Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (8): 88-94.doi: 10.6040/j.issn.1671-7554.0.2020.0604

• Special Topic on Brain Science and Brain Like Intelligence • Previous Articles     Next Articles

The new strategies of targeting SUMOylation in the treatment of glioma

Anjing CHEN1,2,*(),Xun ZHANG1,2   

  1. 1. Department of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan 250012, Shandong, China
    2. Shandong Key Laboratory of Brain Function Remodeling, Jinan 250012, Shandong, China
  • Received:2020-04-15 Online:2020-08-01 Published:2020-08-07
  • Contact: Anjing CHEN E-mail:chenaj@sdu.edu.cn

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Abstract:

Small ubiquitin-like modification (SUMOylation), a dynamic process of post-translational modification, involves a series of physiological changes within the cells. SUMOylation also plays an important role in the pathological progresses of a number of cancers including the fatal disease, glioma. In this essay, we reviewed the key aspects of SUMOylation in association with glioma from the literatures and highlighted that some potential targets were expected to be therapeutic strategies in the treatment of glioma.

Key words: Glioma, SUMOylation, Malignant progression, Targeted therapy

CLC Number: 

  • R456

Fig.1

SUMOylation of glioma participates in the regulation of multiple cellular processes and leads to malignant progression"

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