Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (11): 18-26.doi: 10.6040/j.issn.1671-7554.0.2018.692

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PM2.5 exposure promotes the genesis and development of atherosclerosis

WU Weidong1, AN Zhen1,2, GUI Shuangjun3, XU Jie1, FAN Wei1, SONG Jie1   

  1. 1. School of Public Health, Xinxiang Medical University, Xinxiang 453000, Henan, China;
    2. College of Life Sciences, Henan Normal University, Xinxiang 453000, Henan, China;
    3. The Third Clinical Medical College, Xinxiang Medical University, Xinxiang 453000, Henan, China
  • Published:2022-09-27

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Abstract: Fine particulate matter with aerodynamic diameter ≤ 2.5 μm(PM2.5)is a main contributor to haze, and constitutes a major risk to human health. Numerous epidemiological, clinical and toxicological studies have demonstrated that exposure to PM2.5 has been strongly associated with the development of cardiovascular disease(CVD). Short-term 山 东 大 学 学 报 (医 学 版)56卷11期 -吴卫东,等.PM2.5暴露促进动脉粥样硬化发生发展的研究进展 \=-exposure to PM2.5 triggers acute cardiovascular events, while long-term exposure significantly augments the risk of morbidity and mortality. CVDs have been attributed as the leading cause of death globally in the last decades, in which atherosclerosis(AS)is an essential event in the pathogenesis. Increasing evidence has revealed that both acute exposure to high concentrations or long-term exposure to low concentrations of PM2.5 can promote the progression and vulnerability of atherosclerotic plaques; however, the underlying mechanisms have not been elucidated yet. This review mainly summarizes the association between AS and PM2.5 exposures, and the underlying mechanisms of AS progression following PM2.5 exposures.

Key words: Fine particulate matter, Atherosclerosis, Cardiovascular disease

CLC Number: 

  • R574
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