lower in patients with liver metastasis than those in patients without liver metastasis (P<0.01). There was no difference in clinical beneficial rate (CBR) between patients with high and low levels of TP. The median progression-free survival (PFS) in patients with high level of TP was longer than those with low level of TP (6.5 m vs 5.0 m,P=0.026 ). Conclusion In patients receiving first-line S-1 regimen chemotherapy, those with high level of TP may get better prognosis than those with low level of TP.

Key words: Gastric cancer, Thymidine phosphorylase, S-1, Prognosis

CLC Number: 

  • R735
[1] 夏传生,李娜萍,李明显,等.胸苷磷酸化酶及血管内皮生长因子在胃腺癌组织中的表达及其临床意义[J].华中科技大学学报: 医学版,2011,40(3): 343-346.
[2] Hata K,Fujiwaki R,Nakayama K,et al.Expression of thymidine phosphorylase and vascular endothelial growth factor in epithelial ovarian cancer: correlation with angiogenesis and progression of the tumor [J].Anticancer Res,1999,20(5C): 3941-3949.
[3] Fujiwaki R,Hata K,Nakayama K,et al.Gene expression for dihydropyrimidine dehydrogenase and thymidine phosphorylase influences outcome in epithelial ovarian cancer[J].J Clin Oncol,2000,18(23): 3946-3951.
[4] Matsuura T,Kuratate I,Teramachi K,et al.Thymidine phosphorylase expression is associated with both increase of intratumoral microvessels and decrease of apoptosis in human colorectal carcinomas[J].Cancer Res,1999,59(19): 5037-5040.
[5] Takebayashi Y,Miyadera K,Akiyama S,et al.Expression of thymidine phosphorylase in human gastric carcinoma[J].Cancer Science,1996,87(3): 288-295.
[6] Fujioka S,Yoshida K,Yanagisawa S,et al.Angiogenesis in pancreatic carcinoma [J].Cancer,2001,92(7): 1788-1797.
[7] 何琼,高静,王婷婷,等.晚期胃癌患者血清 TS、TP 表达水平与氟尿嘧啶为基础的化疗疗效及预后的相关性[J].中国癌症杂志,2013,23(4): 292-297.
[8] Nishimura G,Terada I,Kobayashi T,et al.Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5'-deoxy-5-fluorouridine as adjuvant chemotherapy [J].Oncol Rep,2002,9(3): 479-482.
[9] Zhou J,Xiao Y S,Tang Z Y,et al.Transfection of thymidine phosphorylase cDNA to human hepatocellular carcinoma cells enhances sensitivity to fluoropyrimidine but augments endothelial cell migration [J].J Cancer Res Clin Oncol,2005,131(8): 547-551.
[1] YU Jia-Zhi, WANG Ke-Lai, ZHUANG Yan, ZHANG Lian-Hai. Expression of S-100 and C-kit in child primary obstructive megaureter [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 73-.
[2] LI Yinglin, SONG Daoqing, XU Zhonghua. Identification of FKBP11 expression in clear cell renal cell carcinoma using bioinformatics analysis [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 45-51.
[3] MENG Zhaotun, LI Qin, SUN Hui, WU Xinfang, SUN Wenkai, GAO Wei. Correlation between interleukin-18 single nucleotide polymorphism and susceptibility of laryngeal squamous cell carcinoma: a report of 73 cases [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 58-63.
[4] SHI Shuang, LI Juan, MI Qi, WANG Yunshan, DU Lutao, WANG Chuanxin. Construction and application of a miRNAs prognostic risk assessment model of gastric cancer [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 47-52.
[5] DI Xuemin, NIU Shulei, ZHAO Jing, DU Sui, YU Huimin, ZHANG Hongtao, WANG Juan. CT-guided 125I seed implantation for lymph node metastases in patients with gastric cancer of later stage [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(9): 79-84.
[6] LI Xingkai, LIU Zhanye, JIANG Yunfeng, LI Jun. Clinicopathological factors and prognosis between primary central and peripheral lung squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(9): 73-78.
[7] ZONG Shuai, XIAO Dongjie, LIU Hua, JIA Yanfei, MA Xiaoli, LI Huanjie, LI Ping, ZHENG Yan, WANG Yunshan. Expression of CSN5 and its correlation with the prognosis of gastric carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 12-16.
[8] SUN Qijing, CHEN Fangfang, LI Chunxiao, ZHANG Caiqing. Clinical value of PNI and HGB in evaluating the prognosis of the middle to late stage non-small cell lung cancer patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(4): 55-59.
[9] LIN Jiaxiang, GUO Zijia, SU Peng, WANG Xiao, GUO Yaxin, WU Xiaojuan, XIANG Lei, ZHOU Zhiqiang, WANG Yan, CUI Xiujie, PAN Aifeng, GUO Chenghao. The role of CIP2A in the transformation of breast ductal epithelium and prognosis of invasive breast cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 100-106.
[10] ZHOU Lanlan, PAN Xueyi, GUO Yu. Clinical characteristics and prognosis of 48 patients with mixed phenotype acute leukemia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 79-83.
[11] ZHANG Xiying, ZHAI Chunyan, LI Jingsong, HAN Bo. Expression of EZH2 in Chinese Ewing sarcoma patients and its relationship with clinicopathological parameters and prognosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 84-91.
[12] LIU Huiling, WANG Xingwen, FENG Shaobin, FENG Hong, HAN Junqing. Association between high expression of scavenger receptor class B type I and the prognosis of colon cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 84-89.
[13] LI Xiaoning, CUI Lianqun. Treatment timing of non-infarct-related artery in patients with multi-vessel disease and acute myocardial infarction [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 50-54.
[14] WANG Wen, LIU Yao, LONG Fei, MA Weixia, SU Lili. Correlation between lymphocyte-to-monocyte ratio in peripheral blood and prognosis of malignant pleural mesothelioma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 72-77.
[15] LIU Tong, ZHANG Xin, WANG Chuanxin. Significance of IRX5 mRNA in the diagnosis and prognosis of colorectal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(7): 69-74.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!