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Plasma levels of IL-6, IL-10 and IL-12 and influencing factors in first-episode and neuroleptic-free schizophrenia patients

ZHAO Yan1, WANG Gang1, CHEN Dafang2, CHENG Yuhang1, CHEN Xueyan1   

  1. 1. Department 5, Beijng Anding Hospital Affiliated to Capital Medical University, Beijing 100088, China;
    2. School of Public Health, Peking University, Beijing 100191, China
  • Received:2013-04-21 Online:2014-04-10 Published:2014-04-10

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Abstract: Objective  To investigate the plasma levels of interleukin-6 (IL-6), interleukin-10 (IL-10) and interleukin-12(IL-12) in first-episode and neuroleptic-free schizophrenia patients and their influencing factors. Methods  The 137 subjects were divided into the patient group (n=67) and control group (n=70). The plasma levels of IL-6, IL-10 and IL-12 were assayed by enzyme-linked immunosorbant assay (ELISA). The symptoms were measured by positive and negative syndrome scale (PANSS). Results  Compared with the control group, the patient group had the increased IL-6 levels (P=0.028) and decreased IL-10 levels (P=0.013). No statistical difference of IL-12 levels was found between the two groups (P=0.258). There existed positive correlations between negative subscore and IL-10 levels (β=1.9, P=0.011), and the amount of cigarettes and IL-12 levels (β=0.1, P=0.049). Conclusion  Schizophrenia is characterized by alteration of immunity and cytokine network damage. There may exist multi-form alterations of immunity among different subtypes and sexes of schizophrenia patients.

Key words: Schizophrenia, Cytokine, Interleukin, Immunology

CLC Number: 

  • R749.3
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