Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (8): 34-41.doi: 10.6040/j.issn.1671-7554.0.2020.0725

• Special Topic on Brain Science and Brain Like Intelligence • Previous Articles     Next Articles

Mitochondrial dysfunction and related brain diseases

Chuanzhu YAN*(),Wei WANG,Kunqian JI,Yuying ZHAO   

  1. Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Received:2020-05-01 Online:2020-08-07 Published:2020-08-07
  • Contact: Chuanzhu YAN E-mail:chuanzhuyan@163.com

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Abstract:

Mitochondria provides most of the energy for the body through oxidative phosphorylation (OXPHOS) and participates in various physiological and biochemical processes such as cell signal transduction, inflammatory response and apoptosis. Brain is very sensitive to energy change. Mitochondrial dysfunction is associated with various disorders including genetic and metabolic diseases, neurodegenerative diseases, psychological diseases and brain aging via multiple pathways. At present, there is no specific treatment plan for mitochondrial encephalopathy. Research on mitochondrial gene targeted therapy is expected to break through the treatment bottleneck of mitochondrial diseases and brings hope to patients

Key words: Mitochondrial encephalopathy, Neurodegeneration, Psychological diseases, Brain aging, Targeted therapy

CLC Number: 

  • R742
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