成人阻塞性睡眠呼吸暂停低通气综合征外周血TM、MPO的检测及意义

doi:10.6040/j.issn.1671-7554.0.2016.645

Abstract

Abstract: Objective To investigate the detection and significance of serum thrombomodulin(TM)and myeloperoxidase(MPO)in adults with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods A total of 90 OSAHS patients treated during Mar. 2014 and Feb. 2016 were divided into 3 groups according to apnea hyponea index(AHI): mild group(n=30), moderate group(n=30)and severe group(n=30). Another 30 healthy people served as the control group. The peripheral blood was collected from the patients with fasting blood in the morning after patients received polysomnography(PSG). The serum TM and MPO levels were determined by enzyme-linked immunosorbent assay(ELISA). Patients in the severe group were treated with continuous positive airway pressure(CPAP)and surgery. After 6-8 days, the narrow airway plane was evaluated to determine appropriate approaches of surgery. TM, 山东大学学报 (医学版)54卷12期 -张红霞,等.成人阻塞性睡眠呼吸暂停低通气综合征外周血TM、MPO的检测及意义 \=- MPO and PSG were repeatedly detected and analyzed. Results The serum TM and MPO levels were positively correlated with the severity of OSAHS(P<0.05). There was no significant difference in TM and MPO levels between the mild OSAHS group and control groups(P>0.05), but there was difference between the moderate and control groups, and between severe and control groups(P<0.05). The BMI of the severe group increased significantly compared with that of the mild, moderate and control groups(P<0.05). There was no correlation between TM and MPO levels and BMI, age and sex(P>0.05). There was positive correlation between TM and MPO levels and AHI(P<0.05), and negative correlation with LsaO₂(P<0.05). In the severe OSAHS group, LsaO₂ significantly increased after comprehensive treatment, while the TM and MPO levels and AHI significantly decreased(P<0.05). Conclusion Increased peripheral TM and MPO levels are involved in the cardiovascular damage in OSAHS patients. Detection of TM and MPO levels helps to determine the patients condition and efficacy of treatment, and assess the risk of cardiovascular disease.

Key words: Cardiovascular damage, Pathogenesis, Myeloperoxidase, Thrombomodulin, Obstructive sleep apnea hypopnea syndrome

CLC Number:

R762

ZHANG Hongxia, XU Yonghong, CHEN Li, GONG Huicheng. Detection of peripheral thrombomodulin and myeloperoxidase and their significance in adults with obstructive sleep apnea hypopnea syndrome[J].JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 67-71.

References

[1] 张萍, 郭文佳. OSAHS与心血管疾病的研究进展[J]. 临床耳鼻咽喉头颈外科杂志, 2016, 30(6):442-445. ZHANG Ping, GUO Wenjia. The research progress of OSAHS and cardiovascular disease[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2016, 30(6):442-445.
[2] Feng J, Zhang D, Chen B. Endothelial mechanisms of endothelial dysfunction in patients with obstructive sleep apnea[J]. Sleep Breath, 2012, 16(2):283-294.
[3] 邱承杰, 邱春光, 韩战营, 等. 髓过氧化物酶在急性冠脉综合征危险分层中的作用[J]. 临床荟萃, 2010, 25(7): 5603-5604.
[4] Ramar K, Caples SM. Vascular changes, Cardiovascular disease and obstructive sleep apnea[J]. Future Cardiol, 2011, 7(2):241-249.
[5] 中华耳鼻咽喉科头颈外科杂志编辑委员会, 中华医学会耳鼻咽喉科头颈外科分会咽喉学组. 阻塞性睡眠呼吸暂停低通气综合征诊断和外科治疗指南[J]. 中华耳鼻咽喉头颈外科杂志, 2009, 44(2):95-96.
[6] 王杰, 李莹, 林忠辉, 等. 正压通气与上气道多平面手术治疗OSAHS研究进展[J]. 临床耳鼻咽喉头颈外科杂志, 2013, 27(18):1036-1040.
[7] Liu JN, Zhang JX, Lu G, et al. The effect of oxidative stress in myocardial cell injury in mice exposed to chronic intermittent hypoxia[J]. Chinese Medical Journal, 2010, 123(1):74-78.
[8] 蔡伟, 张秀伟, 张希龙, 等. 阻塞性睡眠呼吸暂停综合征、炎症因子与动脉粥样硬化间关系的研究进展[J]. 东南大学学报(医学版), 2015, 34(1):159-162.
[9] Brostrom A, Sunnergren O, Johansson P, et al. Symptom profile of undiagnosed obstructive sleep apnoea in hypertensive outpatients in primary care: a structural equation model analysis[J]. Qual Prim Care, 2012, 20(4):287-298.
[10] Komarowska H, Jaskula M, Stangierski A, et al. Influence of ghrelin on energy balance and endocrine physiology[J]. Neuro Endocrinol Lett, 2012, 33(8):749-756.
[11] Akinnusi ME, Laporta R, El-Solh AA. Lectin-like oxidized low-density lipoprotein receptor-1 modulates endothelial apoptosis in obstructive sleep apnea[J]. Chest, 2011, 140(6):1503-1510.
[12] 张庆伟, 王春婷, 王启志, 等. 丙酮酸乙酯对脓毒症大鼠小肠黏膜屏障的保护作用及其机制[J]. 山东大学学报(医学版), 2014, 52(5):30-34. ZHANG Qingwei, WANG Chunting, Wang Qizhi, et al. Protective effect and mechanism of ethyl pyruvate on the small intestine barrier in rats with sepsis[J]. Journal of Shandong University(Health Sciences), 2014, 52(5):30-34.
[13] 刘成桂, 彭端亮, 罗俊, 等. 联合检测MPOIL-6和hs-CRP对冠心病危险分层的价值[J]. 第三军医大学学报, 2011, 33(19):2061-2065. LIU Chengjia, PENG Duanliang, LUO Jun, et al. Value of risk stratification of coronary heart disease by combined determination of myeloperoxidase, interleukin-6 and high sensitivity C-reactive protein[J]. Journal of Third Military Medical University, 2011, 33(19):2061-2065.
[14] Heinecke JW. The role of myeloperoxidase in HDL oxidation and atherogenesis[J]. Curr Atheroscler Rep, 2007, 9(4):249-251.
[15] Brennan ML, Pennms MS, Van Lente F, et al. Prognostic value of myeloperoxidase in patients with chest pain[J]. N Engl J Med, 2003, 349(17):1595-1604.
[16] Baldus S, Heeschen C, Meinertz T, et al. Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes[J]. Circulation, 2003, 108(12):1440-1445.
[17] Chung S, Yoon IY, Lee CH, et al. The association of nocturnal hypoxemia with arterial stiffness and endothelial dysfunction in male patients with obstructive sleep apnea syndrome[J]. Respiration, 2010, 79(5):363-369.
[18] Takagi T, Morser J, Gabazza EC, et al. The coagulation and protein C pathways in patients with sleep apnea[J]. Lung, 2009, 187(4):209-213.
[19] 陈亚隽. TM与ICAM-1在阻塞性睡眠呼吸暂停低通气综合征合并高血压中的变化及意义[D]. 武汉: 华中科技大学, 2013.
[20] 郭欣, 吴志宇, 陈春悠. 阻塞性睡眠呼吸暂停低通气综合征中血清髓过氧化酶检测的意义[J]. 临床耳鼻咽喉头颈外科杂志, 2016, 30(6): 455-458.

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Detection of peripheral thrombomodulin and myeloperoxidase and their significance in adults with obstructive sleep apnea hypopnea syndrome

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