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Relationship between apolipoprotein E gene polymorphism and type 2 diabetes mellitus with arteriosclerotic cerebral infarction

HAN Feng1, REN Jian-min2， LIU Xiao-li1, ZHENG Shu-ting1, YANG Li-na1   

  1. 1. Department of Endocrinology, Zhangqiu People′s Hospital, Jinan 250200, China;2. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2007-11-28 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: REN Jian-min

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Abstract: To explore the relationship between apolipoprotein E (ApoE) gene polymorphism and dyslipidemia as well as arteriosclerotic cerebral infarction (ACI )in type 2 diabetic patients. Methods136 patients with type 2 diabetes mellitus, 64 patients with ACI and 72 patients without ACI, and 60 healthy controls were determined for the ApoE gene polymorphism by PCRRFLP. Results① Differences of distribution frequency in genotype and allelomorphic gene between type 2 diabetic patients and controls were insignificant. ② The TC and LDLc levels in group ∈4 were the highest while the lowest were in group ∈2 (P＜0.01). ③ 11 cases of the ∈4 allelle were found in the type 2 diabetic group with ACI and 4 were found in the type 2 diabetic group without ACI (χ2=4.672，P＜0.05). ConclusionThe ApoE ∈4 allele is related to hyperlipoidemia and the ∈4 allele is possibly a risk factor of type 2 diabetes mellitus.

Key words: Diabetes mellitus, Non-insulin-dependent, Dyslipidemia, Arteriosclerotic cerebral infarction, Apolipoprotein E gene, Polymorphism

CLC Number: 

  • R578.1
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