Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (8): 63-71.doi: 10.6040/j.issn.1671-7554.0.2022.1479

Previous Articles     Next Articles

Expression of ECT2 in uterine corpus endometrial carcinoma and its clinical significance based on bioinformatics database

LIU Teng, MA Yingchun   

  1. The First Affiliated Hospital of Shandong First Medical University &
    Shandong Provincial Qianfoshan Hospital, Jinan 250012, Shandong, China
  • Published:2022-07-27

PDF (PC)

147

Abstract: Objective To analyze the expression and potential function of ECT2 in uterine corpus endometrial carcinoma(UCEC)through multiple databases and to explore the prognosis. Methods The hub genes of UCEC were screened with GEO, STRING and Cytoscape. Kaplan-Meier analysis was performed in combination with TIMER2.0, UALCAN and Tumor Genome Atlas(TCGA). The differentially expressed genes(DEGs)were screened and functional enrichment analysis was performed using online analysis tools of Linked Omics and Metascape. The correlation between hub genes and pan-cancer immune infiltrating cells was analyzed with TIMER2.0. Results A total of 245 DEGs were screened out. ECT2 was the key gene, and its expression was correlated with the grade, stage, prognosis and survival of UCEC patients. ECT2 was also correlated with tumor proliferation and immune infiltration. Conclusion ECT2 is highly expressed in UCEC and closely related to the dismal prognosis, which may provide a new target for the treatment of this disease.

Key words: Uterine corpus endometrial carcinoma, GEO datebase, Bioinformatics analysis, Immune cells, Cell cycle

CLC Number: 

  • R737.33
[1] Matteson KA, Robison K, Jacoby VL. Opportunities for early detection of endometrial cancer in women with postmenopausal bleeding[J]. JAMA Intern Med, 2018, 178(9): 1222-1223.
[2] Ledford LRC, Lockwood S. Scope and epidemiology of gynecologic cancers: an overview[J]. Semin Oncol Nurs, 2019, 35(2): 147-150.
[3] Chen S, Wang LL, Sun KX, et al. LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein[J]. Biochim Biophys Acta Mol Basis Dis, 2018, 1864(9 Pt B): 3013-3021.
[4] 王铭洋, 范文生, 叶明侠, 等. 子宫内膜癌分子分型及临床应用研究进展[J]. 现代妇产科进展, 2021, 30(4): 307-310, 313.
[5] Bell DW, Ellenson LH. Molecular genetics of endometrial carcinoma[J]. Annu Rev Pathol, 2019, 14: 339-367. doi: 10.1146/annurev-pathol-020117-043609.
[6] Pedersen CB, Nielsen FC, Rossing M, et al. Using microarray-based subtyping methods for breast cancer in the era of high-throughput RNA sequencing[J]. Mol Oncol, 2018, 12(12): 2136-2146.
[7] Vasaikar S, Straub P, Wang J, et al. LinkedOmics: analyzing multi-omics data within and across 32 cancer types[J]. Nucleic Acids Res, 2018, 46: D956-D963.
[8] Zhou Y, Zhou B, Pache L, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets[J]. Nat Commun, 2019, 10(1): 1523.
[9] Irvin WP, Rice LW, Berkowitz RS. Advances in the management of endometrial adenocarcinoma. A review[J]. J Reprod Med, 2002, 47(3): 173-190.
[10] Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020[J]. CA Cancer J Clin, 2020, 70(1): 7-30.
[11] Arend RL, Jones BA, Martinez A, et al. Endometrial cancer: molecular markers and management of advanced stage disease[J]. Gynecol Oncol, 2018, 150(3): 569-580.
[12] Piulats JM, Guerra E, Gil-Martín M, et al. Molecular approaches for classifying endometrial carcinoma[J]. Gynecol Oncol, 2017, 145(1): 200-207.
[13] Nuñez-Olvera SI, Gallardo-Rincón D, Puente-Rivera J, et al. Autophagy machinery as a promising therapeutic target in endometrial cancer[J]. Front Oncol, 2019, 9: 1326. doi: 10.3389/fonc.2019.01326.
[14] Raffone A, Travaglino A, Mascolo M, et al. Histopathological characterization of ProMisE molecular groups of endometrial cancer[J]. Gynecol Oncol, 2020, 157(1): 252-259.
[15] Xu D, Wang Y, Wu J, et al. ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway[J]. Cell Death Dis, 2021, 12(2): 162.
[16] Zhang H, Geng Y, Sun C, et al. Upregulation of ECT2 predicts adverse clinical outcomes and increases 5-fluorouracil resistance in gastric cancer patients[J]. J Oncol, 2021, 2021: 2102890. doi: 10.1155/2021/2102890.
[17] Wang H, Liu H, Li J, et al. Effect of ECT2 expression on the growth of triple-negative breast cancer cells with paclitaxel intervention[J]. Onco Targets Ther, 2020, 13: 12905-12918. doi: 10.2147/OTT.S275725.
[18] Yang Q, Yu B, Sun J. TTK, CDC25A, and ESPL1 as prognostic biomarkers for endometrial cancer[J]. Biomed Res Int, 2020, 2020: 4625123. doi: 10.1155/2020/4625123.
[19] Liu J, Wu Z, Sun R, et al. Using mRNAsi to identify prognostic-related genes in endometrial carcinoma based on WGCNA[J]. Life Sci, 2020, 258: 118231. doi: 10.1016/j.lfs.2020.118231.
[20] Li L, Xu DB, Zhao XL, et al. Combination analysis of Bub1 and Mad2 expression in endometrial cancer: act as a prognostic factor in endometrial cancer[J]. Arch Gynecol Obstet, 2013, 288(1): 155-165.
[21] Laine A, Nagelli SG, Farrington C, et al. CIP2A interacts with TopBP1 and drives basal-like breast cancer tumorigenesis[J]. Cancer Res, 2021, 81(16): 4319-4331.
[22] Cao C, Han P, Liu L, et al. Epithelial cell transforming factor ECT2 is an important regulator of DNA double-strand break repair and genome stability[J]. J Biol Chem, 2021, 297(3): 101036.
[23] Bai X, Yi M, Xia X, et al. Progression and prognostic value of ECT2 in non-small-cell lung cancer and its correlation with PCNA[J]. Cancer Manag Res, 2018, 10: 4039-4050. doi: 10.2147/CMAR.S170033.
[24] Sun BY, Wei QQ, Liu CX, et al. ECT2 promotes proliferation and metastasis of esophageal squamous cell carcinoma via the RhoA-ERK signaling pathway[J]. Eur Rev Med Pharmacol Sci, 2020, 24(15): 7991-8000.
[25] Tong N, He Z, Ma Y, et al. Tumor associated macrophages, as the dominant immune cells, are an indispensable target for immunologically cold tumor-glioma therapy?[J]. Front Cell Dev Biol, 2021, 9: 706286. doi: 10.3389/fcell.2021.706286.
[26] 许欣, 张颖, 陈超. 免疫细胞在子宫内膜癌中作用的研究进展[J]. 医学综述, 2021, 27(23): 4656-4660. XU Xin, ZHANG Ying, CHEN Chao. Research progress on the role of immune cells in endometrial cancer[J]. Medical Recapitulate, 2021, 27(23): 4656-4660.
[27] Crumley S, Kurnit K, Hudgens C, et al. Identification of a subset of microsatellite-stable endometrial carcinoma with high PD-L1 and CD8+ lymphocytes[J]. Mod Pathol, 2019, 32(3): 396-404.
[28] Xu D, Wang Y, Wu J, et al. ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway[J]. Cell Death Dis, 2021, 12(2): 162.
[29] Szczerba BM, Castro-Giner F, Vetter M, et al. Neutrophils escort circulating tumour cells to enable cell cycle progression[J]. Nature, 2019, 566(7745): 553-557.
[1] ZHANG Zhaoying, MA Chunhong. Immunomodulatory effects of bile acid in hepatointestinal diseases [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 30-36.
[2] QIAO Chong, WANG Tingting. Research progress of maternal-fetal immunomodulatory mechanism [J]. Journal of Shandong University (Health Sciences), 2021, 59(8): 24-31.
[3] WANG Yan, ZHANG Yuhui, HU Naibo, TENG Guangshuai, ZHOU Yuan, BAI Jie. Characteristics of bone marrow immune microenvironment in patients with acute myeloid leukemia based on single-cell RNA sequencing [J]. Journal of Shandong University (Health Sciences), 2021, 59(10): 32-40.
[4] LI Wenqing, YE Lan, JIANG Yuhua. CDK7 inhibitor THZ1 increases the radiosensitivity of human glioma cell line U251 [J]. Journal of Shandong University (Health Sciences), 2021, 59(1): 8-13.
[5] TIAN Baorui, ZHANG Yongchao, HAN Xiaoyang, TIAN Yingying, WANG Chuanxi. Prediction of the association between genes and glioblastoma based on databases [J]. Journal of Shandong University (Health Sciences), 2020, 58(6): 8-13.
[6] CUI Ximing, WANG Shuang, XU Shunjiang, ZHANG Rui, XIE Bing, CUI Dongsheng, ZHAO Zhansheng. Effect of resveratrol on the proliferation of human retinal capillary endothelial cells induced by high glucose and its possible mechanism [J]. Journal of Shandong University (Health Sciences), 2019, 57(3): 19-24.
[7] YAN Huili, WEI Muyun, YAN Lei, ZHAO Yueran. Effect of FK506 binding protein 52 on proliferation of human endometrial stromal cells [J]. Journal of Shandong University (Health Sciences), 2019, 57(2): 80-87.
[8] CHEN Yan, LIU Juan, CHEN Hanxiang, ZHANG Weifang, ZHAO Weiming. Effects of miR-17 on the senescence of human foreskin fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 55-59.
[9] LI Tao, WU Hongxi, ZHANG Yongchao, ZHENG Zhiming, ZHANG Zhen, TENG Liangzhu. The inhibitory effect of nitidine chloride on pituitary adenoma GH3 cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(10): 6-10.
[10] LI Mei-ying1, LI Ji-sheng1, YU Xue-jun1, SUN Li-mei1, WANG Ai-jun1, LIU Qi-ji2, WANG Xiu-wen1. Effects of bufalin on the proliferation and cell cycle of human pancreatic cancer CAPAN-2 cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(11): 37-41.
[11] TIAN Tian-tian1, LI Ji-sheng1, WANG Ya-wei1, MA Dao-xin2, WANG Xiu-wen1. Genistein exerts antitumor effects in small cell lung cancer H446 cells via suppressing the activity of FoxM1 pathway [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(06): 44-48.
[12] ZHU Zu-an1, FEI Su-juan1, LIU Lei2, ZHANG Qiu-yue1, SUN Min1, LIU Ying2. Effect of SKI-II on SGC7901 cell cycle by inhibiting the Sphk1 expression [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(4): 70-74.
[13] ZENG Zhao-qing1，2, DU Wen-jun2, SHI Zhao-zhang2, XU Wei3, LIU Qian-wen3, CHEN Shi-jun4. Effect of the interlukin-17 on proliferation and cell cycle of the hepatic stellate cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(4): 21-24.
[14] WANG Rui-jie1, XU Hong-zhi1, HUANG Min3, MA Chun-yan2, SUI Xiao-hui1, LIU Xin1, ZHANG Bing-chang3, LI Yuan-tang3. Cell cycle distributions and cell proliferation-related protein expression in  myelodysplastic syndromes, aplastic anemia, and acute leukemia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(2): 97-101.
[15] CHEN Shi-min1，2, XIN Jia-xuan1, XU Chun-xiao1, LIU Bin1, SUN Xiao-ming2, HU Cheng-jin2, LIU Xian-xi1. Effects of UbcH10 expression on proliferation of colorectal cancer cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(1): 35-38.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] MA Qingyuan, PU Peidong, HAN Fei, WANG Chao, ZHU Zhoujun, WANG Weishan, SHI Chenhui. Effect of miR-27b-3p regulating SMAD1 on osteosarcoma cell proliferation, migration and invasion[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 32 -37 .
[2] SUO Dongyang, SHEN Fei, GUO Hao, LIU Lichang, YANG Huimin, YANG Xiangdong. Expression and mechanism of Tim-3 in animal model of drug-induced acute kidney injury[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 1 -6 .
[3] LONG Tingting, XIE Ming, ZHOU Lu, ZHU Junde. Effect of Noggin protein on learning and memory abilities and the dentate gyrus structure after cerebral ischemia reperfusion injury in mice[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 15 -23 .
[4] LI Ning, LI Juan, XIE Yan, LI Peilong, WANG Yunshan, DU Lutao, WANG Chuanxin. Expression of LncRNA AL109955.1 in 80 cases of colorectal cancer and its effect on cell proliferation, migration and invasion[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 38 -46 .
[5] DING Xiangyun, YU Qingmei, ZHANG Wenfang, ZHUANG Yuan, HAO Jing. Correlation of the expression of insulin-like growth factor II in granulosa cells and ovulation induction outcomes of 84 patients with polycystic ovary syndrome[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 60 -66 .
[6] XU Yuxiang, LIU Yudong, ZHANG Peng, DUAN Ruisheng. A retrospective analysis of risk factors of cerebral microbleeds in 101 patients with cerebral small vessel disease[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 67 -71 .
[7] SHI Shuang, LI Juan, MI Qi, WANG Yunshan, DU Lutao, WANG Chuanxin. Construction and application of a miRNAs prognostic risk assessment model of gastric cancer[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 47 -52 .
[8] ZHANG Baowen, LEI Xiangli, LI Jinna, LUO Xiangjun, ZOU Rong. miR-21-5p targeted TIMP3 to inhibit proliferation and extracellular matrix accumulation of mesangial cells in Type II diabetic nephropathy mice[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 7 -14 .
[9] FU Jieqi, ZHANG Man, ZHANG Xiaolu, LI Hui, CHEN Hong. Molecular mechanism of Toll-like receptor 4 in the aggravation of blood lipid accumulation by inhibiting the peroxisome proliferator-activate receptor γ[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 24 -31 .
[10] GUO Zhihua, ZHAO Daqing, XING Yuan, WANG Wei, LIANG Leping, YANG Jing, ZHAO Qianqian. Single-stage end-to-end anastomosis in the management of severe cervical tracheal stenosis[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 72 -76 .
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd