Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (8): 24-31.doi: 10.6040/j.issn.1671-7554.0.2021.0794

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Research progress of maternal-fetal immunomodulatory mechanism

QIAO Chong, WANG Tingting   

  1. Department of Obstetrics and Gynaecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, Liaoning, China
  • Published:2021-09-16

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Abstract: The maternal-fetal interface develops tolerance to the homohemiallogeneic fetus while maintaining defense against infection, which has aroused great concern in reproduction and immunology. The maternal-fetal interface is a key site for the establishment and maintenance of normal pregnancy, which is composed of trophoblast cells, decidual immune cells and decidual stromal cells. Studies on the immune mechanism of the maternal-fetal interface help to elucidate the pathogenesis of many human pregnancy complications. In this paper, the research achievements of maternal-fetal immunity in recent years are summarized, and the key cellular functions of maternal-fetal interface and the interactions between cells and cytokines are described, aiming to elaborate the mechanism of maternal-fetal immune regulation.

Key words: Maternal-fetal interface, Trophoblast cell, Decidual immune cells

CLC Number: 

  • R714.03
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