JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (4): 71-74.doi: 10.6040/j.issn.1671-7554.0.2014.808

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Relationship between polymorphisms of Parkin gene and the risk of Parkinson's disease in Han nationality of Shandong Province

CHEN Si1, WANG Muchuan2, REN Nannan3, XU Wei1, WANG Lingling1, LUAN Haihui1, MA Jun1, LIU Yiming1   

  1. 1. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. School of Medicine, Shandong University, Jinan 250012, Shandong, China;
    3. Department of Neurology, Jinan Central Hospital, Jinan 250013, Shandong, China
  • Received:2014-11-10 Revised:2015-01-22 Online:2015-04-10 Published:2015-04-10

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Abstract: Objective To investigate the relationship between polymorphisms in Parkin gene and the risk of Parkinson's disease(PD) in Han nationality of Shandong province. Methods The alleles of three polymorphisms(Ser167Asn,Val380Leu and Arg366Trp)in Parkin gene in 145 PD patients(PD group) and 126 people who undertook health examination(control group) in Han population of Shandong Province were analyzed by DNA sequencing and restricted endonuclease digestion. PD group included 67 patients with early-onset Parkinson's disease(EPOD) and 78 patients with late-onset parkinson's disease(LOPD). Results There were no significant difference in the three polymorphisms(Ser167Asn, Val380Leu and Arg366Trp)between PD group and control group; In PD group, The allele frequencies in Ser167Asn and Arg366Trp of EOPD patients showed no significant difference with LOPD patients. The allele frequency in Val380Leu of EOPD patients was significantly higher than LOPD patients(P=0.01, OR=3.39, 95%CI:1.287-8.931). Conclusion The three polymorphisms(Ser167Asn, Val380Leu and Arg366Trp)in Parkin gene may be not associated with PD in Han nationality of Shandong province, and Val380Leu may make the onset age of PD in advance.

Key words: Polymorphism, Shandong Province, Parkinson's disease, Parkin gene

CLC Number: 

  • R742.5
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