Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (12): 101-109.doi: 10.6040/j.issn.1671-7554.0.2021.1201

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Association between PM2.5 and PM10 exposure with gestational diabetes mellitus in certain areas of Shandong Province

XIAO Yang1, TAO Yu1, WANG Fangyi1, LIANG Yuxiu1, ZHANG Jin1, JI Xiaokang1,2, WANG Zhiping1,2   

  1. 1. School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. National Health and Medical Research Institute, Jinan 250002, Shandong, China
  • Published:2021-12-29

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Abstract: Objective To explore the relationship between fine particulate matter air pollution(PM2.5)and inhalable particulate matter(PM10)exposure before and during pregnancy with the risk of gestational diabetes mellitus(GDM), and to analyze the critical exposure window. Methods Based on the provincial platform database established by Health and Medical Research Institute of Shandong University, maternal data were collected from 2018 to 2020. With reference to daily monitoring data of PM2.5, PM10, NO2 and SO2 from 64 monitoring stations, and the longitude and latitude coordinates of pregnant womens addresses and monitoring station addresses, each subjects daily exposure concentration was calculated by inverse distance weighting(IDW)method to obtain the average exposure level before pregnancy, and in the first trimester and second trimester of pregnancy. The relationship between PM2.5 and PM10 exposure with the risk of GDM was analyzed with Logistic regression. The critical exposure window of PM2.5 and PM10 were determined with a distributed lag non-linear model. Results (1) A total of 18,407 people were eligible for inclusion, including 1,020 pregnant women with GDM, with a prevalence of 5.54%. (2) The average exposure concentration of PM2.5 in the second trimester was(52.45±18.26)μg/m3, which was higher than that before pregnancy ［(50.71±16.98)μg/m3］ and in the first trimester ［(51.08±17.15)μg/m3］, and the difference was statistically significant (F=21.98, P<0.001). The exposure concentration of PM10 before and during pregnancy had no statistically difference(F=2.36, P=0.124). (3) After the covariables were adjusted, the average exposure concentration of PM2.5 and PM10 in the second trimester were positively correlated with the risk of GDM, which increased by 18% and 15% with each increase of 10 μg/m3 exposure concentration(OR=1.18, 95%CI: 1.07-1.31; OR=1.15, 95%CI: 1.09-1.21). (4) The critical exposure window of PM2.5 and PM10 were 18-24 weeks and 14-22 weeks of pregnancy, respectively. Conclusion PM2.5 and PM10 exposure in the second trimester significantly increases the risk of GDM.

Key words: Gestational diabetes mellitus, Inhalable particulate matter, Fine particulate matter, Distributed lag non-linear model, Inverse distance weighted, Prevalence

CLC Number: 

  • R122.7
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