JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (7): 23-27.doi: 10.6040/j.issn.1671-7554.0.2015.746

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Anti-influenza virus activities of garlic oil in mice model in vivo

ZHENG Qianqian1, LIU Ti2, XIE Keqin3, LIN Yi2, LI Zhong2, WANG Xianjun2, BI Zhenqiang2, WEN Hongling3, SONG Yanyan3, ZHAO Li3   

  1. 1. Clinical Laboratory of Tanggu Center for Disease Control and Prevention, Tianjin 300450, China;
    2. Shandong Center for Disease Control and Prevention, Jinan 250014, Shandong, China;
    3. School of Public Health, Shandong University, Jinan 250012, Shandong, China
  • Received:2015-08-07 Online:2016-07-10 Published:2016-07-10

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Abstract: Objective To investigate the effect of garlic oil on anti-influenza virus in mice in vivo. Methods The mice were given low, medium and high doses of garlic oil［25、50、100 mg/(kg·d)］ through the mouths, and divived into low, medium and high dose of garlic oil groups,then the flu virus was vaccinated. Meanwhile, the blank, virus, solvent and positive drug control groups were set up. Active state, body weight, lung, mortality and average survival time of mice were observed. Results Compared with the virus control group, the mice in the low, medium and high dose of garlic oil groups and positive drug control group had better states, higher body weights, less lung indexes, more relieved lung lesions and lower death rates; compared with the solvent control group, the survival time extended in the low, medium and high dose of garlic oil groups and positive drug control group(P<0.05). Conclusion Garlic oil has the anti-influenza virus activities to some degree in mice model in vivo.

Key words: Influenza virus, In vivo, Mice model, Garlic oil

CLC Number: 

  • R373.1
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[2] LI Yang, YAN Jie, FU Qiang-qiang, ZHAO Sheng, ZHANG Cui-li, YU Li-hua, XIE Ke-qin. Preventive effect of garlic oil on cyclophosphamide-induced   leukopenia in tumor-bearing mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(12): 153-157.
[3] ZHANG Cui-li,XIE Ke-qin,ZHAO Xiu-lan,ZHU Zhen-ping,YU Li-ua,ZENG Tao. arlic oil can prevent the decrease of leucocyte induced by radiation in mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(8): 781-784.
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