Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (9): 15-21.doi: 10.6040/j.issn.1671-7554.0.2021.0874

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Maintenance and function of tissue resident memory T cells in the kidney

YI Fan, LI Liang   

  1. Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan 250012, Shandong, China
  • Published:2021-10-15

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Abstract: Tissue resident memory T cells (T-RM), a recently discovered type of T lymphocytes, do not participate in systemic circulation but reside in organs. T-RM possess a unique differentiation regulation mechanism and contribute to immunomodulatory effect. They play an important role in the occurrence and development of many kinds of diseases and are expected to become a new therapeutic target. T-RM have also been found in the kidney. This review will focus on the formation, biological characteristics and maintenance of T-RM in the kidney and the role of T-RMin kidney diseases.

CLC Number: 

  • R692
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