JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Correlation between polymorphism of aldose reductase gene and retinopathy in type 2 diabetes mellitus

ZHANG Ji-hui1，WANG Hong-yi2，LI Shu-yuan1   

  1. 1. Department of Endocrinology; 2. Department of Special Clinical Laboratory, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, China
  • Received:2007-11-05 Revised:1900-01-01 Online:2008-04-16 Published:2008-04-16
  • Contact: LI Shu-yuan

PDF (PC)

275

Abstract: ObjectiveTo study the relationship between polymorphism of (AC)n in 5′end of the AR gene and background diabetic retinopathy(BDR). Methods74 patients with diabetes mellitus (DM), of them, 39 with BDR and 35 without, and 40 controls were enrolled in this study. PCRagarose gel electrophoresise was used to determine the polymorphism marker of (AC)n dinucleotide of 5′end of the AR gene. Results① 7 alleles, mostly were Z, Z＋2, and Z-2 alleles were observed in type 2 diabetes mellitus and controls. ② Frequency of allele Z-2 was significantly higher in the BDR group than in the nondiabetic retinopathy(NDR) group and the control group, however, frequency of allele Z+2 was significantly lower in the BDR group than in the NDR group and the control group. Conclusion 7 alleles were found in 5′end of the AR gene in type 2 DM patients in the Shandong area, of them, Z-2 allele might be the susceptible gene and Z＋2 allel might be the protective gene.

Key words: Diabetes Mellitus, type 2, Aldose Reductase, Genes, Retinopathy

CLC Number: 

  • R587.1
[1] YU De-Xin, CAEI Ti-Gong, MA Xiang-Xing, ZHANG Xiao-Ming, LI Chuan-Fu. Angiogenesis and maturation of hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 51-54.
[2] JIAO Fengping, ZHANG Haitao, ZHAO Yinghui, TIAN Zhaoju, YANG Shulin. Preliminary study of tissue distribution and safety of HSV-2 DNA vaccine in mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 38-42.
[3] ZONG Shuai, XIAO Dongjie, LIU Hua, JIA Yanfei, MA Xiaoli, LI Huanjie, LI Ping, ZHENG Yan, WANG Yunshan. Expression of CSN5 and its correlation with the prognosis of gastric carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 12-16.
[4] SU Ping, YANG Yachao, YANG Yang, JI Jiadong, DAYIMU Alimu, LI Min, XUE Fuzhong, LIU Yanxun. Prediction models on the onset risks of type 2 diabetes among the health management population [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(6): 82-86.
[5] LI Shuai, WANG Yalin, SUN Zhongwen, ZHU Meijia. Expression changes and mechanism of Nod-like receptor protein 3 inflammasome in the cerebral microvascular endothelial cells in type 2 diabetes mellitus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 6-11.
[6] JIAO Fengping, WANG Yu, YU Ailian, TIAN Zhaoju, YANG Shulin. Immunogenicity of the eukaryotic expression vector pcDNA3.1(-)-P6-gBCTL-TBK-1 [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 75-78.
[7] DU Heng, YUAN Xiaodong. Progress in the etiology and pathogenesis of Alzheimers disease [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 21-27.
[8] WANG Bishi, SHAN Junqi, HOU Qingsheng, GONG Weipeng, ZHU Zhenyu, GUO Hongliang. Effort of CD11b+ / CD66b- phenotype myeloid cells on the progression of colon cancer and liver metastasis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 41-45.
[9] CHEN Yikun, WANG Ketao, WANG Huayang, SHAO Qianqian, TAN Wanye, SONG Xiaobin, QU Xun, WEI Fengcai. Regulatory role of KIF4A in the expression of angiogenesis- associated factors of macrophages [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 39-43.
[10] YANG Yang, ZHANG Guang, ZHANG Chengqi, SONG Xinhong, XUE Fuzhong, WANG Ping, WANG Li, LIU Yanxun. A prediction model for type 2 diabetes risks: a cohort study based on health examination [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(9): 69-72.
[11] PENG Li, QIANG Ye, ZHAO Huichen, CHEN Shihong, YAO Weidong, LIU Yuantao. Clinical studies on type 2 diabetic patients treated with sitagliptin [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 60-63.
[12] LIN Dong, GUAN Qingbo. Association of serum testosterone level and non-alcoholic fatty liver disease in male patients with T2DM [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(7): 33-37.
[13] LIU Xiangyong, SUN Ying, LI Li. The effects of poly(ADP-ribose)polymerase inhibitor on the proliferation of breast cancer cell line MCF-7 and prostate cancer cell line 22RV1 with BRCA and PTEN gene silencing [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(5): 6-11.
[14] Muhadasi TUERXUNYIMING, Patamu MOHEMAITI, Tuolanguli MAIMAITIKUERBAN. Association of CDKAL1 rs10946398 C/A polymorphism with type 2 diabetes [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 75-85.
[15] ZHANG Hongxia, XU Yonghong, CHEN Li, GONG Huicheng. Detection of peripheral thrombomodulin and myeloperoxidase and their significance in adults with obstructive sleep apnea hypopnea syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 67-71.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd