Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (9): 9-14.doi: 10.6040/j.issn.1671-7554.0.2021.0936

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Targeting angiogenesis for disease therapy

CAO Yihai   

  1. Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 171 65, Sweden
  • Published:2021-10-15

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Abstract: Angiogenesis, the process of new blood vessel growth, is involved in the onset, development and progression of a number of human diseases, including the most common and lethal disorders such as cardiovascular disease, cancer, diabetes, inflammatory disease, and eye disease. Interference of angiogenesis by either enhancement or suppression provides exciting and important therapeutic approaches for treatment of these and other diseases. So far, a number of drugs targeting angiogenesis have received approvals from the FDA authorities in various countries for treatment of malignant and ophthalmological diseases. This article aims to provide mechanistic insights into angiogenesis in diseases, new therapeutic options, and therapeutically challenging issues in the clinic.

Key words: Angiogenesis, Cancer, Eye disease, Cerebrocardiovascular disease, Metabolic disease, COVID-19

CLC Number: 

  • R732.2
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