JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (10): 60-65.doi: 10.6040/j.issn.1671-7554.0.2015.615

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Changes of regional homogeneity in vision-related resting-state network of pituitary adenoma patients with visual damage

QIAN Haiyan, WANG Xingchao, LIU Pinan   

  1. Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
  • Received:2015-06-26 Online:2016-10-10 Published:2016-10-10

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Abstract: Objective To explore the neural plasticity of vision-related network in pituitary adenoma patients with visual damage. Methods A total of 25 pituitary adenoma patients with visual damage(PAPVD)and 25 age- and sex-matched corrected-normal-sighted healthy controls(HCs)were recruited and underwent a complete neuro-ophthalmologic evaluation as well as an MRI protocol, including structural and resting-state fMRI(RS-fMRI)sequences. Regional homogeneity(ReHo)of the vision-related resting-state network were evaluated. Two sample t-test was conducted to identify the changes between the two groups. Results Compared to HCs, PAPVDs showed a reduced ReHo in bilateral V1, V2, V3, lateral occipital complex(LOC), fusiform, MT+, thalamus, and an increased ReHo in precuneus gyrus, prefrontal cortex, posterior cingulate cortex(PCC), insular, supramarginal gyrus(SMG), and upplementary motor area(SMA). Conclusions Visual damage caused by pituitary adenoma can lead to decreased neural activity within the visual cortex, and increased neural activity beyond the visual cortex especially in core nodes of default mode network(DMN)and salience network(SN).

Key words: Resting-state fMRI, Visual damage, Default Network, Salience network, Neural plasticity

CLC Number: 

  • R739
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