JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (1): 95-99.doi: 10.6040/j.issn.1671-7554.0.2013.473

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Meta-analysis of EARP1 gene polymorphism with ankylosing

YANG Xing-lin1, YANG Li-juan2   

  1. 1. Department of Rheumatology and Immunology; 2. Nursing Department,
    Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2013-08-02 Online:2014-01-10 Published:2014-01-10

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Abstract:

Objective  To validate the association of ankylosing spondylitis (AS) with ERAP1 gene polymorphism with Meta-analysis. Methods  Relevant studies on AS and ERAP1 were retrieved and a Meta-analysis was conducted, and then the statistics were analyzed with Reveman 5.0 software. Results  A total of 17 studies with 11411 AS patients and 16511 controls were included. Meta-analysis showed significant differences in minor allele frequencies of rs27044, rs30187, rs10050860, rs2287987, rs17482078, rs27434 and rs27037 between the two groups (P< 0.05). In addition, significant differences of genotype frequencies of these SNPs were also found between the AS cases and controls (P<0.05). Conclusion  ERAP1 gene polymorphism is related to the genetic susceptibility to AS.

Key words: Spondylitis, Polymorphism, Meta-analysis, Ankylosing, ERAP1

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