JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Effect of artificial liver on serum cytokine in the fulminant hepatic failure model in pigs

TIAN Jun1,　GENG Li-na1,　LI Ya-ming2,　LI En-gang1,　CUI Xian-quan1   

  1. 1. Department of Blood Purification, Qilu Hospital of Shandong University, Jinan 250012, China;2. Treatment Center of Artificial Liver, Beijing You′an Hospital, Beijing 100054, China
  • Received:2007-03-17 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: TIAN Jun

PDF (PC)

221

Abstract: To investigate the effects of plasma exchange (PE) combined with hemofiltration (HF) on the dynamic changes of serum cytokine TNF-α, IL-6 and IL-1β. MethodsThe fulminant liver failure animal models of mini-pigs were established with D-galactosamine, and they were randomly divided into the treatment group and the control group. After 24 hours and 48 hours, the treatment group received plasma exchange (PE) plus hemofiltration (HF) twice. The differences of cytokines in two groups were determined. ResultsThe cytokines TNF-α, IL-6 and IL-1β significantly increased with time in both the control group and the treatment group. There were no significant differences between the two groups before artificial liver therapy. However, after plasma exchange (PE) plus hemofiltration (HF), the change tendency of serum cytokines of the treatment group was significantly different from that of the control group. ConclusionEarly and enough combined non-bio-artificial liver(PE plus HF) can efficiently clear TNF-α, IL-6 and IL-1β and earn time for liver regeneration or liver transplantation.

Key words: Liver failure, Artificial liver, Cytokine, Animal model, Minipig

CLC Number: 

  • Ｒ659.3
[1] HU Yujing, WU Dayong, ZHANG Wenyan, BIAN Yanzhu, WEI Qiang, TIAN Congna, CHANG Shengli. Correlation between 99Tcm-MNLS hypoxic scintigraphy and hypoxia-inducible factor-1α after radiotherapy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(8): 30-34.
[2] YIN Ni, YANG Guanlin, JIANG Junwen, WANG Chuntian, WANG Fengyao, JIA Lianqun, GAO Xiaoyu, PAN Jiaxiang, LI Qin, LI Jia, FENG Yuanjie, GAO Yuzhu, ZHOU He, ZHANG Zhe. A reliable system to assess atherosclerosis model of Bama minipigs [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 1-5.
[3] YANG Yanjun, LIANG Jing, LI Fang, DU Lingxi. Effect of halofuginone on macrophage polarization in endometriosis mouse [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(9): 26-31.
[4] WANG Qingshi, CHEN Yunzhen, LIU Haichun, WU Wenliang, JIAO Guangjun, LI Xiaofeng, XU Daxia. Effects of inflammatory cytokines secreted by nucleus pulposus cells on proliferation and osteogenic ability of posterior longitudinal ligament fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 22-26.
[5] YU Guifang, CHEN Shudi, CHEN Xuezhu, HOU Kailian, LIANG Min. miR-196a promotes cell growth of HBx-HepG2 via targeting SOCS6 [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 14-19.
[6] YUAN Bing, LI Ranran, HAN Mingyong. Primary tumor regulates the pulmonary microenvironment in melanoma carcinoma model and facilitates lung metastasis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 13-18.
[7] ZHANG Mingming, AN Yonghui, HAN Caili, ZHANG Yingqi, MA Ming, LI Na, ZOU Changpeng. Clinical efficacy of combined cellular immunotherapy and photodynamic therapy for advanced esophageal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(1): 38-41.
[8] LI Xiuhua, LI Xiaoli, DUAN Ruisheng, ZHU Meijia, CAO Lili, LI Yanbin, WANG Si, YUE Longtao, MA Qinghai, LIU Fei. Effects of 1,25(OH)2D3 on the induction of immune tolerance in Lewis rats with EAMG [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(8): 5-10.
[9] ZHANG Peng, YUE Longtao, LI Heng, ZHANG Min, WANG Congcong, DUAN Ruisheng, DOU Yingchun. Therapeutic effects of traditional Chinese medicine Xuezhikang on experimental autoimmune neuritis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 1-5.
[10] FENG Qing, TAN Xiaodong. L161982 influences macrophage subtypes in rats with experimental autoimmune neuritis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(10): 21-25.
[11] YANG Yong-rong, LI Jun, LIANG Ye, LI Jin-du, LAN Jia-fu, LI Tian-zi. The study on association of TNF-α-238G/A gene polymorphisms in patients with oral lichen planus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(S1): 10-11.
[12] CHEN Guoling, REN Ran, ZHANG Yinghui, SONG Wei, KAO Xin, ZHANG Han. Significance and effect of emodin on activation of nuclear factor-κB in corneas of keratitis rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(9): 44-47.
[13] ZHAO Yan1, WANG Gang1, CHEN Dafang2, CHENG Yuhang1, CHEN Xueyan1. Plasma levels of IL-6, IL-10 and IL-12 and influencing factors in first-episode and neuroleptic-free schizophrenia patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(4): 70-73.
[14] YU Jian, YE Yao, HUANG Lili, LIU Xiaoling, MO Rufen, YANG Fan, HU Jing, ZHOU Yingqiong, HE Yongling. Pancreatic pathological and biochemical changes in a Bama miniature pig model of type 1 diabetes mellitus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(12): 10-14.
[15] SUI Xiangyu, ZHANG Xiangchun, ZHANG Guangyong, HU Sanyuan, WANG Yanlei, DAI Yong. Preliminary study in the protective role of p120 catenin in inflammatory lung injury [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(12): 41-44.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd