Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (3): 81-85.doi: 10.6040/j.issn.1671-7554.0.2020.1633

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Effects of drinking Yin-Jiu-Shu on liver metabolizing enzymes in 30 healthy volunteers

XIANG Lin1*, CHEN Lamei1*, WANG Jingwen1, LI Haiming1, LI Haoyu1, WANG Ju1, FAN Yuchen1, WANG Kai1,2   

  1. 1. Department of Hepatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Institute of Hepatology, Shandong University, Jinan 250012, Shandong, China
  • Published:2021-04-06

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Abstract: Objective To explore the effects of a plant beverage, Yin-Jiu-Shu, on liver metabolizing enzymes. Methods A total of 30 healthy volunteers were enrolled. Before, 30 min, 60 min and 120 min after Yin-Jiu-Shu were administered, 5 mL pf venous blood was collected, and plasma was immediately separated to detect the levels of alcohol dehydrogenase(ADH), acetaldehyde dehydrogenase(ALDH), glutathione(GSH), glutathione S-transferase P1(GSTP1), and glutathione S-transferase M3(GSTM3)using enzyme-linked immunosorbent assay(ELISA). Results After Yin-Jiu-Shu was administered, the plasma levels of ADH, ALDH, GSH, GSTP1, GSTM3 significantly increased at 30 minute point(P=0.014), 120 minute point (P=0.016), 60 minute point(P=0.031), 30 and 60 minute points (P=0.046, P=0.012), 30 and 60 minute points(P=0.008, P=0.039), respectively. Conclusion Yin-Jiu-Shu can improve the levels of alcohol metabolism related enzymes and antioxidants, which might be its underlying mechanism to promote alcohol metabolism and protect liver.

Key words: Yin-Jiu-Shu, Alcohol dehydrogenase, Acetaldehyde dehydrogenase, Glutathione, Oxidative stress

CLC Number: 

  • R575
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