Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (9): 30-36.doi: 10.6040/j.issn.1671-7554.0.2021.0924

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Immunomodulatory effects of bile acid in hepatointestinal diseases

ZHANG Zhaoying, MA Chunhong   

  1. School of Basic Medicine, Shandong University, Jinan 250012, Shandong, China
  • Published:2021-10-15

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Abstract: Bile acid, the final product of cholesterol catabolism in liver and the main component of bile, is critical for the emulsification and absorption of lipids. Dysregulation of bile acid metabolism is closely related to various hepatic and intestinal diseases, including hepatocellular carcinoma and colorectal cancer. At present, the clinical drugs targeting bile acid are widely utilized. Immune cells play an important role in the process of hepatointestinal diseases. Bile acid is closely related to liver and intestine immune homeostasis, affecting the differentiation and function of various immune cells, and thus affecting the occurrence and development of diseases. In this paper, we will review the regulation effect of bile acid on hepatointestinal immune cells in order to develop new therapeutic methods for hepatointestinal diseases by using bile acid.

Key words: Bile acid, Bile acid receptor, Hepatointestinal inflammation, Immune homeostasis, Immune cells

CLC Number: 

  • R575.203
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