Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (8): 63-71.doi: 10.6040/j.issn.1671-7554.0.2022.1479

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Expression of ECT2 in uterine corpus endometrial carcinoma and its clinical significance based on bioinformatics database

LIU Teng, MA Yingchun   

  1. The First Affiliated Hospital of Shandong First Medical University &
    Shandong Provincial Qianfoshan Hospital, Jinan 250012, Shandong, China
  • Published:2022-07-27

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Abstract: Objective To analyze the expression and potential function of ECT2 in uterine corpus endometrial carcinoma(UCEC)through multiple databases and to explore the prognosis. Methods The hub genes of UCEC were screened with GEO, STRING and Cytoscape. Kaplan-Meier analysis was performed in combination with TIMER2.0, UALCAN and Tumor Genome Atlas(TCGA). The differentially expressed genes(DEGs)were screened and functional enrichment analysis was performed using online analysis tools of Linked Omics and Metascape. The correlation between hub genes and pan-cancer immune infiltrating cells was analyzed with TIMER2.0. Results A total of 245 DEGs were screened out. ECT2 was the key gene, and its expression was correlated with the grade, stage, prognosis and survival of UCEC patients. ECT2 was also correlated with tumor proliferation and immune infiltration. Conclusion ECT2 is highly expressed in UCEC and closely related to the dismal prognosis, which may provide a new target for the treatment of this disease.

Key words: Uterine corpus endometrial carcinoma, GEO datebase, Bioinformatics analysis, Immune cells, Cell cycle

CLC Number: 

  • R737.33
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