JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (7): 82-89.doi: 10.6040/j.issn.1671-7554.0.2014.156

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Meta-analysis for consumption of cruciferous vegetables and the morbidity risk of renal cell carcinoma

ZHAO Long, GUAN Guangju   

  1. Department of Nephrology, the Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Received:2014-03-21 Revised:2014-06-04 Online:2014-07-10 Published:2014-07-10

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Abstract: Objective To evaluate the association between cruciferous vegetables (CV) consumption and the risk of renal cell carcinoma (RCC). Methods After the retrieval strategy and criteria for inclusion and exclusion were formulated, databases of ProQuest, Web of Science, EMBASE and PUBMED were searched for literatures publicized during Jan. 1966 to Dec. 2013. Pooled relative risks (RR) and the corresponding 95% confidence intervals (CI) were estimated by random-effect and fixed-effect models. Meta-regression was used to detect potential sources of heterogeneity. Subgroup analyses, cumulative meta-analysis and sensitivity analysis were also conducted. Results A total of 12 studies (6 case-control, 6 cohorts) were included in the analysis, involving 1 228 518 participants (5 773 RCC cases). An obvious negative correlation was found between CV and RCC risk [RR=0.81, 95% CI (0.72-0.91)]. In subgroup analyses, CV was obviously related to lower RCC risk among studies carried out in America [RR=0.77, 95%CI (0.70-0.86)]; nevertheless, CV had no obvious correlation with RCC risk among studies carried out in Europe [RR=0.87, 95%CI (0.71-1.07)]. Conclusion The results of the present Meta-analysis indicated that high consumption of CV is negatively correlated with RCC risk in Americans.

Key words: Cancer risk, Meta-analysis, Renal cell carcinoma, Cruciferous vegetables

CLC Number: 

  • R692
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