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Effect of artificial liver on serum cytokine in the fulminant hepatic failure model in pigs

TIAN Jun1,　GENG Li-na1,　LI Ya-ming2,　LI En-gang1,　CUI Xian-quan1   

  1. 1. Department of Blood Purification, Qilu Hospital of Shandong University, Jinan 250012, China;2. Treatment Center of Artificial Liver, Beijing You′an Hospital, Beijing 100054, China
  • Received:2007-03-17 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: TIAN Jun

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Abstract: To investigate the effects of plasma exchange (PE) combined with hemofiltration (HF) on the dynamic changes of serum cytokine TNF-α, IL-6 and IL-1β. MethodsThe fulminant liver failure animal models of mini-pigs were established with D-galactosamine, and they were randomly divided into the treatment group and the control group. After 24 hours and 48 hours, the treatment group received plasma exchange (PE) plus hemofiltration (HF) twice. The differences of cytokines in two groups were determined. ResultsThe cytokines TNF-α, IL-6 and IL-1β significantly increased with time in both the control group and the treatment group. There were no significant differences between the two groups before artificial liver therapy. However, after plasma exchange (PE) plus hemofiltration (HF), the change tendency of serum cytokines of the treatment group was significantly different from that of the control group. ConclusionEarly and enough combined non-bio-artificial liver(PE plus HF) can efficiently clear TNF-α, IL-6 and IL-1β and earn time for liver regeneration or liver transplantation.

Key words: Liver failure, Artificial liver, Cytokine, Animal model, Minipig

CLC Number: 

  • Ｒ659.3
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