Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (5): 30-39.doi: 10.6040/j.issn.1671-7554.0.2021.0272

• Current Advance of Basic and Clinical Medical Virology • Previous Articles     Next Articles

Impact of EBV on the epigenetics of gastric carcinoma

Bing LUO*()   

  1. Department of Pathogen Biology, School of Basic Medical Sciences, Qingdao University, Qingdao 266071, Shandong, China
  • Received:2021-03-12 Online:2021-05-10 Published:2021-06-01
  • Contact: Bing LUO E-mail:qdluobing@163.com

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Abstract:

Epstein-Barr virus (EBV), an important human tumor virus, is closely related to the occurrence of a variety of tumors, including 10% gastric cancer. The role of EBV in gastric carcinogenesis has received increasing attention and EBV is considered to be another pathogenic factor in addition to Helicobacter pylori. In EBV-associated gastric carcinoma (EBVaGC), a typical characteristic is the extensive methylation of viral and host genomes, which expresses a limited number of viral genes including EBV nuclear antigen 1, EBV encoded small RNAs, Bam HI-A rightward transcripts, latent membrane protein 2A and miRNAs. Combined with other epigenetic mechanisms, EBV infection acts as an epigenetic driver of EBVaGC oncogenesis. This review will discuss the impact of EBV on the epigenetic alterations in EBVaGC and its role in oncogenesis.

Key words: DNA methylation, Epstein-Barr virus, Epigenetics, Gastric carcinoma, MicroRNA

CLC Number: 

  • R373.9
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