Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (3): 79-84.doi: 10.6040/j.issn.1671-7554.0.2017.097

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Association of ApoE gene polymorphism and risk of atrial fibrillation among Han people in Shandong Province

ZHANG Xiuling, ZHANG Lei, LIU Dan, LIANG Jiangjiu   

  1. Health Care Department of Cardiology, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2017-01-24 Published:2022-09-27

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Abstract: Objective To investigate the association of the polymorphism of codon 112 and codon 158 in the ApoE gene and risk of atrial fibrillation(AF)in Han people of Shandong Province. Methods A total of 92 diagnosed AF cases were included in the AF group and 93 hospitalized patients over the same period were selected as control group. The general clinical information and whole blood of all patients were collected, and then the genomic DNA was extracted. The polymorphisms of 112 locus and 158 locus in ApoE gene were detected with microarray. The count data were compared with chi square test and the Fisher exact test was used when the count was less than 5. The measurement data were compared with t test. The AF-related factors were analyzed with binary Logistic regression analysis. Results There were significant differences in the genotype frequency and allele frequency at codon 112 between the AF group and control group(P<0.05), while there were no significant difference at codon 158(P>0.05). There was statistical difference in the phenotype frequency of ApoE between the AF group and control group(P<0.05). People who carried ApoE4 had a higher risk of AF. Conclusion ApoE gene polymorphism is associated with the risk of AF among Han people in Shandong Province. ApoE4 is a sensitive phenotype and people who carry ApoE4 are more likely to develop AF than those who do not.

Key words: Apolipoprotein E, Polymorphism, Atrial fibrillation, Inflammation, Oxidative stress

CLC Number: 

  • R714.252
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