寨卡病毒感染与疾病

doi:10.6040/j.issn.1671-7554.0.2021.0332

Abstract

Abstract:

Zika virus (ZIKV) is an arthropod-borne virus in the family Flaviviridae, which is the pathogen of ZIKV disease (ZVD). First identified in 1947, ZIKV caused sporadic infections in human. However, since 2007, ZIKV infections have spread around the world and caused severe neurological complications such as microcephaly and Guillain-Barré syndrome (GBS). Notably, ZIKV can be sexually transmitted and affect male reproductive health. The World Health Organization declared in February 2016 ZIKV to be an international public health emergency. This paper provides a brief review to ZIKV epidemiology and ZVD complications.

Key words: Zika virus, ZIKV disease, Microcephaly, Guillain-Barré syndrome, Congenital Zika syndrome

CLC Number:

R373

Jing AN,Zhengran SONG,Zida ZHEN,Yanhua WU. Zika virus infection and disease[J].Journal of Shandong University (Health Sciences), 2021, 59(5): 22-29.

Figures/Tables 2

Fig.1

Table 1

References 67

1	Besnard M , Lastere S , Teissier A , et al. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014[J]. Euro Surveill, 2014, 19 (13): 20751.
2	Musso D , Nhan T , Robin E , et al. Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014[J]. Euro Surveill, 2014, 19 (14): 20761.
3	Duffy MR , Chen TH , Hancock WT , et al. Zika virus outbreak on Yap island, federated states of micronesia[J]. N Engl J Med, 2009, 360 (24): 2536- 2543. doi: 10.1056/NEJMoa0805715
4	Ioos S , Mallet HP , Leparc Goffart I , et al. Current Zika virus epidemiology and recent epidemics[J]. Med Mal Infect, 2014, 44 (7): 302- 327. doi: 10.1016/j.medmal.2014.04.008
5	França GV , Schuler-Faccini L , Oliveira WK , et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation[J]. Lancet, 2016, 388 (10047): 891- 897. doi: 10.1016/S0140-6736(16)30902-3
6	Bhardwaj S , Gokhale MD , Mourya DT . Zika virus: Current concerns in India[J]. Indian J Med Res, 2017, 146 (5): 572- 575.
7	Hu T , Li J , Carr MJ , et al. The Asian lineage of zika virus: transmission and evolution in Asia and the americas[J]. Virol Sin, 2019, 34 (1): 1- 8. doi: 10.1007/s12250-018-0078-2
8	Fu S , Song S , Liu H , et al. ZIKA virus isolated from mosquitoes: a field and laboratory investigation in China, 2016[J]. Sci China Life Sci, 2017, 60 (12): 1364- 1371. doi: 10.1007/s11427-017-9196-8
9	Brasil P , Calvet GA , Siqueira AM , et al. Zika virus outbreak in Rio de Janeiro, Brazil: clinical characterization, epidemiological and virological aspects[J]. PLoS Negl Trop Dis, 2016, 10 (4): e0004636. doi: 10.1371/journal.pntd.0004636
10	Brasil P , Pereira JP , Jr Moreira ME , et al. Zika virus infection in pregnant women in rio de janeiro[J]. N Engl J Med, 2016, 375 (24): 2321- 2334. doi: 10.1056/NEJMoa1602412
11	Miner JJ , Cao B , Govero J , et al. Zika virus infection during pregnancy in mice causes placental damage and fetal demise[J]. Cell, 2016, 165 (5): 1081- 1091. doi: 10.1016/j.cell.2016.05.008
12	Tabata T , Petitt M , Puerta-Guardo H , et al. Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission[J]. Cell Host Microbe, 2016, 20 (2): 155- 166. doi: 10.1016/j.chom.2016.07.002
13	Tang H , Hammack C , Ogden SC , et al. Zika virus infects human cortical neural progenitors and attenuates their growth[J]. Cell Stem Cell, 2016, 18 (5): 587- 590. doi: 10.1016/j.stem.2016.02.016
14	Li C , Xu D , Ye Q , et al. Zika virus disrupts neural progenitor development and leads to microcephaly in mice[J]. Cell Stem Cell, 2016, 19 (1): 120- 126. doi: 10.1016/j.stem.2016.04.017
15	Counotte MJ , Meili KW , Taghavi K , et al. Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review[J]. F1000Res, 2018, 15 (7): 196.
16	Rasmussen SA , Jamieson DJ , Honein MA , et al. Zika virus and birth defects--reviewing the evidence for causality[J]. N Engl J Med, 2016, 374 (20): 1981- 1987. doi: 10.1056/NEJMsr1604338
17	Barcellos C , Xavier DR , Pavão AL , et al. Increased hospitalizations for neuropathies as indicators of zika virus infection, according to health information system data, brazil[J]. Emerg Infect Dis, 2016, 22 (11): 1894- 1899. doi: 10.3201/eid2211.160901
18	Marinho F , Araujo VE , Porto DL , et al. Microcephaly in Brazil: prevalence and characterization of cases from the Information System on Live Births (Sinasc), 2000-2015[J]. Epidemiol Serv Saude, 2016, 25 (4): 701- 712. doi: 10.5123/S1679-49742016000400004
19	Brito CA , Cordeiro MT . One year after the Zika virus outbreak in Brazil: from hypotheses to evidence[J]. Rev Soc Bras Med Trop, 2016, 49 (5): 537- 543. doi: 10.1590/0037-8682-0328-2016
20	Gulland A . Zika virus is a global public health emergency, declares WHO[J]. BMJ Clin Res Ed, 2016, 352, i657. doi: 10.1136/bmj.i657
21	Kleber de Oliveira W , Cortez-Escalante J , De Oliveira WT , et al. Increase in Reported prevalence of microcephaly in infants born to women living in areas with confirmed zika virus transmission during the first trimester of pregnancy-Brazil, 2015[J]. MMWR Morb Mortal Wkly Rep, 2016, 65 (9): 242- 247. doi: 10.15585/mmwr.mm6509e2
22	Cauchemez S , Besnard M , Bompard P , et al. Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study[J]. Lancet, 2016, 387 (10033): 2125- 2132. doi: 10.1016/S0140-6736(16)00651-6
23	Yuan L , Huang XY , Liu ZY , et al. A single mutation in the prM protein of Zika virus contributes to fetal microcephaly[J]. Science, 2017, 358 (6365): 933- 936. doi: 10.1126/science.aam7120
24	Araujo AQ , Silva MT , Araujo AP . Zika virus-associated neurological disorders: a review[J]. Brain, 2016, 139 (Pt8): 2122- 2130.
25	De Fatima Vasco Aragao M , Van Der Linden V , Brainer-Lima AM , et al. Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study[J]. BMJ, 2016, 353, i3182. doi: 10.1136/bmj.i3182
26	van der Linden V , de Lima Petribu NC , Pessoa A , et al. Association of severe hydrocephalus with congenital zika syndrome[J]. JAMA Neurol, 2019, 76 (2): 203- 210. doi: 10.1001/jamaneurol.2018.3553
27	van der Linden H , Carvalho MD , van der Linden V , et al. Epilepsy profile in infants with congenital zika virus infection[J]. N Engl J Med, 2018, 379 (9): 891- 892. doi: 10.1056/NEJMc1716070
28	Nielsen-Saines K , Brasil P , Kerin T , et al. Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children[J]. Nat Med, 2019, 25 (8): 1213- 1217. doi: 10.1038/s41591-019-0496-1
29	Aragao MFVV , Brainer-Lima AM , Holanda AC , et al. Spectrum of spinal cord, spinal root, and brain mri abnormalities in congenital zika syndrome with and without arthrogryposis[J]. AJNR Am J Neuroradiol, 2017, 38 (5): 1045- 1053. doi: 10.3174/ajnr.A5125
30	van der Linden V , Filho EL , Lins OG , et al. Congenital Zika syndrome with arthrogryposis: retrospective case series study[J]. BMJ, 2016, 354, i3899. doi: 10.1136/bmj.i3899
31	Melo AS , Aguiar RS , Amorim MM , et al. Congenital zika virus infection: beyond neonatal microcephaly[J]. JAMA Neurol, 2016, 73 (12): 1407- 1416. doi: 10.1001/jamaneurol.2016.3720
32	Schuler-Faccini L , Ribeiro EM , Feitosa IM , et al. Possible association between zika virus infection and microcephaly-brazil, 2015[J]. MMWR Morb Mortal Wkly Rep, 2016, 65 (3): 59- 62. doi: 10.15585/mmwr.mm6503e2
33	De Paula Freitas B , De Oliveira Dias JR , Prazeres J , et al. Ocular findings in infants with microcephaly associated with presumed zika virus congenital infection in salvador, brazil[J]. JAMA Ophthalmol, 2016, 134 (5): 529- 535. doi: 10.1001/jamaophthalmol.2016.0267
34	Ventura CV , Maia M , Ventura BV , et al. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection[J]. Arq Bras Oftalmol, 2016, 79 (1): 1- 3.
35	Zin AA , Tsui I , Rossetto J , et al. Screening criteria for ophthalmic manifestations of congenital zika virus infection[J]. JAMA Pediatr, 2017, 171 (9): 847- 854. doi: 10.1001/jamapediatrics.2017.1474
36	Ventura LO , Ventura CV , Lawrence L , et al. Visual impairment in children with congenital Zika syndrome[J]. J AAPOS, 2017, 21 (4): 295- 299. doi: 10.1016/j.jaapos.2017.04.003
37	Freitas DA , Souza-Santos R , Carvalho LMA , et al. Congenital zika syndrome: a systematic review[J]. PLoS One, 2020, 15 (12): e0242367. doi: 10.1371/journal.pone.0242367
38	Ventura CV , Ventura LO , Bravo-Filho V , et al. Optical coherence tomography of retinal lesions in infants with congenital zika syndrome[J]. JAMA Ophthalmol, 2016, 134 (12): 1420- 1427. doi: 10.1001/jamaophthalmol.2016.4283
39	Parke DW , Almeida DR , Albini TA , et al. Serologically confirmed zika-related unilateral acute maculopathy in an adult[J]. Ophthalmology, 2016, 123 (11): 2432- 2433. doi: 10.1016/j.ophtha.2016.06.039
40	Ventura LO , Ventura CV , Dias NC , et al. Visual impairment evaluation in 119 children with congenital Zika syndrome[J]. J AAPOS, 2018, 22 (3): 218- 222. doi: 10.1016/j.jaapos.2018.01.009
41	Orofino DHG , Passos SRL , de Oliveira RVC , et al. Cardiac findings in infants with in utero exposure to Zika virus- a cross sectional study[J]. PLoS Negl Trop Dis, 2018, 12 (3): e0006362. doi: 10.1371/journal.pntd.0006362
42	Cavalcanti DD , Alves LV , Furtado GJ , et al. Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study[J]. PLoS One, 2017, 12 (4): e0175065. doi: 10.1371/journal.pone.0175065
43	Bai CZ , Li SH , Song S , et al. Zika virus induces myocardial immune response and myocarditis in mice[J]. J Mol Cell Cardiol, 2020, 148, 103- 105. doi: 10.1016/j.yjmcc.2020.08.014
44	Costa Monteiro LM , Cruz GNO , Fontes JM , et al. Neurogenic bladder in the settings of congenital Zika syndrome: a confirmed and unknown condition for urologists[J]. J Pediatr Urol, 2019, 15 (5): 450.
45	Besnard M , Eyrolle-Guignot D , Guillemette-Artur P , et al. Congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013 to 2014 Zika virus epidemic in French Polynesia[J]. Euro Surveill, 2016, 21 (13) doi: 10.2807/1560-7917.ES.2016.21.13.30181
46	Sarno M , Sacramento GA , Khouri R , et al. Zika virus infection and stillbirths: a case of hydrops fetalis, hydranencephaly and fetal demise[J]. PLoS Negl Trop Dis, 2016, 10 (2): e0004517. doi: 10.1371/journal.pntd.0004517
47	Watrin L , Ghawché F , Larre P , et al. Guillain-Barré Syndrome (42 Cases) occurring during a zika virus outbreak in french polynesia[J]. Medicine (Baltimore), 2016, 95 (14): e3257. doi: 10.1097/MD.0000000000003257
48	Musso D , Nilles EJ , Cao-Lormeau VM . Rapid spread of emerging Zika virus in the Pacific area[J]. Clin Microbiol Infect, 2014, 20 (10): 595- 596. doi: 10.1111/1469-0691.12707
49	Broutet N , Krauer F , Riesen M , et al. Zika virus as a cause of neurologic disorders[J]. N Engl J Med, 2016, 374 (16): 1506- 1509. doi: 10.1056/NEJMp1602708
50	Mier-Y-Teran-Romero L , Delorey MJ , Sejvar JJ , et al. Guillain-Barré syndrome risk among individuals infected with Zika virus: a multi-country assessment[J]. BMC Med, 2018, 16 (1): 67. doi: 10.1186/s12916-018-1052-4
51	Carteaux G , Maquart M , Bedet A , et al. Zika virus associated with meningoencephalitis[J]. N Engl J Med, 2016, 374 (16): 1595- 1596. doi: 10.1056/NEJMc1602964
52	Mécharles S , Herrmann C , Poullain P , et al. Acute myelitis due to Zika virus infection[J]. Lancet, 2016, 387 (10026): 1481. doi: 10.1016/S0140-6736(16)00644-9
53	Vieira MA , Aguiar Ade A , Borba Ade S , et al. West nile fever in Brazil: sporadic case, silent endemic disease or epidemic in its initial stages?[J]. Rev Inst Med Trop Sao Paulo, 2015, 57 (3): 276. doi: 10.1590/S0036-46652015000300017
54	Foy BD , Kobylinski KC , Chilson Foy JL , et al. Probable non-vector-borne transmission of Zika virus, Colorado, USA[J]. Emerg Infect Dis, 2011, 17 (5): 880- 882. doi: 10.3201/eid1705.101939
55	Moreira J , Peixoto TM , Siqueira AM , et al. Sexually acquired Zika virus: a systematic review[J]. Clin Microbiol Infect, 2017, 23 (5): 296- 305. doi: 10.1016/j.cmi.2016.12.027
56	Atkinson B , Thorburn F , Petridou C , et al. Presence and persistence of zika virus rna in semen, United Kingdom, 2016[J]. Emerg Infect Dis, 2017, 23 (4): 611- 615. doi: 10.3201/eid2304.161692
57	Musso D , Roche C , Robin E , et al. Potential sexual transmission of Zika virus[J]. Emerg Infect Dis, 2015, 21 (2): 359- 361. doi: 10.3201/eid2102.141363
58	Joguet G , Mansuy JM , Matusali G , et al. Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study[J]. Lancet Infect Dis, 2017, 17 (11): 1200- 1208. doi: 10.1016/S1473-3099(17)30444-9
59	Ma W , Li S , Ma S , et al. Zika virus causes testis damage and leads to male infertility in mice[J]. Cell, 2016, 167 (6): 1511- 1524. doi: 10.1016/j.cell.2016.11.016
60	杨威, 盛子洋, 吴艳花, 等. 寨卡病毒与男性(雄性)生殖健康[J]. 中国人兽共患病学报, 2019, 35 (6): 545- 551.
	YANG Wei , SHENG Ziyang , WU Yanhua , et al. Research progresses on the relationship between Zika virus and reproductive health of male[J]. Chinese Journal of Zoonoses, 2019, 35 (6): 545- 551.
61	Di Persio S , Saracino R , Fera S , et al. Spermatogonial kinetics in humans[J]. Development, 2017, 144 (19): 3430- 3439. doi: 10.1242/dev.150284
62	Vinhaes ES , Santos LA , Dias L , et al. Transient hearing loss in adults associated with zika virus infection[J]. Clin Infect Dis, 2017, 64 (5): 675- 677.
63	Schirmer PL , Wendelboe A , Lucero-Obusan CA , et al. Zika virus infection in the Veterans Health Administration (VHA), 2015-2016[J]. PLoS Negl Trop Dis, 2018, 12 (5): e0006416. doi: 10.1371/journal.pntd.0006416
64	Monsalve DM , Pacheco Y , Acosta-Ampudia Y , et al. Zika virus and autoimmunity. One-step forward[J]. Autoimmun Rev, 2017, 16 (2): 1237- 1245.
65	Wu Y , Cui X , Wu N , et al. A unique case of human Zika virus infection in association with severe liver injury and coagulation disorders[J]. Sci Rep, 2017, 7 (1): 11393. doi: 10.1038/s41598-017-11568-4
66	Pougnet L , Thill C , Pougnet R , et al. Zika virus infection[J]. Ann Biol Clin (Paris), 2016, 74 (6): 712- 716.
67	Mead PS , Duggal NK , Hook SA , et al. Zika virus shedding in semen of symptomatic infected men[J]. N Engl J Med, 2018, 378 (15): 1377- 1385. doi: 10.1056/NEJMoa1711038

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类型	症状
先天感染异常
不良妊娠	流产/死胎
	胎盘功能不全
先天发育不良	小头畸形
	胎儿发育迟缓
神经系统	皮质发育畸形/钙化
	后颅窝畸变
	脑容量减少
	脑室肥大
	脑积水
	癫痫患病率增加	癫痫痉挛
		局灶性运动性癫痫发作
		强直性癫痫发作
	语言、听力、视力、生长发育障碍
骨骼	多发性先天性关节炎
	关节畸形/软化/脱位
	运动发育受累	运动神经元明显少于预期水平
视觉	眼后节	斑块斑驳
		脉络膜视网膜萎缩
		视神经异常
		晶状体半脱位
		眼球瘤
	视网膜	视网膜外层和视网膜色素上皮细胞丢失
	双眼异常	斜视/散光
		远视/近视
心血管系统	心脏缺陷	卵圆孔未闭
消化系统	吞咽困难
	肠道改变
	肝钙化、肿大
泌尿生殖系统	膀胱过度活动症
	膀胱容量降低，膀胱充盈压升高
	肾发育不全
	隐睾/小阴茎
呼吸系统	胸水
	膈肌麻痹
其他	听力异常
	发育异常
	颅面部比例失调
	头皮皮肤多余
后天感染异常
神经系统	吉兰-巴雷综合征
	外周神经综合征
	急性脊髓炎
	脑膜/脑炎
男性生殖系统	血精/少精
	前列腺炎/阴囊炎
	睾丸、附睾炎症，严重可致永久性损伤
听力	听力缺失/下降
	耳鸣
其他	充血性心力衰竭
	血小板减少
	肝脏损伤

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Zika virus infection and disease

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