Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (8): 95-100.doi: 10.6040/j.issn.1671-7554.0.2020.0038

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Clinical observation of the effects of two endoscopic approaches on olfactory function in 232 patients undergoing pituitary tumor resection

WANG Hui, CHENG Lian, XU Shujun   

  1. Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Published:2020-08-07

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Abstract: Objective To compare the changes of olfactory function in two groups of patients who underwent endoscopic transsphenoidal approach(ETSA)and endoscopic nasal septum submucosal approach for pituitary adenoma resection. Methods A total of 232 patients with pituitary adenoma treated in our hospital during Jan. 2017 and Apr. 2018 were prospectively divided into the observation group(nasal septum submucosal approach, n=149)and control group(ETSA, n=83). Olfactory detection threshold(DT)and recognition threshold(RT)were measured at different time points before and after operation by five-taste method. Results Before operation, DT was 1.70±0.30 in the observation group and 1.67±0.36 in the control group, and RT was 2.22±0.52 and 2.26±0.50, respectively(P>0.05). One month after operation, DT rose to 3.22±0.99 and 3.56±0.91, respectively(P=0.011), and RT rose to 3.79±0.84 and 4.34±0.82(P<0.001). There were significant differences between the two groups(P<0.05), and the control group had higher DT and RT than the observation group. Three months after operation, DT was 2.69±0.70 in the observation group and 3.05±0.97 in the control group(P=0.003), and RT was 3.31±0.74 and 3.84±0.76, respectively(P<0.001). There were significant differences between the two groups(P<0.05). Six months after operation, DT was 2.21±0.64 in the observation group and 2.66±0.79 in the control group(P<0.001), and RT was 2.98±0.64 and 3.44±0.55, respectively(P<0.001). There were significant differences between the two groups(P<0.01), and the control group had higher DT and RT than the observation group. Conclusion Both approaches could affect the olfactory function, which could not return to the pre-operative level 6 months after operation. Compared with ETSA, the endoscopic nasal septum submucosal approach caused less damage to olfactory function.

Key words: Endoscopic nasal septum submucosal approach, Endoscopic transsphenoidal approach, Pituitary adenoma, Olfactory disfunction

CLC Number: 

  • R619
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