JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (12): 64-68.doi: 10.6040/j.issn.1671-7554.0.2014.406

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Correlation analysis of type 2 diabetes with diabetes family history and hypertension

LIU Li1, SHAO Yuhan2   

  1. 1. Department of Community Public Health, Qingdao Center for Disease Control and Prevention, Qingdao 266033, Shandong, China;
    2. Department of Biological Instrument, Qingdao Center for Disease Control and Prevention, Qingdao 266033, Shandong, China
  • Received:2014-06-18 Revised:2014-11-04 Published:2014-12-10

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Abstract: Objective To explore whether diabetes family history and hypertension have an interaction effect on the incidence of type 2 diabetes. Methods A total of 791 newly diagnosed patients with type 2 diabetes (T2DM) screened by our investigation were chosen as the case group, and 4 374 people with normal blood glucose in the same investigation were enrolled as the control group. The prevalence of diabetes family history and hypertension of the two groups were compared, and their correlation with T2DM was analyzed with an additive model. Results The prevalence of diabetes family history (χ2 = 40.1, P<0.001) and hypertension (χ2=145.4, P<0.001) of the case group were higher than those of the control group. After adjusting confounding factors by using a multiple Logistic regression model, the synergy index was 1.19, the relative excess risk due to interaction was 0.52, the attributable interaction percentage was 12.20%, and the pure attributable interaction percentage was 15.71%. Conclusion Diabetes family history and hypertension have a positive effect on the incidence of type 2 diabetes, and simultaneous existence of the two can lead to high risk of type 2 diabetes.

Key words: Hypertension, Type 2 diabetes, Correlation analysis, Diabetes family history, Interaction effect

CLC Number: 

  • R587.1
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