JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (S1): 68-70.

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Study on correlation between thickness of retinal nerve fiber layer and visual field defect in glaucoma patients

CAO Guo-fan, XUE Jin-song, YAO Jin, JIANG Qin   

  1. Department of Ophthalmology, Eye Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China
  • Received:2014-11-30 Published:2014-12-30

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Abstract: Objective To investigate the correlation between the thickness of retinal nerve fiber layer(RNFL) and corresponding visual field defect in glaucoma patients. Methods Forty angle-closure glaucoma patients were enrolled. Optical coherence tomography (OCT) was performed to obtain the thickness of RNFL in 6 positions of optic nerve head and the corresponding visual field sensitivity or visual field defect. Association was analyzed between thickness of temporal-superior RNFL and the visual field defect of nasal-inferior, between the thickness of temporal-inferior RNFL and the visual field defect of nasal-superior, between the thickness of mean RNFL and mean field defect. Results Linear correlation was found between the temporal-superior RNFL thickness and the nasal-inferior visual field defect (r=-0.83), between the temporal-inferior RNFL thickness and the nasal-superior visual field defect(r=-0.80). The negative correlation (r=-0.60) was found between the mean thickness of RNFL and the mean visual defect. Conclusion The thickness of RNFL can partly reflect the depth of the visual field defect.

Key words: OCT, RNFL, visual field defect

CLC Number: 

  • R775.2
[1] Gordon,MO,Beiser JA,Brandt JG,et al.The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma[J].Arch Ophthalmol,2002: 120(6): 714-720.
[2] Quigley HA,Dunkelberger GR,Green WR,et al.Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma[J].Am J Ophthalmol,1989,107(5): 453-464.
[3] 葛坚,赵家良,黎晓新.眼科学[M].北京:人民卫生出版社: 2010,244.
[4] Ferreras A,Pablo LE,Garway-Heath DF,et al.Mapping standard automated perimetry to the peripapillary retinal nerve fiber layer in glaucoma[J].Invest Ophthalmol Vis Sci,2008,49(7): 3018-3025.
[5] Medeiros FA,Alencar LM,Zangwill LM,Bowd C,Sample PA,Weinreb RN,et al.Prediction of functional loss in glaucoma from progressive optic disc damage[J].Arch Ophthalmol,2009,127(10): 1250-1256.
[6] Yalvac Ilgaz Sagdic,Altunsoy Muhsin ,Cansever Semra,et al.The Correlation Between Visual Field Defects and Focal Nerve Fiber Layer Thickness Measured With Optical Coherence Tomography in the Evaluation of Glaucoma[J].Journal of Glaucoma,2009,18(1): 53-61.
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