Journal of Shandong University (Health Sciences)

Influence of inositol polyphosphate-4-phosphatase type II on the proliferation and apoptosis of cervical cancer cells

SUN Zeyu, CHEN Ying, LIN Jiaxiang, LIU Juan, ZHAO Weiming

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 1-6. doi:10.6040/j.issn.1671-7554.0.2016.1425

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Objective To study the effect of inositol polyphosphate-4-phosphatase type II(INPP4B)on the proliferation,cell cycle and apoptosis of cervical cancer cells. Methods Western blotting was employed to detect basic expression of INPP4B in various kinds of cervical cancer cell lines. The INPP4B expressions in LHCX-INPP4B transfected SiHa and C33a cells as well as INPP4B specific siRNA transfected CaSki cells were determined by Western blotting. CCK-8 and colony formation assay were used to test cell growth and proliferation. Cell cycle was detected by using BrdU assay. Cell apoptosis was evaluated using Annexin V-FITC/PI cell apoptosis kit. Results CCK-8 and clone formation assay showed that the overexpression of INPP4B significantly reduced the cell viability and clonogenic ability of SiHa and C33a(all P<0.05). BrdU assay showed that the proportion of SiHa and C33a cells in S phase decreased after being transfected with INPP4B(P=0.04, P=0.01). Accordantly, depletion of INPP4B in Caski cells increased cell viability and the percentage of the cells entering S phase(P<0.01). However, INPP4B did not influence the apoptosis of cervical cancer cells. Conclusion INPP4B inhibits the growth and proliferation of cervical cancer cells and leads to cell cycle arrest.

Effects of high exposure of endogenous reproductive hormones on perimenopausal and postmenopausal blood pressure in rats

JIA Jiajing, WANG Zhiping

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 7-14. doi:10.6040/j.issn.1671-7554.0.2017.219

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Objective To explore the effects of high-dose endogenous estrogen(17-β E₂)and progesterone(P)of the reproductive phase on the blood pressure of perimenopausal and postmenopausal rats and to observe the role of angiotensin II type-1 receptor(AT₁R). Methods Bilateral ovariectomy was performed during the diestrus phase of estrus cycle to induce rat models of artificial estrous cycle by 17-β E₂ and P. The models were divided into 3 groups: high-dose estrogen plus low-dose progesterone group(n=20, HELP), high-dose progesterone plus low-dose estrogen group(n=20, HPLE), and ovariectomized group(n=20, OVX). The experimental animals were given hormones for 8 weeks, decreasing dosages for 5 weeks and withdrawal hormones for 6 weeks to imitate the reproductive phase, perimenopausal phase and postmenopausal phase respectively. The changes of blood pressure, serum E₂ and P, and protein and mRNA expressions of AT₁R in the abdominal aorta were monitored. Results Compared with the OVX group, the HELP and HPLE groups had higher systolic blood pressure(SBP)in all phases(P<0.05); the HELP group had higher diastolic blood pressure(DBP)in the perimenopausal and postmenopausal phases(P<0.05), and higher protein and mRNA expressions of AT₁R in the reproductive and perimenopausal phases(P<0.05). The protein expression of AT₁R was positively correlated with serum concentration of E₂ and SBP(P<0.01). Conclusion Exposure to excessively high-dose 山东大学学报 (医学版)55卷11期 -贾佳静,等.育龄期高水平生殖激素对大鼠围绝经期及绝经后血压的影响 \=-endogenous estrogen in the reproductive phase raises the blood pressure in perimenopausal and postmenopausal rats. Elevated protein expression of AT₁R in the abdominal aorta is correlated with high SBP.

Urethral reconstruction with autologous tubular granulation tissues: functional and histological evaluation in male rabbits

JIANG Shiwei, YAN Lei, TANG Yueqing, REN Juchao, ZANG Yuanwei, ZHANG Yongzhen, GU Gangli, XU Zhonghua

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 15-21. doi:10.6040/j.issn.1671-7554.0.2017.144

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Objective To evaluate the feasibility by using autologous tubular granulation tissues for urethral reconstruction. Methods A total of 18 male rabbits were divided into the experimental group(n=9)and control group(n=9). A pendulous urethral segment of 1.0 cm was excised in all rabbits. In the experimental group, urethroplasty was performed with autologous tubular granulation tissues. In the control group, re-anastomosis was performed. Serial urethrography, general observation, histological detection and Western blotting were performed 1 month, 2 and 6 months after operation to dynamically evaluate patency degree and tissue regeneration. Results Histological and transmission electron microscopy of the autologous granulation tissues showed densely-arranged collagens and myofibroblasts. Urethrography showed the neo-urethra in the experimental group remained wide patent at each time point, while strictures developed in the control group. Histologically, layers of urothelium surrounded by increasingly organized smooth muscles were observed. Western blotting showed expressions of pan-cytokeratin AE1/AE3 and α-smooth muscle actin increased gradually with time, which reached similar level with normal urethra 6 months postoperatively. Conclusion Autologous tubular granulation tissues grown subcutaneously can be used to repair urethral defect of 1.0 cm in male rabbits.

Intermittent tensile stress affects the expression of TRPV5 in murine osteoclasts

PENG Fei, SONG Ling, QI Xiangmin, LI Yaqin, DIAO Yanfei, ZHAO Shoufeng, WANG Lili, YANG Fang, LU Shulai, LÜ Wenfang, GUO Dawei

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 22-26. doi:10.6040/j.issn.1671-7554.0.2017.099

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Objective To investigate the expression of transient receptor potential vanilloid receptor V(TRPV5)during the differentiation of osteoclasts mediated by intermittent tensile stress. Methods Murine osteoclasts were divided into 4 groups and mediated by different loading stress: group A(1 000 με), group B(3 000 με), group C(5 000 με), and group D(0 με). The mRNA expression of TRPV5 in the 4 groups was detected with fluorescence quantitative PCR before and after the differentiation. Results Compared with group D, the other 3 groups had higher mRNA expression of TRPV5(P<0.001). Pairwise comparison results showed that there was no statistical difference between group B and C(P>0.05),there was statistical difference between any other two groups(P<0.05). Conclusion Intermittent tensile stress promotes the expression of TRPV5 channel gene in osteoclasts within a certain range.

Isolation of Leptosphaerins H and I, two new xanthones from the endophytic fungus Leptosphaeria sp. and their anti-inflammatory activity

ZHANG Pengliang, ZHANG Longteng, LI Ailing, SHEN Tao, LOU Hongxiang, WANG Xiaoning

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 27-31. doi:10.6040/j.issn.1671-7554.0.2017.142

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Objective To study the metabolites from the strain of the fungus Leptosphaeria sp. L1201 which was isolated from healthy tissues of the plant Casearia balansae(Flacourtiaceae). Methods The compounds were isolated by different chromatographic methods, including silica gel and Sephadex LH-20 column chromatography as well as high performance liquid chromatography, and the structures of the compounds were determined on the basis of extensive spectroscopic techniques including HRMS, 1D and 2D NMR experiments and single-crystal X-ray diffraction analysis. Anti-inflammatory effects of isolated compounds were evaluated using nitric oxide(NO)inhibitory assay in murine RAW 264.7 macrophages. Results Two new xanthones were isolated from the EtOAc extract of the culture of the fungus Leptosphaeria sp. L1201 and their structures were identified as leptosphaerins H(1)and I(2). Compounds 1 and 2 inhibited the NO formation with IC₅₀ values being 126.7 and 72.6 μmol/L, respectively. Conclusion Leptosphaerins H and I are new xanthones, which show anti-inflammatory activity in RAW264.7 cells.

Clinical significance of sodium fluorescein-guided resection of high-grade glioma under “yellow fluorescence” mode

WANG Chaochao, TIAN Hailong, JIANG Huifeng, GUO Wenqiang, WANG Zhigang

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 32-37. doi:10.6040/j.issn.1671-7554.0.2017.036

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Objective To explore the clinical significance of sodium fluorescein-guided resection of high-grade glioma(HGG)under “yellow fluorescence” mode. Methods The clinical data of 21 HGG confirmed by pathological examination and treated during Jan. 2014 and Dec. 2015 were retrospectively analyzed. All patients underwent intravenous injection of sodium fluorescein after general anesthesia. Tumors were removed under “yellow fluorescence” mode. Fluorescence degree of different regions of tumor was compared and multiple site biopsy was implemented during the operation. Total resection rate was calculated and pathological results were analyzed after operation. All patients were followed up for a long term. Results “Yellow fluorescence” mode allowed a good discrimination between tumor and peripheral brain tissues. Total resection was achieved in 17 patients and subtotal resection in 4 patients. The core of tumor had a stronger fluorescence imaging compared to the boundary and the peritumoral edema(P<0.05). The pathological results differed in different regions of tumor in the same patient. Tumor cells could be detected in the peritumoral edema under traditional white light illumination. Conclusion Sodium fluorescein-guided surgery under “yellow fluorescence” mode helps to distinguish tumor and peripheral brain tissue as well as to facilitate total resection of gliomas. The fluorescence degree and pathological results differ in different regions of HGG.

A clinical analysis of transcranial Doppler in predicting delayed cerebral ischemia after ruptured aneurysm surgery

WANG Moulong, CHEN Yongkun, XING Deguang, QU Liangsuo, WANG Chengwei

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 38-41. doi:10.6040/j.issn.1671-7554.0.2017.223

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Objective To evaluate the sensibility of transcranial Doppler(TCD)in predicting delayed cerebral ischemia(DCI)after ruptured aneurysm surgery, and to explore the risk factors of DCI. Methods Clinical data of 67 patients with ruptured aneurysm who received intracranial aneurysmal clipped operation were retrospectively analyzed. Receiver operator characteristic curve(ROC)and Logistic regression were adopted to analyze the diagnostic accuracy and risk factors of DCI. Results DCI occurred in 18 of all patients, with an incidence rate of 26.9%. When the middle cerebral artery mean blood flow velocity(MCAVm)was 149.5 cm/s, TCD had the highest predicting accuracy, and the sensitivity and specificity were 88.9% and 81.6%, respectively. Modified Fisher grade and MCAVm≥130 cm/s were significantly correlated with the occurrence of DCI. Conclusion Early dynamic TCD monitoring can effectively predict DCI, guide the treatment and reduce the ischemic neurological deficits. Modified Fisher grade and MCAVm≥130 cm/s are the risk factors of DCI.

Surgical treatment for 61 patients with multiple lung lesions

PENG Yue, FENG Zhen, XIE Hounai, WANG Hui, LI Meng, REN Wangang, LIU Tong, PENG Zhongmin

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 42-46. doi:10.6040/j.issn.1671-7554.0.2017.141

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Objective To provide experiences for clinical diagnosis and treatment by analyzing the surgical outcomes for patients with multiple lung lesions. Methods Clinical data of 61 patients with clinical diagnosis of synchronous multiple primary non-small cell lung cancer(SMPLC)were collected from May 2012 to Apr. 2016 in our hospital. The clinicopathologic features, surgical treatment and overall survival(OS)were retrospectively analyzed. Results Among the 61 patients, 47 patients were verified with more than one malignant tumors. Ten patients were verified with only one malignant tumor, and all lesions of the other 4 patients were benign. Forty-one patients were finally diagnosed with SMPLC after surgical treatment. The 1-year and 3-year OS rates were 97.0% and 77.5%, respectively. Smaller dimension of maximal tumor(χ2=10.918, P=0.012), lesions with less solid ingredient(χ2=10.754, P=0.005), lymph nodes metastases negative(χ2=10.234, P=0.001)and earlier TNM stage(χ2=12.068, P=0.007)were correlated with better OS. Conclusion For patients with multiple lung lesions, if the diagnosis of SMPLC can not be excluded and there is no lymph nodes metastases in thoracic computed tomography, surgical treatment can be considered preferentially.

Relationship between PADI2 and genetic susceptibility in various human tumors

LI Chang, ZHANG Qian, MA Fang, XIE Qi, CHANG Xiaotian

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 47-53. doi:10.6040/j.issn.1671-7554.0.2016.133

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Objective To investigate the expression of peptidyl demitasse isoform 2(PADI2), a PAD family member, in various tumor tissues and the blood of patients and to investigate the correlation between PADI2 encoding gene and tumor risks. Methods Sequenom MassARRAY genotyping assay was used to determine the potential association of tag single nucleotide polymorphisms(SNPs)including rs2746533, rs79395834, rs2076616, rs10788656 in PADI2 gene to various tumor types(breast cancer, cervical cancer, esophageal cancer, stomach cancer, liver cancer, lung cancer, ovarian cancer, colon cancer, rectal cancer and thyroid cancer). Immunohistochemistry was used to determine the PADI2 expression and location in tumor tissues. ELISA was used to detect the PADI2 level in blood of the tumor 山东大学学报 (医学版)55卷11期 -李昌,等.PADI2与人多种肿瘤的遗传易感性的关系 \=-patients. Results The case-control analysis showed a significant association between rs2746533, rs2076616 and rs10788656 and breast cancer, cervical carcinoma, esophageal carcinoma, gastric carcinoma, lung cancer and rectal carcinoma risks. PADI2 expression significantly increased in 95% of the patients with breast invasive ductal carcinoma, 97.5% of the patients with colonal adenocarcinoma, 88% of the patients with esophageal squamous cell carcinoma, and 92.5% of the patients with lung cancers and 90% of thyroid carcinoma papillary carcinoma samples, but not in the corresponding healthy tissues, except that in some mesenchymal cells and endothelial cells. A two-fold increase in PADI2 expression was detected in the blood of 86% of patients with liver cancer, 38% of patients with cervical carcinoma and 32% of patients with gastric carcinoma. Conclusion PADI2 has genetic susceptibility to many kinds of tumor and is highly expressed in various tumor tissues and blood of the patients. The finding suggests an important role for PADI2 in tumorigenesis.

Sonographic findings and pathological features of non-mass pure ductal carcinoma in situ

ZHANG Peipei, LIU Dequan, WANG Bei, HE Shuqian, LI Fei, DING Hongyu, SUN Hongjun

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 54-58. doi:10.6040/j.issn.1671-7554.0.2016.1274

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Objective To explore the characteristic sonographic findings and pathological features of non-mass pure ductal carcinoma in situ(DCIS). Methods The sonographic findings of 32 cases of non-mass pure DCIS treated during Sep. 2014 and Jun. 2016 were retrospectively analyzed. The edge of the lesion, internal echo, local gland hyperplasia, microcalcification and blood flow resistance index(RI)were reviewed. Results The major manifestations included focal gland hyperplasia and uneven internal echo intensity. Color Doppler showed rich blood flow around the lesions, with RI>0.7. Mammoductal ectasis and microcalcifications could be observed. Most DCIS were of high grade. Conclusion Non-mass pure DCIS manifests with focal gland hyperplasia disorders and uneven internal echo intensity. Most DCISs are of high pathological grade. Color Doppler and detection of RI can be helpful in the diagnosis of DCIS.

Application of flash spiral acquisition by dual-source CT in children with cardiovascular airway constriction

LI Yuanyuan, WANG Ximing, WANG Long, JI Congshan, DUAN Yanhua,CHENG Zhaoping, LIU Yanping, CHEN Jing

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 59-64. doi:10.6040/j.issn.1671-7554.0.2016.1529

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Objective To explore the application of flash spiral acquisition by dual-source CT in the diagnosis of congenital heart disease complicated with cardiovascular airway constriction. Methods Children suspected with cardiovascular airway compression underwent flash spiral acquisition by dual-source CT during Jan. 2013 and Dec. 2015, and 99 山东大学学报 (医学版)55卷11期 -李媛媛,等.双源CT Flash扫描在心血管源性气道狭窄患儿诊断中的临床应用 \=-children were finally included in this study, including 40 males and 59 females. The mean age was 22 months and mean body weight was(10±7.7)kg. The dose length product(DLP)was recorded to calculate effective dose(ED). Images were analyzed by two experienced radiologists using a 5-grade scoring system subjectively with post-processing technique. The diagnostic criteria were adopted to determine airway constriction. Multiple planar reformation(MPR)and volume rendering(VR)were used to show the anatomic structures around the narrow segment, and to define the responsible anomalies and location of the airway constriction. The characteristics of pulmonary lesions were observed in lung window and minimum intensity projection(MinIP). Results The average DLP was(7.32±6.19)mGy·cm, and average ED was(0.39±0.20)mSv. All images were diagnosable. The two radiologists made good agreement(K=0.754, P<0.05). With different age groups, the younger the patients, the higher proportion of cardiovascular airway constriction and pulmonary anomalies(Z=-3.83, P<0.001). Of all 99 children, a total of 104 constrictions were diagnosed as tracheobronchial compression caused by vascular abnormalities, including pulmonary arterial hypertension in 38 cases(36.5%), coarctation of aorta in 32 cases(30.8%), right-sided aortic arch in 14 cases(13.5%), innominate artery tracheal compression in 12 cases(11.5%), pulmonary artery sling in 6 cases(5.8%), double aortic arch in 1 case(1.0%)and left atrial enlargement in 1 case(1.0%). Secondary pulmonary lesions were also detected, including ground glass opacity in 36 cases, consolidation in 19 cases, emphysema in 66 cases and post-obstructive pulmonary atelectasis in 7 cases. The difference between the different types of primary heart diseases and the locations of the airway constriction was statistically significant(P<0.001). Airway constrictions caused by congenital heart disease were most likely to occur on the left main bronchus. Conclusion Flash spiral acquisition by dual-source CT can diagnose congenital heart disease with airway compression simultaneously, and provide information for clinical diagnosis and treatment.

Mini-Nutritional Assessment and Short-Form Mini-Nutritional Assessment in evaluating nutritional status of the elderly in community

ZHANG Huanhuan, WANG Cuiping, ZHAO Min, GUO Dongmei, CHEN Liyong, LIN Xinying

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 65-70. doi:10.6040/j.issn.1671-7554.0.2017.107

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Objective To compare the value of Mini-Nutritional Assessment(MNA)and the Short-Form Mini-Nutritional Assessment(MNA-SF)in evaluating the nutritional status of the elderly in community. Methods A total of 576 elderly ≥60 years in Jinan City were randomly selected. MNA and MNA-SF were used to evaluate the nutritional status of the population. The anthropometric parameters and laboratory indexes were also measured. Results MNA took 10 min to complete while MNA-SF only needed 3 min. MNA showed that the proportion of adequate nutritional status was 79.93%, and that of potential malnutrition was 20.07%, and no malnutrition was found. MNA-SF showed that the proportion of adequate nutritional status was 80.48% and that of malnutrition was 19.52%. Both of them were positively correlated with BMI, MAC, CC, WC, HC, TSF, SSF, ALB and other traditional nutritional evaluation indicators(r=0.001-0.530, P<0.05). The Pearson correlation coefficient between MNA and MNA-SF scores was 0.823(P< 山东大学学报 (医学版)55卷11期 -张欢欢,等.利用微型营养评价法和微型营养评价精法评价社区老年人的营养状况 \=-0.05). The Spearman correlation coefficient between MNA and MNA-SF was 0.681(P<0.05). MNA and MNA-SF had good consistency in evaluating nutritional status(κ=0.681, P<0.001). With BMI<18.5 as the evaluation criteria of malnutrition, the sensitivity and specificity of MNA were 76.2% and 93.4% respectively, and the sensitivity and specificity of MNA-SF were 93.4% and 100% respectively. Conclusion Both MNA and MNA-SF can be used to evaluate the nutritional status of elderly from community, and MNA-SF is more simple, rapid and effective.

Impact of extreme temperatures on cardiovascular deaths in Jinan City

HAN Jing, ZHANG Jun, ZHOU Lin, FANG Qiaoling, LIU Shouqin, ZHANG Ji, ZHANG Ying

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 71-74. doi:10.6040/j.issn.1671-7554.0.2016.1009

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Objective To investigate the relationship between extreme temperatures and daily number of cardiovascular deaths in Jinan City, and to provide theoretical basis for preventive measures. Methods Data of daily number of cardiovascular deaths and meteorological variables over the period of 2011-2014 were collected. Cold spells / Heat waves were defined as ≥3 consecutive days with mean temperature ≤5th percentile or ≥95th percentile, respectively. The time-series adjusted Poisson regression was adopted to assess the effects of extreme temperatures on cardiovascular deaths by controlling for lagged effects and other confounders. Results A clear seasonal distribution of daily number of cardiovascular deaths was observed. Extreme temperatures significantly increased the daily number of cardiovascular deaths(P<0.01). Both cold spell and heat wave significantly increased the risk of deaths with RR=1.06(95%CI: 1.03-1.10)and RR=1.03(95%CI: 1.00-1.06), respectively(P<0.05). The elderly group(≥65 years)was more vulnerable to heat wave exposure, while all population regardless of age and gender were vulnerable to cold spell. 山东大学学报 (医学版)55卷11期 -韩京,等.极端气温对济南市心脑血管疾病死亡的影响 \=- Conclusion Both could spells and heat waves increase the risk of daily cardiovascular death in Jinan City. Our findings suggest that public health policies and interventions during extreme temperatures should target the whole population.

Status of human resources in social organizations for HIV/AIDS prevention and control in Shandong Province

ZHANG Tongchao, ZHAO Liting, LÜ Cuixia, ZHANG Xiaofei, DONG Lei, LI Lin, ZHENG Jietao, FU Jihua, WANG Zhiping

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 75-79. doi:10.6040/j.issn.1671-7554.0.2016.1678

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Objective To investigate the status of human resources for AIDS control in Shandong Province, and to provide references for social organizations involved. Methods A self-designed questionnaire was used to survey all personnel in social organizations involved with AIDS control and prevention. Results A total of 241 questionnaires were distributed and 234 solid ones were collected. The respondents included 162 male(69.65%)and 72 female(30.35%), aged 36.86±11.25 years averagely. Of all respondents, 60.69% had obtained college degree, and 38.03% had medical background; 35.09% were full-time staff, and 59.83% were peer education members. The main reasons for taking such a job were to help people in need, to achieve personal values, to know more friends, and to seek psychological sustenance 山东大学学报 (医学版)55卷11期 -张同超,等.山东省参与艾滋病防治社会组织人力资源现况 \=-in the organizations. Conclusion The personnel in AID control and prevention organizations in Shandong Province has relatively high level of education, and acknowledge the public welfare of such organizations. However, the proportion of full-time staff is low, and there exists staff loss in the organizations.

Price and the accessibility of essential medicines for the elderly with chronic diseases in the Asia Pacific Region

JIANG Mengya, LOU Hongxiang, SUN Qiang, WANG Haipeng

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 80-84. doi:10.6040/j.issn.1671-7554.0.2016.1630

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Objective To study the price and accessibility of essential medicines for the elderly with chronic diseases in the six countries of Asia Pacific, and to provide evidence and policy recommendations. Methods The secondary data, which were adjusted according to the inflation/deflation, were acquired from the researches of WHO/HAI and analyzed. Results The availability values of lowest price generic and originator brand in public hospital in the six countries were 5.0%-80.0% and 1.8%-15.4%, while those in private hospital were 11.7%-54.5% and 10.0%-65.6%. The affordability values of lowest price generic and originator brand in public hosipital were 0-1.2 and 0-5.0 times of daily wages, while those in private hospital were 0.3-2.0 and 1.2-7.0 times of daily wages. The median price ratios(MPRs)of lowest price generic and originator brand in public hospital were 0-32.88 and 0-79.13, while those in private hospital were 0.92-46.21 and 13.84-103.75. Conclusion The availability of essential medicines for chronic diseases in the six countries is low, the price of the medicines is higher than the international reference price, and the affordability of the medicine is poor. The accessibility of the medicine must be improved.

Application of copper wire percutaneous insertion in the treatment of cavernous hemangioma of penis: with 10 cases

WANG Tianyin, SUN Peng, WU Tong, ZHANG Dong

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(11): 85-88. doi:10.6040/j.issn.1671-7554.0.2017.581

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Objective To study the safety, feasibility and cosmetic effect of copper wire therapy in treating cavernous hemangioma of penis. Methods Ten patients age ranging from 12 to 32 years old with penile cavernous hemangiomas entered our study from June 2008 to June 2016. The lesion was located in the head of penis in 4 cases and in the body of penis in 6 cases. All patients received treatments with percutaneous copper wires. Perioperative data was analyzed. All possible complications were noted and cosmetic result was evaluated. Patients were followed up after discharge from the hospital. Results All the operations were successful and no obvious complications were observed. The patients were satisfied with the aesthetic outcomes. Follow-up time ranged from 1 to 5 years. Recurrence was discovered in a patient with the largest lesion of corpus penis 2 months after the treatment. Secondary procedure was carried out for this patient with the same technique and no lesions were found later. Conclusion Copper wire therapy was a simple, safe and useful option for penile cavernous hemangioma.

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