JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (11): 32-37.doi: 10.6040/j.issn.1671-7554.0.2017.036

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Clinical significance of sodium fluorescein-guided resection of high-grade glioma under “yellow fluorescence” mode

WANG Chaochao, TIAN Hailong, JIANG Huifeng, GUO Wenqiang, WANG Zhigang   

  1. Department of Neurosurgery, Qilu Hospital of Shandong University(Qingdao), Qingdao 266000, Shandong, China
  • Received:2017-01-11 Online:2017-11-10 Published:2017-11-10

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Abstract: Objective To explore the clinical significance of sodium fluorescein-guided resection of high-grade glioma(HGG)under “yellow fluorescence” mode. Methods The clinical data of 21 HGG confirmed by pathological examination and treated during Jan. 2014 and Dec. 2015 were retrospectively analyzed. All patients underwent intravenous injection of sodium fluorescein after general anesthesia. Tumors were removed under “yellow fluorescence” mode. Fluorescence degree of different regions of tumor was compared and multiple site biopsy was implemented during the operation. Total resection rate was calculated and pathological results were analyzed after operation. All patients were followed up for a long term. Results “Yellow fluorescence” mode allowed a good discrimination between tumor and peripheral brain tissues. Total resection was achieved in 17 patients and subtotal resection in 4 patients. The core of tumor had a stronger fluorescence imaging compared to the boundary and the peritumoral edema(P<0.05). The pathological results differed in different regions of tumor in the same patient. Tumor cells could be detected in the peritumoral edema under traditional white light illumination. Conclusion Sodium fluorescein-guided surgery under “yellow fluorescence” mode helps to distinguish tumor and peripheral brain tissue as well as to facilitate total resection of gliomas. The fluorescence degree and pathological results differ in different regions of HGG.

Key words: Yellow fluorescence, Multiple site biopsy, Total resection, Sodium fluorescein, High-grade glioma

CLC Number: 

  • R651.1
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