JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (8): 75-80.doi: 10.6040/j.issn.1671-7554.0.2014.163

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Meta-analysis of TNFAIP3 gene polymorphism with rheumatoid arthritis

WANG Weiyan1, YANG Qingrui1, YUAN Yuan2, YANG Xinglin1, ZHANG Yuanchao1   

  1. 1. Department of Rheumatology and Immunology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. Department of Comprehensive Health Care, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2014-03-21 Revised:2014-07-01 Online:2014-08-10 Published:2014-08-10

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Abstract: Objective To validate the association between rheumatoid arthritis (RA) and TNFAIP3 gene polymorphism. Methods A total of 6 SNPs in TNFAIP3 (rs6920220, rs2230926, rs5029937, rs10499194, rs2327832, rs13207033) which had been extensively examined were selected. Published studies on RA and TNFAIP3 were retrieved and a Meta-analysis was conducted. Results Altogether 18 studies with 27 554 RA patients and 39,664 controls were included. The comprehensive analysis indicated that the gene polymorphism of rs6920220, rs2230926 and rs5029937 was associated with RA (P<0.000 01, P=0.03, P=0.002). The gene polymorphism of rs2327832 and rs13207033 was not associated with RA (P=0.27, P=0.05). The subgroup analysis revealed that the gene polymorphism of rs10499194 was associated with RA in white people [OR= 0.87 (0.80-0.95), P=0.002]. The gene polymorphism of rs10499194 was associated with RA in yellow people[OR=1.28(1.13-1.46), P=0.000 1]. Conclusion The Meta-analysis reveals that the gene polymorphism of rs6920220, rs2230926 and rs5029937 is associated with RA. The association between the gene polymorphism of rs10499194 and RA has racial differences.

Key words: Rheumatoid, arthritis, Tumor necrosis factor alpha induced protein 3, Polymorphism, Meta-analysis

CLC Number: 

  • R593.22
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